合成药物化学方向

1.    Yi-Yu Lin, Yan Lu, Chun-Yun Li, Xue-Fei Ma, Miao-Qing Shao, Yu-Hao Gao,Yu-Qing Zhang, Hai-Ning Jiang, Yan Liu, Yang Yang, Li-Dong Huang, Peng Cao, Heng-ShanWang*, Jin Wang*, Ye Yu*. Finely ordered intracellulardomain harbors anallosteric site to modulatephysiopathological function of P2X3 receptors. NatureCommunications, 2024, 15, 7652.

2.    Meng Wang, Guoxiu Cao, Junjie Zhou, Jinyuan Cai, Xianjie Ma, Zhikun Liu*,Xiaochao Huang*, Hengshan Wang*. Ligustrazine-Derived Chalcones-ModifiedPlatinum(IV) Complexes Intervene in Cisplatin Resistance in Pancreatic Cancerthrough Ferroptosis and Apoptosis. J.Med. Chem., 2023, 66(19):13587-13606.

3.    Liu Zhikun, Wang Meng, Huang Rizhen, Hu Tianhui, Jing Yi, Huang Xiaochao,Hu Weiwei, Cao Guoxiu*, Wang Hengshan*. Novel Indole-Chalcone Derivative-Ligated Platinum(IV) Prodrugs Attenuate CisplatinResistance in Lung Cancer through ROS/ER Stress and Mitochondrial Dysfunction. J. Med. Chem., 2023, 66(7): 4868-4887.

4.    Meng Wang, Guimei Li, Guiyang Jiang, Jinyuan Cai, Zhikun Liu, RizhenHuang*, Xiaochao Huang*, Hengshan Wang*. Novel NF-κBInhibitor-Conjugated Pt(IV) Prodrug to Enable Cancer Therapy through ROS/ERStress and Mitochondrial Dysfunction and Overcome Multidrug Resistance. J. Med. Chem., 2024, 67, 8, 6218–6237.

5.    RizhenHuang, Xiaoteng Jing, Xiaochao Huang, Yingming Pan, Yilin Fang, Guibin Liang,Zhixin Liao, Hengshan Wang*,Zhenfeng Chen*, and Ye Zhang*. Bifunctional Naphthoquinone Aromatic Amide-OximeDerivatives Exert Combined Immunotherapeutic and Antitumor Effects throughSimultaneous Targeting of Indoleamine-2,3-Dioxygenase and Signal Transducer andActivator of Transcription 3. J. Med.Chem., 2020, 63(4):1544-1563.

6.    X iang-Jun Peng, Hai-Ping He , Qian Liu , Kun She , Bao-Qi Zhang , Heng-ShanWang*, Hai-Tao Tang*, Ying-Ming Pan*. Photocatalyst-controlled and visiblelight-enabled selective oxidation of pyridinium salts. Scie. ChinaChem., 2021,64(5): 1-8.

7.       Meng Wang, Guimei Li,Guiyang Jiang, Jingyuan Cai, Wentian Zhong, Rizhen Huang, Zhikun Liu*, XiaochaoHuang*, Heng-Shan Wang*. Dual-targeting tumor cells hybrids derived fromPt(IV) species and NF-κB inhibitors enables cancer therapy throughmitochondrial dysfunction and ER stress and overcomes cisplatin resistance. Eur. J Med. Chem., 2024, 266, 116095.

8.    Xiaochao Huang, Yuanhang Chen, Wentian Zhong, Zhikun Liu*, Haijiang Zhang,Bin Zhang*, Hengshan Wang*. Novel combretastatin A-4 derivativecontaining aminophosphonates as dual inhibitors of tubulin and matrixmetalloproteinases for lung cancer treatment. Eur. J Med. Chem., 2022, 244:114817.

9.    Xiaochao Huang*, Meng Wang, Qinghong You, Jing Kong, Haijiang Zhang,Chunhao Yu, Yanming Wang, Hengshan Wang*, Rizhen Huang*. Synthesis,mechanisms of action, and toxicity of novel aminophosphonates derivativesconjugated irinotecan in vitro and in vivo as potent antitumor agents. Eur.J. Med. Chem., 2020, 189, 112067.

10.    Xiao-Chao Huang, Xiaochao Huang, Rizhen Huang, Zhimei Wang, Lingxue Li,Shaohua Gou*, Zhixin Liao, Heng-Shan Wang*. Pt(IV) complexesconjugating with chalcone analogue as inhibitors of microtubule polymerizationexhibited selective inhibition in human cancer cells. Eur. J. Med. Chem.,2018,146, 435-450.

11.    XiaochaoHuang, Shixian Hua, Rizhen Huang, Zhikun Liu, Shaohua Gou*, Zhimei Wang, ZhixinLiao, Hengshan Wang*. Dual-targeting antitumor hybrids derived from Pt(IV)species and millepachine analogues. Eur. J. Med. Chem.,2018,148, 1-25.

12.    Ri-ZhenHuang, Gui-Bin Liang, Xiao-Chao Huang, Bin Zhang, Mei-Mei Zhou, Zhi-Xin Liao*, Heng-ShanWang*.Discovery of dehydroabietic acid sulfonamide based derivatives as selectivematrix metalloproteinases inactivators that inhibit cell migration andproliferation. Eur. J. Med. Chem., 2017, 138,979-992.

13.    XiaochaoHuang, Rizhen Huang, Lingxue Li, Shaohua Gou, Hengshan Wang*. Synthesisand biological evaluation of novel chalcone derivatives as a new class ofmicrotubule destabilizing agents. Eur. J. Med. Chem., 2017, 132, 11-25.

14.    Jian-MeiQin, Ri-Zheng Huang, Xiao-Chao Huang, Gui-Yang Yao, Ying-Ming Pan* and Heng-Shan Wang*. Terminal functionalized thiourea-containing dipeptides asmultidrug- resistance reversers that target 20S proteasome and cellproliferation. Eur. J. Med. Chem., 2017, 126, 259-269.

15.    Man-YiYe, Gui-Yang Yao, Ying-Ming Pan, Zhi-Xin Liao, Ye Zhang, Heng-Shan Wang*. Synthesis and antitumor activities of novelα-aminophosphonate derivatives containing an alizarin moiety. Eur.J. Med. Chem., 2014, 83,116–128.

16.    Jian-FeiLi, Ri-Zhen Huang, Gui-Yang Yao, Man-Yi Ye,Heng-Shan Wang*, Ying-Ming Pan*, Jing-Teng Xiao. Synthesis and biologicalevaluation of novel aniline-derived asiatic acid derivatives as potentialanticancer agents. Eur. J. Med. Chem., 2014, 86,175–188.

17.    Hong-EnQu , Ri-Zhen Huang, Gui-Yang Yao, Jiu-Ling Li, Man-Yi Ye, Heng-Shan Wang*, Liangxian Liu*. Synthesis and pharmacologicalevaluation of novel bisindole derivatives bearing oximes moiety: Identificationof novel proapoptotic agents, Eur. J. Med. Chem., 2015, 95, 400−415.

18.    Xiao-Chao Huang, Le Jin, Meng Wang, Dong Liang,Zhen-Feng Chen, Ye Zhang*,Ying-Ming Pan, Heng-Shan Wang*. Design, synthesis and in vitroevaluation of novel dehydroabietic acid derivatives containing a dipeptidemoiety as potential anticancer agents. Eur.J. Med. Chem., 2015, 89, 370−385.

19.    Shi-XianHua, Ri-Zheng Huang, Man-Yi Ye, Ying-Ming Pan, Gui-Yang Yao, Ye Zhang*, Heng-Shan Wang*, Design, synthesis andin vitro evaluation of novel ursolic acid derivatives as potential anticanceragents. Eur. J. Med. Chem.,2015, 95, 435−452.

20.    XiaochaoHuang, Rizheng Huang, Zhixin Liao, Yingming Pan, Shaohua Gou*, Hengshan Wang*.Synthesis and pharmacological evaluation of dehydroabietic acid thioureaderivatives containing bisphosphonate moiety as an inducer of apoptosis. Eur.J. Med. Chem., 2016, 108, (27), 381-391.

21.    Xiao-ChaoHuang, Meng Wang, Ying-Ming Pan, Gui-Yang Yao, Heng-Shan Wang*, Xiao-Yan Tian, Jiang-Ke Qin, Ye Zhang. Synthesisand antitumor activities of novel thiourea α-aminophosphonates fromdehydroabietic acid. Eur. J. Med. Chem., 2013, 69,508–520.

22.    Lumei Dai , Feng Qin , Yuying Xie, Bin Zhang, Zhijie Zhang, Sijia Liang,Fujia Chen, Xiaochao Huang*, Hengshan Wang*. Antitumor activityand mechanisms of dual EGFR/DNA-targeting strategy for the treatment of lungcancer with EGFRL858R/T790M mutation. Bioorg. Chem., 2023,135:106510.

23.    Meng Wang, Zhikun Liu, Xiaochao Huang, Yuanhang Chen, Yanming Wang, JingKong, Yong Yang, Chunhao Yu, Jin Li, Xu Wang*, Hengshan Wang*.Dual-target platinum(IV) complexes exhibit antiproliferative activity throughDNA damage and induce ER-stress-mediated apoptosis in A549 cells. Bioorg. Chem., 2021, 110: 104741-104741.

24.    XiaochaoHuang*, Meng Wang, Chungu Wang, Weiwei Hu, Qinghong You, Tianhua Ma, Qiang Jia,Chunhao Yu, Zhixin Liao*, Hengshan Wang*. Synthesis and biologicalevaluation of novel millepachine derivative containing aminophosphonate esterspecies as novel anti-tubulin agents. Bioorg. Chem., 2020, 94,103486.

25.    Le Jin,Lumei Dai,Min Ji*,Hengshan Wang*. Mitochondria-targeted triphenylphosphonium conjugatedglycyrrhetinic acid derivatives as potent anticancer drugs. Bioorg. Chem., 2019,85, 179-190.

26.    Xiaochao Huang, Meng Wang, Chungu Wang, Weiwei Hu, Qinghong You, Yong Yang,Chunhao Yu, Zhixin Liao, Shaohua Gou*, Hengshan Wang*, Dual-targetingantitumor conjugates derived from platinum(IV) prodrugs and microtubuleinhibitor CA-4 signifcantly exhibited potent ability to overcome cisplatinresistance. Bioorg. Chem., 2019, 92: 1032362.

27.    HuangX, Liu Z, Wang M, Yin X, Wang Y, Dai L, Wang H*.Platinum(IV) complexes conjugated with chalcone analogs as dual targetinganticancer agents: In vitro and in vivo studies. Bioorg. Chem.,2020 , 105:104430.

28.    Cai-Wen Fan, Mei-Shan Li, Xi-Xi Song, Li Luo, Jing-Chen Jiang, Jia-Zi Luo*,Heng-Shan Wang*. Discovery ofnovel 2-oximino-2-indolylacetamide derivatives as potent anticancer agentscapable of inducing cell autophagy and ferroptosis. Bioorg. Med. Chem., 2023, 80:117176.

29.    Le Jin,Rizhen Huang, Xiaochao Huang, Bin Zhang, Min Ji* and Hengshan Wang*,Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivativesas Hsp90–Cdc37 interaction disruptors that inhibit cell migration and reversedrug resistance. Bioorgan. Med. Chem., 2018, 26, 1759–1775

30.    Yu-YangXie, Ying-Chun Wang, Yan He, Da-Chao Hu, Heng-Shan Wang*, Ying-MingPan*. Catalyst-Free Synthesis of Fused 1, 2, 3-Triazole and IsoindolineDerivatives via Intramolecular Azide-Alkene Cascade Reaction. Green Chem., 2017, 19, 656–659.

31.    KunShe, Feng Liang, Shichao Tian, Hengshan Wang*, Gavin Chit Tsui, Quande Wang*.Organocatalytic Three-omponent Acyldifluoromethylation of Vinylarenes viaN-Heterocyclic Carbene-Catalyzed Radical Relay. Org. Lett., 2022,24: 4840-4844.

32.    Yong-Zhou Pan, Qiang Xia, Jin-Xiu Zhu, Ying-Chun Wang, Ying Liang, HengshanWang,* Hai-Tao Tang,* and Ying-Ming Pan*. Electrochemically MediatedCarboxylative Cyclization of Allylic/Homoallylic Amines with CO2 atAmbient Pressure. Org. Lett., 2022, 24, 8239−8243.

33.   Yan He, Yingchun Wang, Xinping Liang, BinHuang, Hengshan Wang*, and Ying-Ming Pan*. Palladium-CatalyzedThree-Component Reaction: A Novel Method for the Synthesis of N‑AcylPropiolamides .Org. Lett., 2018, 20, 22, 7117-7120.

34.   Xiao-Ying Huang, Rui Ding, Zu-Yu Mo, Yan-Li Xu, Hai-Tao Tang,Heng-Shan Wang*, Yan-Yan Chen, Ying-Ming Pan*. PhotocatalyticConstruction of S–S and C–S Bonds Promoted by Acridinium Salt: An UnexpectedPathway To Synthesize 1, 2, 4-Dithiazoles.Org. Lett., 2018, 20, 4819−4823.

35.   Jiu-ling Li, Wei-ze Li, Ying-chun Wang,Qiu Ren, Heng-shan Wang,* andYing-ming Pan*. Palladium(II)-Catalyzed C-C and C-O Bonds Formation for theSynthesis of C1-Benzoyl Isoquinolines from Isoquinoline N-Oxides and NitroAlkenes. Chem. Commun., 2016, 52,10028-10031.

36.   Jiu-ling Li,Ying-chun Wang, Wei-ze Li, Heng-shanWang*, Dong-liang Moa andYing-ming Pan*. Facile synthesis of 2,5‐disubstituted oxazoles via acoppercatalyzed cascade reaction of alkenes with azides. Chem. Commun., 2015, 51, 17772-17774.

37.   Bin Zhang,Xiaochao Huang,Hengshan Wang*,Shaohua Gou*. Promoting antitumor efficacy by suppressing hypoxia via nano self-assemblyof two irinotecan-based dual drug conjugates having a HIF-1α inhibitor. J. Mater. Chem. B, 2019, 7(35): 5352-5362.

38.    Xiaochao Huang, Rizhen Huang, Shaohua Gou, Zhimei Wang, Hengshan Wang*. Anticancer Platinum(IV) Prodrugs ContainingMonoaminophosphonate Ester as a Targeting Group Inhibit MatrixMetalloproteinases and Reverse Multidrug Resistance. Bioconjugate Chem., 2017, 28 (4),1305-1323.

39.   Xiaochao Huang, Rizhen Huang,Shaohua Gou*, ZhimeiWang, Zhixin Liao, Hengshan Wang*. Combretastatin A-4Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt (IV)Moiety with a Unique Mode of Action. BioconjugateChem., 2016, 27(9): 2132-2148.

40.    Yan He,Ying-Chun Wang, Kun Hu, Xiao-Ling Xu, Heng-Shan Wang*, Ying-Ming Pan*.Palladium-Catalyzed Synthesis of 5-Iminopyrrolones through Isocyanide DoubleInsertion Reaction with Terminal Alkynes and Water. J. Org. Chem., 2016, 81(23), 11813-11818.

41.    Yan-liXu, Ying-Ming Pan,* Qiang Wu, Heng-ShanWang*, Pei-zhen Liu. Regioselective Synthesis of 1,3,5-Substituted Benzenesvia the InCl3/2-iodophenol- Catalyzed Cyclotrimerization of Alkynes.J.Org. Chem. 2011, 76(20),8472-08476.

42.    Ying-ChunWang, Yu-Yang Xie, Hong-En Qu, Heng-ShanWang*, Ying-Ming Pan*, Fu-Ping Huang. Ce(OTf)3-catalyzed [3+2]cycloaddition of azides with nitroolefins: regioselective synthesis of1,5-disubstituted 1,2,3-triazoles. J. Org. Chem., 2014, 79, 4463−4469.

43.    Jiu-lingLi, Da-chao Hu, Xin-ping Liang, Ying-Chun Wang, Heng-Shan Wang*,Ying-ming Pan*. Praseodymium (III)-Catalyzed Regioselective Synthesis ofC3-N-substituted Coumarins with Coumarins and Azides. J. Org. Chem.,2017, 82, 9006−9011.

44.    Xiu-Jin Meng, Ping-Fu Zhong, Yu-Mei Wang, Heng-Shan Wang*, Hai-TaoTang*, Ying-Ming Pan*.ElectrochemicalDifunctionalization of Olefines: Access to Selenomethyl-Substituted CyclicEthers or Lactones.Adv. Synth. Catal., 2020,362:506-511.

45.    YingchunWang, Jiuling Li, Yan He, Yuyang Xie, HengshanWang,* and Yingming Pan,* Synthesis of Polysubstituted Imidazoles andPyridines via Samarium(III) Triflate-Catalyzed [2+2+1] and [4+2] Annulations ofUnactivated Aromatic Alkenes with Azide.Adv. Synth. Catal., 2015, 357, 3229-3241.

46.    Yu-YangXie, Ying-Chun Wang, Hong-En Qu, Xian-Chun Tan, Heng-Shan Wang*, Ying-Ming Pan*. Regioselective synthesis ofβ-Aryl enaminones and 1,4,5-trisubstituted 1,2,3-triazoles from chalcones andbenzyl azides. Adv. Synth. Catal., 2014,356, 3347–3355.

47.    PeiLiu, Ying-Ming Pan*, Yan-Li Xu, Heng-ShanWang*. PTSA-catalyzed Mannich-type-cyclization-oxidation tandem reactions:one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines andalkynes. Org. Biomol. Chem., 2012, 10, 4696–4698.

48.   Xu Wang, Ying-ming Pan*, Xiao-chao Huang, Zhong-yuanMao and Heng-shan Wang*. A novelmethodology for synthesis of dihydropyrazole derivatives as potentialanticancer agents. Org. Biomol. Chem., 2014, 12, 2028-2032.

49.    Xiaoguang Pan, Min Cao, Song Li, Hengshan Wang*, Xigong Liu*, andLei Liu*. Synthesis of Diarylmethanes Bearing CF3- and CN-Substituted All-carbonQuaternary Centers and Diarylmalononitriles through Cyanation ofδ-Disubstituted Para-Quinone Methides. Eur. J. Org. Chem., 2021, 1643-1646.

50.   Wei-Gen Huang, Heng-Shan Wang*, Guo-Bo Huang, Yong-Ming Wu, Ying-Ming Pan*. Enantioselective friedel–craftsalkylation of n‐methylindoles with nitroalkenes catalyzed by chiralbifunctional abietic‐acid‐derived thiourea‐ZnII complexes. Eur.J. Org. Chem., 2012, 29, 5839–5843.

51.    Gui-YangYao, Ya-Jun Li, Yong-Tao Zhu, Ying-Ming Pan, Fu-Ping Huang, Hengshan Wang*, Zhi-Xin Liao*.Protonation-controlled axial chirality in maleopimaric imides. NewJ. Chem., 2014, 38, 693–699.

52.    Heng-Shan Wang*,Xiao-Yan Tian, Da Yang, Ying-Ming Pan, Qiang Wu, Chun-Huan He. Synthesis andenantiomeric recognition ability of 22-crown-6 ethers derived from rosin acidand BINOL. Tetrahedron: Asymmetry, 2011, 22(4), 381–386.

53.     Jia-Jia Liu, Bao-Qi Zhang, Kun She, JiaoRan, Hui-Fang Li, Heng-Shan Wang, Fang-Xin Wang*, Heng-Shan Wang*.Divergent syntheses of (-)-carvone-derived dimers. Tetrahedron, 2024, 151,133804.

54.    Qi Gao,Shen-Yan Li, Ying-Ming Pan*, Yan-Li Xu, Heng-ShanWang*. The indium-catalysed hydration of alkynes using substoichiometricamounts of PTSA as additive. Tetrahedron, 2013, 69(19),3775–3781.

55.    PeiLiu, Ying-Ming Pan*, Kun Hu, Xiao-Chao Huang, Ying Liang, Heng-Shan Wang*. Ligand-free indium(III)-catalyzed Heck reaction. Tetrahedron,2013, 69(37), 7925–7930.

56.     Ying-Chun Wang, Heng-Shan Wang*, Guo-BaoHuang, Fu-Ping Huang, Kun Hu, Ying-Ming Pan*. A one-pot approach to4,5-dihydropyrazoles from ketones, arylacetylenes, and hydrazines. Tetrahedron,2014, 70, 1621–1628.

57.     Lu-Zhi Liu, Chun-Huan He, Lin Yang, Yan Huang,Qiang Wu, Wen-gui Duan, Heng-shan Wang*,Ying-ming Pan*. Novel C1-symmetric chiral crown ethers bearing rosin acidsgroups: synthesis and enantiomeric recognition for ammonium salts. Tetrahedron,2014, 70, 9545–9553.

58.    Ri-Zhen Huang, Gui-Bin Liang, Mei-Shan Li, Yi-Lin Fang, Shi-Feng Zhao,Mei-Mei Zhou, Zhi-Xin Liao*, Jing Sun* and Heng-Shan Wang*. Synthesisand discovery of asiatic acid based 1,2,3-triazole derivatives as antitumoragents blocking NF-κB activation and cell migration. Med. Chem. Commun.,2019, 10:584-597.

天然药物化学方向

59.     Cai-Wen Fan, Juan Tang , Jing-Chen Jiang , Mei-Mei Zhou , Mei-Shan Li*, Heng-ShanWang*, Pentagalloylglucose suppresses the growth and migration of humannasopharyngeal cancer cells via the GSK3β/β-catenin pathway in vitro and invivo. Phytomedicine, 2022. 102: 154192.

60.    Xi-Lin Ouyang, Feng Qin, Ri-Zhen Huang, Dong Liang,Chun-Gu Wang, Heng-Shan Wang*, Zhi-Xin Liao*. NF-κB inhibitory andcytotoxic activities of hexacyclic triterpene acid constituents from Glechomalongituba. Phytomedicine,2019, 63, 153037

61.    Ri-ZhenHuang, Xiao-Chao Huang, Bin Zhang, Hai-Yang Jia, Zhi-XinLiao*, Heng-ShanWang*.16-O-caffeoyl-16-hydroxylhexadecanoic acid, a medicinal plant-derived phenylpropanoid, induces apoptosis in humanhepatocarcinoma cells through ROS-dependent endoplasmic reticulum stress. Phytomedicine,2018, 41, 33-44.

62.    Bin Zhang, Rizhen Huang,Jing Hua, Hong Liang, Yingming Pan, Lumei Dai, Dong Liang, Hengshan Wang*.Antitumor lignanamides from the aerial parts of Corydalis saxicola. Phytomedicine, 2016, 23(13), 1599-1609.

63.    Cai Yi Wang, Feng Qin, Chun-Gu Wang, Donghwa Kim, Jin-Jun Li, Xian-LanChen, Heng-Shan Wang*, Lee SK*. Novel lignans from Zanthoxylum nitidumand antiproliferation activity of sesaminone in osimertinib-resistant non-smallcell lung cancer cells. Bioorg Chem., 2023, 134:106445.

64.    Wei Jiang, Ri-ZhenHuang, Jing Zhang, Tong Guo, Meng-Ting Zhang, Xiao-Chao Huang, Bin Zhang,Zhi-Xin Liao*, Jing Sun*, Heng-Shan Wang*. Discovery of antitumorursolic acid long-chain diamine derivatives as potent inhibitors of NF-κB.Bioorg.Chem., 2018, 79,265-276.

65.    FengQin, Li Luo, Yu-Chen Liu, Xiang-Long Bo, Fu-Rong Wu, Fan-Fan Wang, Mei-JingTan, You-Quan Wei, Xiao-Bing Dou, Cai Yi Wang, Xi-Shan Huang*,Heng-Shan Wang*.Diisoprenyl-cyclohexene-type meroterpenoids from a mangrove endophytic fungusAspergillus sp. GXNU-Y65 and their anti-nonalcoholic steatohepatitis activityin AML12 cells. Phytochemistry, 2024, 218, 113955.

66.    Feng Qin, Cai YiWang, Chun-Gu Wang, Yao Chen, Jin-Jun Li, Mei-Shan Li, Yan-Kui Zhu, Sang KookLee*, Heng-Shan Wang*. Undescribed isoquinolines from Zanthoxylum nitidum and theirantiproliferative effects against human cancer cell lines. Phytochemistry, 2023, 205:113476.

67.    Lu-Mei Dai, Ri-Zhen Huang, Bin Zhang, Jing Hua, Heng-Shan Wang*, Dong Liang*, CytotoxicTriterpenoid Saponins from Lysimachia foenum-graecum. Phytochemistry, 2017, 136 , 165-174.

68.    Feng Qin, Li Luo, Yao Chen, Gang Wei, Chun-Ce Wei, Xiao-Hua Yang, Yi-LinFang, Heng-Shan Wang*. A newphenylpropanoic acid congener from Zanthoxylum nitidum. Nat. Prod. Res., 2023, 9:1-7.

69.    Feng Qin, Zi-Shuo Song, Li Luo, Xiang-Long Bo, Fu-Rong Wu, Mei-Jing Tan,Fan-Fan Wang, Xi-Shan Huang*, Heng-Shan Wang*. DiisoprenylCyclohexene-Type Meroterpenoids with Cytotoxic Activity from a MangroveEndophytic Fungus Aspergillus sp. GXNU-Y85. Marine Drugs,2024, 22, 58.

70.    WentaoSun, Li Luo, Jiazi Luo, Xixi Song, Demin Tang , Zishuo Song ,Meishan Li*, Hengshan Wang*.Phytoconstituents of Selaginella effusa Alston and Their α-Glucosidase as wellas Urease Inhibitory Activities.Chem. Biodivers.,2023, 20, e202300387.

71.    Xi-Lin Ouyang, Tian-Hua Ma, Gui-Liang Xie, Shan Chen, Heng-Shan Wang*,Qiang Jia, En-De Zhang, and Jing-Hua Huang. Acetylated rhamnose triterpenoidsaponins from Glechoma longituba analyzed by LC-Q-TOFMS.Chem. Biodivers.,2021, 18: e2100272.

72.    Feng Qin, Mei-Shan Li, Jin-Jun Li, Yue Wang, Ke Wang, Jian-Yu Zhou, DongLiang*, Heng-Shan Wang*. Four New Sesquiterpenoids from Zanthoxylumnitidum. Chem. Biodivers., 2022, 19: e202200449.

73.    Fanfan Wang, Ming Li, Cong Lin, Sha Jin, Hongyuan Li, Yuyuan Lu, HengshanWang*, Hongshuang Wang*, Xiaohui Wang*. Cannabidiol-dihydroartemisininconjugates for ameliorating neuroinflammation with reduced cytotoxicity. Bioorg. Med. Chem., 2021, 39: 116131-116131.

74.    Wei-NaYao, Ri-Zhen Huang, Jing Hua, Bin Zhang, Chun-Gu Wang, Dong Liang*, Heng-ShanWang*. Selagintamarlin A, A 1H-2-BenzopyranSelaginellin Analogue Possessing an Unprecedented Skeleton from Selaginella tamariscina. ACS Omega, 2017,2 (5): 2178–2183.

75.    Lu-MeiDai, Ri-Zhen Huang, Jinjin Zhu, Zi-Shuo Song, Zhao-Guo Hong, Feng Qin*, HengshanWang*. Targeted isolation, structural characterization and cytotoxicityevaluation of isoquinoline alkaloids from Corydalis Saxicola. Journal ofMolecular Structure, 2023,  1293,136240.

76.    Feng Qin, Lumei Dai, Bin Zhang, Rizhen Huang, Fanfan Wang, Jiangke Qin,Dong Liang*, Hengshan Wang*. (±)-Corysaxicolaine A: a pair of antitumorenantiomeric alkaloid dimers from Corydalis saxicola. Org. Biomol. Chem., 2022, 20:1396-1400.

77.    Ying-chun Wang, Yu-yang Xie, Xian-chun Tan, Heng-shan Wang*, Ying-ming Pan*.Sc(OTf)3-mediated 1,3-dipolar cycloaddition-ringcleavage-rearrangement: a highly stereoselective access toZ-beta-enaminonitriles. Org. Biomol. Chem., 2015, 13, 513−519.

78.   Li Luo, Jia-Zi Luo,Xi-Xi Song, Cai-Yi Wang, De-Ming Tang, Wen-Tao Sun, Cai-Wen Fan, Mei-Shan Li*, Heng-ShanWang*. Alkaloids from Corydalis saxicola and theirantiproliferative activity against cancer cells. Fitoterapia,2024, 173, 105791.

79.    Feng Qin, Chun-Gu Wang, Mei-Shan Li, Jin-Jun Li, Gang Wei, Na Liao, Heng-ShanWang*. Structurally diverse isobutylamides from Zanthoxylum nitidum. Fitoterapia,2023, 164:105381.

80.    Jia-Zi Luo, Mei-Shan Li, Xi-Xi Song, Yi-Lin Fang, Hai-Ning Mo, Jing-ChenJiang, Hai-Yan Zhao, Heng-Shan Wang*. New alkaloids and their in vitroantitumor activity of Corydalis balansae. Fitoterapia, 2022, 162:105289.

81.    Feng Qin, Fan-Fan Wang, Chun-Gu Wang, Yao Chen, Mei-Shan Li, Yan-Kui Zhu,Xiao-chao Huang, Cai-Wen Fan*, Heng-Shan Wang*. The neurotrophic and antineuroinflammatory effects of phenylpropanoidsfrom Zanthoxylum nitidum var. tomentosum (Rutaceae). Fitoterapia,2021,153: 104990.

82.    Xi-LinOuyang, Wen-Hua Mao, Chun-Gu Wang, Ying-Ming Pan, Dong Liang*, Heng-Shan Wang*.Fivenew 11α, 12α-epoxy pentacyclic triterpenoid saponins with anticoagulant activities from Glechomalongituba.Fitoterapia, 2019, 138: 104345

83.    YuanZhu, Ri-Zhen Huang, Chun-Gu Wang, Xi-Lin Ouyang, Xiao-Teng Jing, Dong Liang*,and Heng-Shan Wang*. New inhibitorsof matrix metalloproteinases 9 (MMP-9): lignans from Selaginella moellndorffii. Fitoterapia,2018,130: 281–289

84.    Ri-Zhen Huang, Le Jin,Chun-Gu Wang, Xiao-Jing Xu, Ying Du, Na Liao, Min Ji, Zhi-Xin Liao*, Heng-ShanWang*. A pentacyclic triterpene derivative possessing polyhydroxyl ring Asuppresses growth of HeLa cells by reactive oxygen species-dependent NF-κB pathway.Eur.J. Pharmacol., 2018, 838: 157-169.

85.    Chun-GuWang, Wei-Na Yao, Bin Zhang, Jing Hua, Dong Liang*, Heng-Shan Wang*. Lungcancer and matrix metalloproteinases inhibitors of polyphenols from Selaginellatamariscina with suppression activity of migration. Bioorg. Med. Chem. Lett., 2018, 28, 2413-2417.

86.    Lu-Mei Dai, Ri-ZhenHuang, Bin Zhang, Jing Hua, Hai-Bing Liao, Heng-Shan Wang*, Dong Liang*, Threenew triterpenoid saponins from the aerial parts of Lysimachia foenumgraecum.  PhytochemistryLetters, 2017, 22, 133-137.

87.    Cai YiWang, Ji Sun Lee, Xiang Dong Su, Hong Xu Li, Sang Kook Lee, Heng-Shan Wang*Young Ho Kim* and Seo Young Yang*. Three new constituents from the aerial partsof Tetrastigma hemsleyanum and theircytotixic and soluble epoxide hydrolase inhibitory activities. Phytchem.Lett., 2018, 27: 25-29.

88.   Ri-Zhen Huang, Bin Zhang, Xiao-ChaoHuang, Gui-Bin Liang, Jian-Mei Qin, Ying-Ming Pan, Zhi-Xin Liao*, Heng-Shan Wang*. Synthesis and biological evaluation of terminalfunctionalized thiourea-containing dipeptides as antitumor agents.RSCAdvances,2017, 7(15),8866-8878

89.    QiangWu, Pei Liu, Ying-Ming Pan*, Yan-Li Xu, Heng-ShanWang*. Cu (otf) 2-catalyzed three-component annulation reaction: One-potsynthesis of 4, 5-dihydropyrazole from aldehydes, hydrazines and alkenes. RSCAdvances. 2012, 2: 10167–10170.

90.    Ri-Zhen Huang, Cai-YiWang, Jian-Fei Li, Gui-Yang Yao, Ying-Ming Pan, Man-Yi Ye, Heng-Shan Wang*, Ye Zhang*. Synthesis, antiproliferative andapoptosis-inducing effects of novel asiatic acid derivatives containingα-aminophosphonates.RSC Advances.,2016, 6: 62890–62906.

91.    Yan He,Yu-yang Xie, Ying-chun Wang, Xiao-min Bin, Da-chao Hu, Heng-shan Wang*,Ying-ming Pan*. TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylicketones and TMSN.RSC Advances, 2016, 6(64),58988-58993.

92.   Na Liao, Mei-Shan Li,Feng Qin*, Jing-Chen Jiang, Ri-Da Luo, Xian-Lan Chen, Mei-Mei, Zhou, Yan-Kui Zhu, Heng-ShanWang*. A new phenolic acid from Zanthoxylum nitidum var. tomentosum (Rutaceae)and its chemotaxonomic significance. Biochem.Syst. Ecol., 2021,99, 104351.

93.   Gui-yang Yao, Man-yiYe, Ri-zhen Huang, Ya-jun Li, Yong-tao Zhu, Ying-ming Pan, Zhi-Xin Liao*, Heng-shan Wang*. Synthesis andantitumor activity evaluation of maleopimaric acid N-aryl imide atropisomers. Bioorg.Med. Chem. Lett., 2013, 23, 6755-6758

94.    Gui-YangYao, Man-Yi Ye, Ri-Zhen Huang, Ya-Jun Li, Ying-Ming Pan, Qing Xu, Zhi-XinLiao*, Heng-Shan Wang*.Synthesis and antitumor activities of novel rhein α-aminophosphonatesconjugates. Bioorg. Med. Chem. Lett., 2014, 24, 501–507

95.    Xiao-ChaoHuang, Meng Wang, Heng-Shan Wang,Zhen-Feng Chen, Ye Zhang*, Ying-Ming Pan*. Synthesis and antitumor activitiesof novel dipeptide derivativesderived from dehydroabietic acid. Bioorg.Med. Chem. Lett., 2014, 24,1511–1518.

96.    Xiao-ChaoHuang, Meng Wang, Ying-ming Pan, Xiao-Yan Tian, Heng-shan Wang*, Ye Zhang*. Synthesis and antitumor activities ofnovel α-aminophosphonates dehydroabietic acid derivatives. Bioorg. Med. Chem. Lett.,2013, 23(19), 5283–5289.

97.   Pan, Yingming*; He,Chunhuan; Wang, Hengshan*; Ji,Xiaowen; Wang, Kai; Liu, Peizhen Antioxidant activity of microwave-assistedextract of Buddleia officinalis and its major active component. FoodChemistry,2010, 121, 15, 497–502.

98.   Yingming Pan,*, Zhiren Zhu, Zhili Huang, Hengshan Wang*, Ying Liang, Kai Wang,Qian Lei, Min Liang. Characterisation and free radical scavenging activities ofnovel red pigment from Osmanthus fragrans’seeds. Food Chemistry, 2009, 112: 909–913.

99.   Yingming Pan*, Kai Wang, SiqinHuang, Hengshan Wang*, Xiaomei Mu, Chunhuan He, Xiaowen Ji, Jie Zhangand Fujuan Huang. Antioxidant activity of microwave- assisted extract of longan(Dimocarpus Longan Lour.) peel.Food Chemistry, 2008, 106(3): 1264-1270.

100.YingmingPan*, Jinchan Zhu, Hengshan Wang*,Xiaopu Zhang, Ye Zhang, Chunhuan He, Xiaowen Ji, Haiyun Li. Antioxidantactivity of ethanolic extract of Cortex fraxini and use in peanut oil.Food Chemistry,2007,103: 913–918.

101.  Yingming Pan*, Xiaopu Zhang, Hengshan Wang*, Ying Liang, JinchanZhu, Haiyun Li, Zhi Zhang, Qingmao Wu. Antioxidantpotential of ethanolic extract ofPolygonum cuspidatum and application in peanut oil. Food Chemistry, 2007, 105(4):1518-1524.

102.   Heng-Shan Wang*, Dian-Hua Gan,Xiao-Pu Zhang, Ying-Ming Pan. Antioxidant capacity of the extracts from pulp ofOsmanthus fragrans and its components. LWT - Food Sci. Technol.2010, 43, 319–325.

103.    Ming-Xiong Tan, Dian-hua Gan, Liu-xin Wei,Ying-ming Pan, Shao-qing Tang, Heng-shanWang*. Isolation and characterization of pigment from Cinnamomum burmannii’peel. Food Res. Int. 2011, 44: 2289–2294.

104.    Qi-Ming Pan, Yu-Huan Li, Jing Hua, Fu-PingHuang, Heng-Shan Wang, Dong Liang*. Antiviral Matrine-type Alkaloidsfrom the Rhizomes of Sophora tonkinensis. J. Nat. Prod., 2015, 78(7),1683-1688.

105.     Le Jin, Hong-En Qu, Xiao-Chao Huang,Ying-Ming Pan, Dong Liang, Zhen-Feng Chen, Heng-ShanWang,* and Ye Zhang*. Synthesis and Biological Evaluation of Novel Dehydroabietic AcidDerivativesConjugated with Acyl-Thiourea Peptide Moiety as AntitumorAgents, Int.J. Mol. Sci.2015, 16, 14571-14593.

106.    Man-Yi Ye, Gui-Yang Yao, Jing-Chen Wei,Ying-Ming Pan*, Zhi-Xin Liao, Heng-ShanWang*. Synthesis, cytotoxicity, DNA binding and apoptosis of rheinphosphonate derivatives as antitumor agents. Int. J. Mol. Sci., 2013,14, 9424–9439.

107.    Guiyang Yao, Manyi Ye, Yongtao Zhu, ZhixinLiao*,Hengshan Wang*.Synthesis and pharmacological evaluation of maleopimaric N-arylimides:Identification of novel proapoptotic agents, Anti-Cancer Agent. Med. Chem.,2016, 16(6), 755-762. 

108.     Huang, R.Z., Hua, S. X., Wang, C. Y., Pan, Y. M., Qin, J. M., Ding, Z. Y., Zhang, Y*.& Wang, H. S*. 4-MethylumbelliferonesAnalogues as Anticancer Agents: Synthesis and in Cell Pharmacological Studies.Anti-Cancer Agent. Med. Chem., 2017, 17(4), 576-589.

109.     Pingtan Lin, Shulin Zhao*, Xin Lu, Fanggui Ye,Hengshan Wang*. Preparationof a dual- enzyme co-immobilized capillary microreactor and simultaneousscreening of multiple enzyme inhibitors by capillary electrophoresis,J. Sep. Sci., 2013, 36(15): 2538–2543.

110.     Ying-Chun Wang, Chun-Hua Su, Fang-Yao Li,Lu-Zhi Liu, Ying-Ming Pan, Xiu-Rong Wu, Heng-Shan Wang*. Syntheses,characterization and fluorescent properties of two series of dehydroabieticacid C-ring derivatives. Spectrochim. Acta A, 2010, 76, 328–335.

111.     Xi-Lin Ouyang, L-X Wei , Heng-Shan Wang*, Ying-Ming Pan*.Antioxidant activity and phytochemical composition of Osmanthus fragrans'pulps. S. Afr. J. Bot., 2015, 98: 162–166.

112.     XLOuyang, XM Fang, YM Pan, LX Wei, HS Wang*, Development of HPLCFingerprint for the Quality Control of Euonymusfortunei and Distinguishing from Related Species. Acta Chromatogr.,2012, 24(2): 301-316.

113.     Rui-Yun Yang, Xi-Lin Ouyang, Dian-Hua Gan, Heng-Shan Wang*, Yi-Zheng Li, Ying-MingPan*. Isolation and Determination of Iridoid Glycosides From the Seeds of Osmanthus fragrans by HPLC.Anal.Lett., 2012, 46: 745–752.

114.     Xi-LinOuyang,, Liu-Xin Wei, Xian-Ming Fang, Heng-ShanWang*, Ying-Ming Pan*. Flavonoid constituents of Euonymus fortune. Chem. Nat. Compd., 2013, 49(3),428–431.

115.     Yi-Zheng Li,Ying-Ming Pan, Xiao-Yan Huang, Heng-ShanWang*. Withanolides from Physalis alkekengi var. francheti. Helv.Chim. Acta. 2008, 91: 2284－2291.

116.     Hengshan Wang, Shulin Zhao*, Min He, Zhicai Zhao, Yingming Pan, QianLiang. Sodium maleopimaric acid as pseudostationary phasefor chiral separations of amino acids derivatives by capillary micellarelectrokinetic chromatography. J. Sep. Sci., 2007, 30:2748-2753.

117.     Hengshan.Wang, Rongcan Zhang, Shulin Zhao*, Lidong Tang and YingmingPan. Synthesis and application of dehydroabietylisothiocyante as a newchiralderivatizing agent for the enantiomeric separation of chiral compounds bycapillary electrophoretic. Anal. Chim. Acta2006, 560: 64–68.

118.     Shulin Zhao*, Rongcan Zhang, Hengshan Wang*,Lidong Tang and Yingming Pan. Capillary electrophoresis enantioselectiveseparation of vigabatrin enantiomers by precolumn derivatization. J.Chromatogr. B, 2006, 833 : 186–190.