1. Ke-Bin Huang, Feng-Yang Wang, Xiao-Ming Tang, Hai-Wen Feng, Zhen-Feng Chen*, Yan-Cheng Liu, You-Nian Liu and Hong Liang*. Organometallic gold(III) complexes similar to tetrahydroisoquinoline(THIQ) induce ER-stress-mediated apoptosis andpro-death autophagyin A549 cancer cells. J. Med. Chem., 2018, 61, 3478-3490.
2. Zhen-FengChen,* Qi-Pin Qin, Jiao-Lan Qin, Yan-Cheng Liu, Ke-Bin Huang, Yu-Lan Li,Ting Meng, Guo-Hai Zhang,Yan Peng, Xu-Jian Luo, Hong Liang*. Stabilization of G-quadruplex DNA, inhibition of telomerase activity, and tumor cell apoptosis by organoplatinum(II) complexes with oxoisoaporphine. J. Med. Chem., 2015, 58, 2159-2179.
3. Zhen-Feng Chen,* Qi-Pin Qin, Jiao-Lan Qin, Jie Zhou, Yu-Lan Li, Nan Li, Yan-Cheng Liu, Hong Liang*. Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): invitro and in vivo anticancer activity by stabilization of G-quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis. J. Med. Chem., 2015, 58, 4771-4789.
4. Yan-Cheng Liu, Zhen-Feng Chen*, Xiao-Yan Song, Yan Peng, Qi-Pin Qin, Hong Liang*. Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dibromo-8-quinolinolato- lanthanides. Eur. J. Med. Chem., 2013, 59, 168-175.
5. Zhen-Feng Chen*, Yun-Qiong Gu, Xiao-Yan Song, Yan-Cheng Liu, Yan Peng, Hong Liang*. Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dichloro-8- quinolinolato-lanthanides. Eur. J. Med. Chem., 2013, 59, 194-202.
6. Zhen-Feng Chen*, Yan Peng, Yun-Qiong Gu, Yan-Cheng Liu, Mei Liu, Ke-Bin Huang, Kun Hu and Hong Liang*. High antitumor activity of 5,7-dihalo-8- quinolinolato tin(IV) complexes. Eur. J. Med. Chem., 2013, 62,51-58.
7. Ke-Bin Huang, Zhen-Feng Chen*, Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang， Guo-Hai Zhang, Hong Liang*. Platinum(II) complexes with mono-aminopho- sphonate ester targeting group that induce apoptosis through G1 cell-cycle arrest: Synthesis, crystal structure and antitumour activity. Eur. J. Med. Chem., 2013, 63, 76-84.
8. Ke-Bin Huang, Zhen-Feng Chen,* Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang, Xiao-Li Xie, and Hong Liang*. Platinum(II) complexes containing aminophosphonate esters: synthsis, characterization, cytotoxicity and action mechanism. Eur. J. Med. Chem., 2013, 64, 554-561.
9. Zhen-Feng Chen,* Jian-Hua Wei, Yan-Cheng Liu, Mei Liu, Yun-Qiong Gu, Ke-Bin Huang, Meng Wang, Hong Liang*. High antitumor activity of 5,7-dihalo-8-quinolinolato cerium complexes. Eur. J. Med. Chem., 2013, 68, 454-462.
10. Yan-Cheng Liu, Jian-Hua Wei, Zhen-Feng Chen*, Mei Liu, Yun-Qiong Gu, Ke-Bin Huang, Zhu-Quan Li and Hong Liang*. The antitumor activity of zinc(II) and copper(II) complexes with 5,7-dihalo-substituted-8-quinolinoline. Eur. J. Med. Chem., 2013, 69,554-563.
11. Ke-Bin Huang, Zhen-Feng Chen*, Yan-Cheng Liu, Meng Wang, Jian-Hua Wei, Xiao-Li Xie, Jian-Lian Zhang, Kun Hu, Hong Liang*. Copper(II/I) complexes of 5-pyridin-2-yl-[1,3] dioxolo[4,5-g]isoquinoline: synthesis, crystal structure, antitumor activity and DNA interaction. Eur. J. Med. Chem., 2013, 70, 640-648.
12. Qi-Pin Qin, Zhen-Feng Chen*, Wen-Ying Shen, Yan-Hua Jiang, Dong Cao, Yu-Lan Li, Qing-Min Xu, Yan-Cheng Liu, Ke-Bin Huang, Hong Liang*. Synthesis of a platinum(II) complex with 2-(4-methoxy-phenyl)imidazo [4,5-f]-[1,10] phenanthrolin and study of its antitumor activity. Eur. J. Med. Chem., 2015, 89, 77-87.
13. Qi-Pin Qin, Zhen-Feng Chen*, Jiao-Lan Qin, Xiao-Ju He, Yu-Lan Li, Yan-Cheng Liu, Ke-Bin Huang and Hong Liang*. Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: synthesis, characterization, cytotoxicity, cell cycle and apoptosis. Eur. J. Med. Chem., 2015, 92, 302-313.
14. Qi-Pin Qin, Jiao-Lan Qin, Ting Meng, Wan-Hua Lin, Chuan-Hui Zhang, Zu-Zhuang Wei, Jia-Nian Chen, Yan-Cheng Liu, Hong Liang, Zhen-Feng Chen*. High in vivo antitumor activity of cobalt oxoisoaporphine complexes by targeting G-quadruplex DNA, telomerase and disrupting mitochondrial functions. Eur. J. Med. Chem., 2016, 124, 380−392.
15. Yan-Cheng Liu, Jian-Hua Wei, Zhen-Feng Chen*, Mei Liu, Yun-Qiong Gu, Ke-Bin Huang, Zhu-Quan Li and Hong Liang*. The antitumor activity of zinc(II) and copper(II) complexes with 5,7-dihalo-substituted-8-quinolinoline. Eur. J. Med. Chem., 2013, 69,554-563.
16. Zu-Zhuang Wei(#), Qi-Pin Qin(#), Ting Meng, Cai-Xing Deng, Hong Liang, Zhen-Feng Chen*. 5-Bromo-oxoisoaporphine platinum(II) complexes exhibit tumor cell cytotoxcicity via inhibition of telomerase activity and disruption of c-myc G-quadruplex DNA and mitochondrial functions. Eur. J. Med. Chem., 2018, 145, 360-369.
17. Wen-Bin Kuang, Ri-Zhen Huang, Jiao-Lan Qin, Xing Lu, Qi-Pin Qin, Bi-Qun Zou, Zhen-Feng Chen,**, Hong Liang,***, Ye Zhang*. Design, synthesis and pharmacological evaluation of new 3-(1Hbenzimidazol-2-yl)quinolin-2(1H)-one derivatives as potential antitumor agents. Eur. J. Med. Chem., 2018, 157, 139-150.
18. Taj-Malook Khan, Noor Shad Gul, Xing Lu, Jian-Hua Wei, Yan-Cheng Liu, Hongbin Sun*, Hong Liang***, Chris Orvig, Zhen-Feng Chen**. In vitro and in vivo anti-tumor activity of two gold(III) complexes with isoquinoline derivatives as ligands. Eur. J. Med. Chem., 2019, 163, 333-342.
19. Bao-Li Fei*, Shuangyan Tu, Zuzhuang Wei, Pingping Wang, Chunhua Qiao ***, Zhen-Feng Chen**. Optically pure chiral copper(II) complexes of rosin derivative as attractive anticancer agents with potential anti-metastatic and anti-angiogenic activities.Eur. J. Med. Chem., 2019, 176, 175-186.
20. Xing Lu, Yan-Cheng Liu, Chris Orvig, Hong Liang **, Zhen-Feng Chen*. Discovery of b-carboline copper(II) complexes as Mcl-1 inhibitor and in vitro and in vivo activity in cancer models. Eur. J. Med. Chem., 2019, 181, 111567.
21. Zhen-Feng Chen*, Chris Orvig and Hong Liang*. Multi-target metal-based anticancer agents. Current Topics in Medicinal Chemistry, 2017,17, 1331-1345.
22. Zhen-Feng Chen*, Yan-Cheng Liu, Ke-Bin Huang and Hong Liang*. Alkaloid-metal based anticancer agents. Current Topics in Medicinal Chemistry, 2013, 13, 2104-2115.
23. Zhen-Feng Chen*, Yan-Fang Shi, Yan-Cheng Liu, Xue Hong, Bo Geng, Yan Peng, Hong Liang*, TCM active ingredient oxoglaucine metal complexes: Crystal structure, cytotoxicity and interaction with DNA. Inorganic Chemistry, 2012, 51, 1998-2009.
24. Bao-Li Fei*, Shuangyan Tu, Zuzhuang Wei, Pingping Wang, Jian-Ying Long, Chunhua Qiao* and Zhen-Feng Chen*. Biological evaluation of optically pure chiral binuclear copper(II) complexes based on rosin derivative as highly potential anticancer agents.Dalton Trans., 2019, DOI: 10.1039/C9DT01942A.
25. Taj-Malook Khan, Noor Shad Gul, Xing Lu, Rajesh Kumar, Muhammad Iqbal Choudhary,b Hong Liang* and Zhen-Feng Chen*. Rhodium(III) complexes with isoquinoline derivatives as potential anticancer agents: in vitro and in vivo activity studies. Dalton Trans., 2019, 48,11469-11479.
26. Qi-Pin Qin, Jiao-Lan Qin, Ming Chen, Yu-Lan Li, Ting Meng, Jie Zhou, Hong Liang*, Zhen-Feng Chen*. Chiral platinum(II)-4-(2,3-Dihydroxypropyl)- formamide oxoaporphine (FOA) complexes promote tumor cells apoptosis by directly targeting G-quadruplex DNA in vitro and in vivo. Oncotarget, 2017, 8, 61982-61997.
27. Jiao-Lan Qin†, Ting Meng†, Zhen-Feng Chen*, Xiao-Li Xie, Qi-Pin Qin, Xiao-Ju He, Ke-Bin Huang, Hong Liang*. Facile total synthesis of lysicamine and the anticancer activities of the RuII, RhIII, MnII and ZnII complexes of lysicamine. Oncotarget, 2017, 8, 59359-59375.
28. Jiao-Lan Qin(#), Wen-Ying Shen(#), Zhen-Feng Chen*, Li-Fang Zhao, Qi-Pin Qin, Yan-Cheng Yu & Hong Liang*. Oxoaporphine metal complexes (CoII, NiII, ZnII) with high antitumor activity by inducing mitochondria-mediated apoptosis and S-phase arrest in HepG2. Scientific Reports, 2017, 7:46056.
29. Qi-Pin Qin(#), Jiao-Lan Qin(#), Ting Meng, Gui-Ai Yang, Zu-Zhuang Wei, Yan-Cheng Liu, Hong Liang* & Zhen-Feng Chen*.Preparation of 6/8/11-amino/chloro-oxoisoaporphine and group-10 metal complexes and evaluation of their in vitro and in vivo antitumor activity. Scientific Reports, 2016, 6: 37644.
30. Guohai Zhang, Yunfeng An, Xing Lu, Hui Zhong, Yanhong Zhu, Yiming Wu, Feng’e, Ma, Jingmei Yang, Yancheng Liu, Zuping Zhou, Yan Peng*, Zhenfeng Chen*. A novel naphthalimide compound restores p53 function in non–small–cell lung cancer by reorganizing the Bak–Bcl-xl complex and triggering transcriptional regulation. J. Biol. Chem., 2016, 291, 4211-4225.
31. Guo-Hai Zhang#, Le-Jing Cai#, Yan-Fei Wang, Yuan-Hua Zhou, Yun-Feng An, Yan-Cheng Liu, Yan Peng*, Zhen-Feng Chen*, Hong Liang*. Novel compound PS-101 exhibits selective inhibition in non–small-cell lung cancer cell by blocking the EGFR-driven antiapoptotic pathway. Biochemical Pharmacology, 2013, 86, 1721-1730.
32. Zu-Yu Mo, Toreshettahally R. Swaroop, Wei Tong, Yu-Zhen Zhang,Hai-Tao Tang,* Ying-Ming Pan,* Hong-Bin Sun and Zhen-Feng Chen*. Electrochemical sulfonylation of thiols with sulfonyl hydrazides: a metal- and oxidant-free protocol for the synthesis of thiosulfonates. Green Chemistry, 2018, 20(19), 4428-4432.32.
33. Pei Liu, Jin-ling Liu, Heng-shan Wang,Ying-ming Pan*, Hong Liang, and Zhen-Feng Chen*. Copper-mediated crossing-coupling/cyclization/oxidation: One-pot to construct polysubstitutedpyrroles. Chem. Commun. 2014, 50, 4795-4798.
34. Pei Liu, Heng-shan Wang, Ying-ming Pan,* Wei-long Dai, Hong Liang and Zhen-Feng Chen*. The first palladium-catalyzed 1,4-addition of terminal alkenes to acrylate esters. Chem. Commoun., 2013, 49, 5295-5297.
35. Xu Wang, Shen-yan Li, Ying-ming Pan*, Heng-shan Wang, Hong Liang, Zhen-Feng Chen*, and Xiao-huan Qin. Samarium(III)-catalyzed C(sp3)–H bond activation: Synthesis of indolizines via C–C and C–N coupling between 2-alkylazaarenes and propargylic alcohols. Org. Lett., 2014, 16, 580-583.