基本情况介绍

湖南大学获分析化学学士学位，四川大学获化学工程博士学位，美国杰克逊州立大学研究助理，俄罗斯莫斯科大学化学系合作研究（2013-2015）。广西师范大学化学与药学学院前院长，二级教授，博士生导师。中国化学会有机分析专业委员会委员，国家自然科学基金委员会化学部专家评审组成员，广西自然科学基金专家委员会委员，广西化学化工学会常务理事，分析测试专业委员会主任。已主持各类科研课题20多项。其中国家自然科学基金项目8项，省部级科研项目10多项。在国内外重要学术期刊上发表学术论文380余篇,其中SCI源刊论文280多篇。获国家授权发明专利7项。参写中英文专著5部。负责制定国家标准2项。科研成果获广西自然科学奖一等奖2项，二等奖1项，三等奖1项。广西科技进步奖二等奖1项，三等奖1项。

教育背景

2003/09-2006/06 四川大学，化学工程学院，博士

1995/06-1997/12湖南大学，化学化工学院，研究生班

1978/03-1982/01湖南大学，化学化工学院，学士

工作经历

2001/09-现在广西师范大学化学与药学学院，教授/博士生导师

1999/08-2001/08美国杰克逊州立大学，助理研究员

1998/01-1999/07广西师范大学化学，化学化工学院，副教授

1992/03-1997/12 沈阳化工大学，应用化学学院，副教授

1982/02-1992/01原机械电子工业部，机械科学研究院铸造研究所，工程师

荣誉及人才称号

（1）广西八桂学者（2016）

（2）广西优秀专家（2010）

（3）广西八桂名师（2010）

（4）广西先进工作者（2010）

学术论文Publications（2018-present）

1. Design of a New Near-Infrared Ratiometric Fluorescent Nanoprobe for Real-Time Imaging of Superoxide Anions and Hydroxyl Radicals in Live Cells and in Situ Tracing of the Inflammation Process in Vivo. Rongjun Liu, Liangliang Zhang,* Yunyun Chen, Zirong Huang, Yong Huang, Shulin Zhao* Anal. Chem. 2018, 90, 4452−4460.

2. Capsicum-Derived Biomass Quantum Dots Coupled with Alizarin Red S as an Inner-Filter-Mediated Illuminant Nanosystem for Imaging of Intracellular Calcium Ions. Dongxia Chen, Jingjin Zhao, Liangliang Zhang,* Rongjun Liu, Yong Huang, Chuanqing Lan, Shulin Zhao* Anal. Chem. 2018, 90, 13059−13064.

3. Boric-Acid-Functionalized Covalent Organic Framework for Specific Enrichment and Direct Detection of cis-Diol-Containing Compounds by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. Kun Hu, Yuanxia Lv, Fanggui Ye,* Tao Chen, Shulin Zhao* Anal. Chem. 2019, 91, 6353−6362.

4. A ratiometric multicolor fluorescence biosensor for visual detection of alkaline phosphatase activity via a smartphone. Li Hou, Yuxin Qin, Jinying Li, Siyuan Qin, Yuanlin Huang, Tianran Lin,∗Liangqia Guo, Fanggui Ye, Shulin Zhao. Biosensors and Bioelectronics. 2019,143, 111605.

5. Single-excitation, dual-emission biomass quantum dots: preparation and application for ratiometric fluorescence imaging of coenzyme A in living cells. Yong Cui, Rongjun Liu, Fanggui Ye, Shulin Zhao*. Nanoscale, 2019, 11, 9270–9275.

6. Dual functionalized natural biomass carbon dots from lychee exocarp for cancer cell targetable near-infrared fluorescence imaging and photodynamic therapy. Mingyue Xue, Jingjin Zhao, Zhihua Zhan, Shulin Zhao,* Chuanqing Lan, Fanggui Ye and Hong Liang.* Nanoscale, 2018, 10, 18124–18130.

7. Real-time tracing the changes in the intracellular pH value during apoptosis by near-infrared ratiometric fluorescence imaging, Liyun Lin, Jingjin Zhao,* Liangliang Zhang, Yong Huang, Fanggui Ye , Shulin Zhao.* Chem.Commun., 2018, 54, 9071—9074.

8. One-pot synthesis of a metal–organic framework-based drug carrier for intelligent glucose-responsive insulin delivery. Yan Duan, Fanggui Ye,* Yuanlin Huang, Yuemei Qin, Caimei He, Shulin Zhao.* Chem. Commun., 2018, 54, 5377—5380.

9. A gold nanoparticle-based four-color proximity immunoassay for one-step, multiplexed detection, of protein biomarkers using ribonuclease H signal, amplification. Jiayao Xu, Ming Shi, Wenting Chen, Yong Huang,* Lina Fang, Lifang Yao, Shulin Zhao,* Zhen-Feng Chen, Hong Liang*.Chem.Commun., 2018, 54, 2719—2722.

10. A label-free fluorescence assay for hydrogen peroxide and glucose based on the bifunctional MIL-53(Fe) nanozyme. Tianran Lin, Yuemei Qin, Yuanlin Huang, Ruitao Yang, Li Hou, Fanggui Ye,* Shulin Zhao. Chem. Commun., 2018, 54, 1762—1765.

11. Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo. Zhengmin Yang, Wenxiu Li, Hua Chen, Qingyuan Mo, Jun Li,* Shulin Zhao, Cheng Hou, Jiangke Qin,* Guifa Su. Chem. Commun., 2019, 55, 2477—2480.

12. A peptide-based four-color fluorescent polydopamine nanoprobe for multiplexed sensing and imaging of proteases in living cells. Jiayao Xu, Lina Fang, Ming Shi, Yong Huang,* Lifang Yao, Shulin Zhao,* Liangliang Zhang, Hong Liang*. Chem. Commun., 2019, 55, 1651—1654.

13. A red emitting fluorescent probe for sensitively monitoring hydrogen polysulfides in living cells and zebrafish. Wenxiu Lia, Simin Zhoua, Liangliang Zhang,* Zhengmin Yang, Hua Chen, Wenqiang Chen,* Jiangke Qin, Xingcan Shen, Shulin Zhao.  Sensors and Actuators B2019, 284, 30-35.

14. Polydopamine nanoparticle-based multicolor proximity immunoassays for ultrasensitive, multiplexed analysis of proteins using isothermal quadratic amplification. Lifang Yao, Jiayao Xu, Ming Shi, Yong Huang,* Lina Fang, Shulin Zhao,* Zhen-Feng Chen, Hong Liang*. Sensors and Actuators B2019, 282, 626-635.

15. A bifunctional metal organic framework of type Fe(III)-BTC for cascade (enzymatic and enzyme-mimicking) colorimetric determination of glucose. Zhenghong Zhao, Junhong Pang, Wenren Liu, Tianran Lin, Fanggui Ye,* Shulin Zhao.Microchimica Acta 2019, 186, 295.

16. Fluorometric determination of microRNA-122 by using ExoIII-aided recycling amplification and polythymine induced formation of copper nanoparticles. Yafang Tang, Mingxiu Liu, Zilin Zhao, Qing Li, Xuehua Liang, Jianniao Tian,* Shulin Zhao. Microchimica Acta 2019, 186, 133.

17. An aptamer-based four-color fluorometic method for simultaneous determination and imaging of alpha-fetoprotein, vascular endothelial growth factor-165, carcinoembryonic antigen and human epidermal growth factor receptor 2 in living cells. Jiayao Xu, Wenting Chen, Ming Shi, Yong Huang,* Lina Fang, Shulin Zhao,* Lifang Yao, Hong Liang*. Microchimica Acta 2019, 186, 204.

18. In-situ growth of cobalt oxyhydroxide on graphitic-phase C₃N₄ nanosheets for fluorescence turn-on detection and imaging of ascorbic acid in living cells. Yuanxia Lv, Caiyan Jiang, Kun Hu,* Yong Huang, Yunfeng He, Xiaoying Shen, Shulin Zhao*. Microchimica Acta 2019, 186, 360.

19. Fluorescence polarization gene assay for HIV-DNA based on the use of dendrite-modified gold nanoparticles acting as signal amplifiers, Shuping Liang, Guicheng He, Jianniao Tian* Yanchun Zhao, Shulin Zhao.Microchim Acta 2018, 185, 119.

20. Ultrasensitive fluorescent detection of nucleic acids based on labelfree enzymatic-assisted cascade signal amplification, Yingfeng Qin, Suqi Liao, Yufeng Huang, Jingjin Zhao,* Shulin Zhao.Analytica Chimica Acta 2018, 1039, 91-97.

21. Self-assembled nanomaterials for synergistic antitumour therapy, Chuanqing Lan, Shulin Zhao.* J. Mater. Chem. B2018, 6, 6685-6704.

22. Quantification of glutathione in single cells from rat liver by microchip electrophoresis with chemiluminescence detection. Ming Shi, Yong Huang, Jingjin Zhao, Shuting Li, Rongjun Liu, Shulin Zhao*.Talanta 2018, 179, 466–471.

23. A novel multiplex signal amplification strategy based on microchip electrophoresis platform for the improved separation and detection of microRNAs. Kaiji Wei, Jingjin Zhao, Yingfeng Qin, Shuting Li, Yong Huang, Shulin Zhao*. Talanta 2018, 189, 437–441.

24. A novel microchip electrophoresis laser induced fluorescence detection method for the assay of T4 polynucleotide kinase activity and inhibitors. Yan Zhang, Jingjin Zhao,∗ Shenyu Chen, Shuting Li, Shulin Zhao∗. Talanta 2019, 202, 317-322.

25. A T7 exonuclease assisted dual-cycle signal amplification assay of miRNA using nanospheres-enhanced fluorescence polarization. Xiaoting Lia, Nian Huang, Liangliang Zhang, Jingjin Zhao,∗Shulin Zhao. Talanta2019, 202, 297-302.

26. Facile synthesis of magnetic carbon nanotubes derived from ZIF-67 and application to magnetic solid-phase extraction of profens from human serum. Wenqian Wu, Feng Lin, Xiaohan Yang, Bin Wang, Xin Lu,^∗Qiuxia Chen, Fanggui Ye,^∗Shulin Zhao. Talanta2019, 207, 120284.

27. An ultrasensitive microchip electrophoresis assay based on separation- assisted double cycling signal amplification strategy for microRNA detection in cell lysate. Kaiji Wei, Jingjin Zhao,* Xiaoshu Luo, Senghui Qiu, Fuyun He, Shuting Li, Shulin Zhao*. Analyst 2018, 143, 1468–1474.

28. A fluorescent aptasensor based on single oligonucleotide-mediated isothermal quadratic amplification and graphene oxide fluorescence quenching for ultrasensitive protein detection.Jiayao Xu, Ming Shi, Huakui Huang, Kun Hu,* Wenting Chen,Yong Huang,* Shulin Zhao. Analyst 2018, 143, 3918–3925.

29. Magnetic Cu/Fe₃O₄@FeOOH with intrinsic HRP-like activity at nearly neutral pH for one-step biosensing. Yuanlin Huang, Guangzhao Liang, Tianran Lin,* Li Hou, Fanggui Ye,* Shulin Zhao. Analytical and Bioanalytical Chemistry, 2019, 411, 3801–3810.

30. Colorimetric detection of thioglycolic acid based on the enhanced Fe³⁺ ions Fenton reaction. Yuanlin Huang, Tianran Lin.* Li Hou, Fanggui Ye,* Shulin Zhao. Microchemical Journal 2019, 144, 190-194.

31. Biomass-based quantum dots co-doped with sulfur and nitrogen for highly sensitive detection of thrombin and its inhibitor. Yuefang Hu, Jingjin Zhao, Xuefeng Li, Shulin Zhao*. New J. Chem.,2019, 43, 11510-11516.

32. Rapid and label-free fluorescence bioassay for microRNA based on exonuclease III-assisted cycle amplification. Ming Xiu Liu, Shuping Liang, Yafang Tang, Jianniao Tian,* Yanchun Zhao,* Shulin Zhao. RSC Advances 2018, 8, 15967–15972.

33. Colorimetric detection of blood glucose based on GOx@ZIF-8 @Fepolydopamine cascade reaction. Zhenghong Zhao, Tianran Lin,* Wenren Liu, Li Hou, Fanggui Ye,* Shulin Zhao. Spectrochimica Acta Part A 2019, 219, 240–247.

34. A G-quadruplex/hemin DNAzyme-based microchip electrophoresis chemiluminescence assay for highly sensitive detection of biotin in flour. Jian Li, Shuting Li, Jingjin Zhao, Yong Huang, Shulin Zhao∗. Electrophoresis2019, 40, 2157–2164.

35. A simple and rapid dual-cycle amplification strategy for microRNA based on graphene oxide and exonuclease III-assisted fluorescence recovery,Yafang Tang, Mingxiu Liu, Lingcao Xu, Jianniao Tian, * Xiulin Yang,* Yanchun Zhao, Shulin Zhao. Anal. Methods 2018, 10, 3777–3782.

36. A novel chemiluminescence signal amplification strategy based on a capillary electrophoresis platform for highly sensitive competitive immunoassay of biomolecules, Min Shi, Jingjin Zhao, Shuting Li,* Jianniao Tian, Shulin Zhao.* Anal. Methods 2018, 10, 5499–5506.

37. Aptamer and IR820 Dual-Functionalized Carbon Dots for Targeted Cancer Therapy against Hypoxic Tumors Based on an 808 nm Laser-Triggered Three-Pathway Strategy, Rongjun Liu, Liangliang Zhang,* Jingjin Zhao, Zhihui Luo, Yong Huang, Shulin Zhao*.Adv. Therap. 2018, 1, 1800041.

38. A Distinctive Spinach-Based Carbon Nanomaterial with Chlorophyll-Rich and Near-Infrared Emission for Simultaneous In Vivo Biothiol Imaging and Dual-Enhanced Photodynamic Therapy of Tumor.Rongjun Liu, Liangliang Zhang,* Jingjin Zhao, Cheng Hou, Yong Huang, Zirong Huang, Shulin Zhao.* Adv. Therap.2019, 2, 1900011.