Associate Prof. Ke-Bin Huang, Ph.D.,
Dr. K. –B. Huang received his Ph.D in 2013 in Nankai University, China. He is the supervisor for Master Degree Program of Medicinal Chemistry. He is mainly engaged novel metal-based drug improved tumor-immunotherapy；novel metal-based drug regulated key target of tumor.
Education
2010.09-2013.06 NanKai University, Doctor
2007.09-2010.06 Guangxi Normal University, Master
2003.09-2007.06 Guangxi Normal University, Bachelor
Professional Experience
2018-2020 Visiting Scholar, Molecular and Cellular Oncology, M. D. Anderson Cancer Center, Houston, USA.
2016-Current Associate Professor, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China
2013-2015 Lecturer, School of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, China
Representative Publications
1. Ke-Bin Huang,Feng-Yang Wang,Xiao-Ming Tang,Hai-Wen Feng,Zhen-Feng Chen, Yan-Cheng Liu,You-Nian Liu, and Hong Liang. Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells, Journal of Medicinal Chemistry, 2018, 61, 3478 – 3490.
2. Feng-Yang Wang, Ke-Bin Huang⁎, Hai-Wen Feng, Zhen-Feng Chen, You-Nian Liu, Hong Liang.New Platinum(II) agent induces bimodal death of apoptosis and autophagy against A549 cancer cell,Free Radical Biology and Medicine, 2018, 129, 418–429.
3. Feng-Yang Wang, Xiao-Ming Tang, Xia Wang, Ke-Bin Huang⁎, Hai-Wen Feng, Zhen-Feng Chen, You-Nian Liu, Hong Liang,Mitochondria-targeted platinum(II) complexes induce apoptosis-dependent autophagic cell death mediated by ER-stress in A549 cancer cells, European Journal of Medicinal Chemistry, 2018, 155, 639 ~ 650.
4. Feng-Yang Wang, Qian-Yu Xi, Ke-Bin Huang*, Xiao-Ming Tang, Zhen-Feng Chen, Yan-Cheng Liu, Hong Liang⁎, Crystal structure, cytotoxicity and action mechanism of Zn (II)/Mn(II) complexes with isoquinoline ligands, Journal of Inorganic Biochemistry, 2017, 169,23 ~ 31.
5. Zhong-Yuan Mao, Xiao-Yun Liao, Heng-Shan Wang, Chun-Gu Wang, Ke-Bin Huang* and Ying-Ming Pan，Acid-catalyzed tandem reaction for the synthesis of pyridine derivatives via C]C/C(sp3)–N bond cleavage of enones and primary amines，RSC Advances,2017, 7, 13123–13129.
6. Hai-Rong Zhang, Ke-Bin Huang,* Zhen-Feng Chen,Yan-Cheng Liu, You-Nian Liu, Ting Meng, Qi-Pin Qin, Bi-Qun Zou and Hong Liang, Cobalt(II) 8-hydroxyquinoline complexes: structure, cytotoxicity, and action mechanism, MedChemComm,2016, 7, 806-812.
7. Ke-Bin Huang, Hui-Yan Mo, Zhen-Feng Chen, Jian-Hua Wei, Yan-Cheng Liu, Hong Liang. Isoquinoline derivatives Zn(II)/Ni(II) complexes: Crystal structures, cytotoxicity, and their action mechanism. European Journal of Medicinal Chemistry, 2015, 100, 68 ~ 76.
8. Ke-Bin Huang, Zhen-Feng Chen, Yan-Cheng Liu, Xiao-Li Xie and Hong Liang, Dihydroisoquinoline copper(II) complexes: crystal structures, cytotoxicity, and action mechanism, RSC Advances, 2015, 5, 81313 ~ 81323.
9. Ke-Bin Huang, Zhen-Feng Chen, Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang, Guo-Hai Zhang, Hong Liang. Platinum(II) complexes with mono-aminophosphonate ester targeting group that induce apoptosis through G1 cell-cycle arrest: Synthesis, crystal structure and antitumour activity. European Journal of Medicinal Chemistry, 2013, 63, 76 ~ 84.
10. Ke-Bin Huang, Zhen-Feng Chen, Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang, Xiao-Li Xie, Hong Liang. Platinum(II) complexes containing aminophosphoate esters: synthsis, characterization, cytotoxicity and action mechanism. European Journal of Medicinal Chemistry, 2013, 64, 554 ~ 561.
11. Ke-Bin Huang, Zhen-Feng Chen, Yan-Cheng Liu, Meng Wang, Jian-Hua Wei, Xiao-Li Xie, Jian-Lian Zhang, Kun Hu, Hong Liang. Copper(II/I) complexes of 5-pyridin-2-yl-[1,3]dioxolo[4,5-g]isoquinoline Synthesis, crystal structure, antitumor activity and DNA interaction. European Journal of Medicinal Chemistry, 2013, 70, 640 ~ 648.