陈明 博士
基础医学教授、博士生导师、广西杰出青年基金获得者、广西师范大学“漓江学者”，省部共建药用资源化学与药物分子工程国家重点实验室“药理学平台”负责人，“心血管分子药理”实验室PI。2007年毕业于中国人民解放军军事医学科学院；2011-2015年在美国托马斯杰斐逊大学医学院转化医学中心从事博士后研究，主要从事心血管药理及疾病蛋白质组学研究。2016年加入广西师范大学省部共建国家重点实验室，组建心血管分子药理实验室，目前主持国家自然科学基金项目2项（面上项目与地区项目各1项）、广西自然科学基金2项（回国基金重点项目与广西杰青项目各1项）以及省部共建国家重点实验室主任基金1项。迄今，已在 Circulation Research, Cardiovascular Research, European Journal of Pharmacology, J Med Chem., J. Biol. Chem, Mol. Biol.Cell, J Proteome Research, Proteomics, Journal of Molecular and Cellular Cardiology, AJP- Heart and Circulatory Physiology, Am J Respir Cell Mol Biol等心血管和蛋白质组学专业杂志发表论文30多篇。
电邮：chenmingprotein@mailbox.gxnu.edu.cn
主要研究方向：
1.炎症疾病与免疫微环境
2.心血管疾病的分子机制
3.疾病动物模型构建及药物筛选
4.疾病蛋白质组学及生物标志物发现
教育背景
2004/09-2007/07解放军军事医学科学院，放射与辐射医学研究所／北京蛋白质组学研究中心，博士
2001/09-2004/07南京农业大学，生命科学学院/生物化学与分子生物学系，硕士
1997/09-2001/07长江大学，动物科学学院/动物科学系，学士
工作经历
2017.01- 广西师范大学/化学与药学学院，教授，博士生导师
2016.05-2016.12广西师范大学/化学与药学学院，“漓江学者”，药理实验室PI
2011/04-2015/10 美国托马斯杰弗逊大学/医学院，转化医学中心，博士后研究员
2007/07-2011/01军事医学科学院/卫生与环境医学研究所，应激医学全军重点实验室，助理研究员
荣誉及奖励
2019，广西高校第二批“千名骨干教师培养计划”入选者
2018，广西杰出青年基金获得者
2016，广西师范大学“漓江学者”
发表论文
2022年
（37）Kan S, Li R, Tan Y, Yang F, Xu S, Wang L, Zhang L, Sun X, Chen X, Yang Y,Shu W, Wan H, Chen ZF, Liang H#, Chen M#. LXN deficiency attenuatesadipocyte differentiation and protects mice against obesity and metabolic disordersinduced by high-fat diet. Cell Death Dis.2022. 13(2)：175.（通讯作者）
（36）Li Y, Tan Y, Li X,Chen X, Wang L, Zhang L, Xu S, Huang K, Shu W, Liang H#, ChenM#. Loss of LXN PromotesMacrophage M2 Polarization and PD-L2 Expression Contributing CancerImmune-escape in Mice. Cell Death Discov. 2022.8(1): 440. （通讯作者）
2021年
(35)He G, Kan S,Xu S, Sun X, Li R, Shu W#, Chen M#. LXN deficiency regulates cytoskeleton remodeling by promotingproteolytic cleavage of Filamin A in vascular endothelial cells. J Cell Mol Med. 2021, 25(14):6815-6827. （#通讯作者）
2020年
(34)Liu H, Li D, Zhou L, Kan S, He G,Zhou K, Wang L#, Chen M#, Shu W#. LMNAfunctions as an oncogene in hepatocellular carcinoma via regulating theproliferation and migration ability.J Cell Mol Med. 2020,24(20):12008-12019（#通讯作者）
(33) Li Y, Huang B, Yang H，Kan S, Yao Y, Liu X, Pu S, HeG, Khan TM, Qi G, Zhou Z, Shu W#, Chen M #. Latexin deficiency in mice up-regulatesinflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway. Scientific Reports. 2020, 10(1): 9868.（#通讯作者）
(32) Nguyen T, Chen X, Chai J, Li R, Han X, Chen X, Liu S, Chen M#, Xu X#. Antipyretic,anti-inflammatory and analgesic activities of Periplaneta americana extract andunderlying mechanisms. Biomed Pharmacother. 2020, 123:109753.（#通讯作者）
(31) GulNS, Khan TM, ChenM, Huang KB,Hou C, Choudhary MI, Liang H, Chen ZF#. New copper complexes inducing bimodaldeath through apoptosis and autophagy in A549 cancer cells. J Inorg Biochem.2020, 213:111260. doi: 10.1016/j.jinorgbio.2020.111260.
2019年
(30)Huang B,Yao Y, Li Y, Yang H, Liu H, Liu H, Li D, Shu W#, Chen M#.Proteomics Approach to Investigate Dynamic Protein. Profile Involved in High Fat Diet–inducedFatty Liver Disease in Rats. JToxicol Pathol. 2019,32(4):223-232.（#通讯作者）
2018年
(29) Zeng B, Chai J, Deng Z, Ye T, Chen W, Li D,Chen X, Chen M, Xu X#. FunctionalCharacterization of a Novel Lipopolysaccharide-Binding Antimicrobial andAnti-Inflammatory Peptide in Vitro and in Vivo. J Med Chem. 2018,61(23):10709-10723
(28) HuangB, Li Y, Yao Y, Shu W#, Chen M#.Dihydromyricetin from ampelopsis grossedentata protects against vascularneointimal formation via induction of TR3. European Journal of Pharmacology. Eur J Pharmacol. 2018，838:23-31.（#通讯作者）
2017年
(27) Qin Q,Qin J, Chen M, Li Y, Meng T,Zhou J, Liang H#, Chen Z#. Chiral platinum (II)-4-(2,3-dihydroxypropyl)-formamide oxo-aporphine (FOA) complexes promote tumor cells apoptosis bydirectly targeting G-quadruplex DNA in vitro and in vivo. Oncotarget. 2017，8(37):61982-61997.
(26) Fan L, Luo J, Li X, ChenM, Shu W, Qu X#. Activation of Na+/H+ exchanger other than formation oftransmembrane pore underlies the cytotoxicity of nematocyst venom fromChrysaora helvola Brandt jellyfish. Toxicon.2017，133:162-168.
(25) HuangB., Yang F., Shu W., Chen Z., Chen M#.Functional roles of shear stress in vascular endothelial cells. Cell Immunol Serum Biol.2017,3(1):64-67 (#通讯作者)
2016年
(24) YangF., Shu W., Chen M#.Functional roles of protein arginine methyltransferase 5 in cardiovasculardiseases. J Cell Signal.2016,1: 123 (#通讯作者)
(23) Chen M#., Qu X., Zhang Z., WuH., Qin X., Li F., Liu Z., Tian L., Miao J.#, Shu W#. Crosstalk between Argmethylation and Ser phosphorylation modulates ASK1 activation in endothelialcells. Mol.Biol.Cell. 2016，27（8）：1358-1366（#通讯作者）
(22) Chen M., Yi B.,Zhu N., Wei X., Zhang G., Huang S., Sun J#. Pim1 kinase promotes angiogenesisthrough phosphorylation of endothelial nitric oxide synthase at Ser-633. Cardiovasc Res. 2016, 109(1):141-50
2015年以前
(21) Yan G., Zhu N., Huang S., Yi B., Shang X., Chen M., Wang N., Zhang G.,Talarico JA, Tilley DG., Gao E., Sun J#. Orphan Nuclear Receptor Nur77 InhibitsCardiac Hypertrophic Response to Beta-Adrenergic Stimulation. Mol Cell Biol. 2015,35(19):3312-23
(20) Qi J., Yang P., Yi B., Huo Y., ChenM., Zhang J., Sun J#. Heat shock protein 90 inhibition by 17-DMAGattenuates abdominal aortic aneurysm formation in mice. Am J Physiol Heart Circ Physiol. 2015, 308(8):H841-52.
(19) Chen M., Yi B., Sun J#. Inhibition of cardiomyocyte hypertrophy by proteinarginine methyltransferase 5. J. Biol.Chem. 2014, 289(35):24325-24335
(18) Qin Q. *, Chen M. *,Yi B., Li P., You X., Yang P., Sun J#. Orphan nuclear receptor Nur77 is a novelnegative regulator of ET-1 expression in vascular endothelial cells. Journal of Molecular and Cellular Cardiology.2014 (77):20-28 (*co-first author)
(17) Huo Y., Yi B., Chen M., Wan N., Guo C., Sun J#. Induction of Nur77 byhyperoside inhibits vascular smooth muscle cell proliferation and neointimal formation.Biochem Pharmacol. 2014, 92(4):590-8
(16) Liu Y., Zhang J., Yi B., ChenM., Qi J., Yin Y., Lu X., Jasmin J F., Sun J#. Nur77 suppressespulmonary artery smooth muscle cell proliferation through inhibition of theSTAT3/Pim-1/NFAT pathway. Am J RespirCell Mol Biol. 2014, 50(2):379-388
(15)Li P., Zhu N.,Yi B., Wang N., Chen M., You X., Zhao X., Qin Y., Sun J#.MicroRNA-663 regulates human vascular smooth muscle cell phenotypic switch andvascular neointimal formation. Circ Res. 2013, 113(10):11117-1127
(14) O-UchiJ., Jhun B, Hurst S., Bisseto S., Gross P., Chen M., KettlewellS., Park J., Oyamada H., Smith G.., Murayama T., Sheu S#. Over-expression ofryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-inducedATP production in cardiac H9c2 myoblasts. AJP-Heart and Circulatory Physiology.2013, 305(12):H1736-1751
(13) ZhouL., Ying W., Han Y., Chen M., Yan Y., Li L., Zhu Z., Zheng Z.,Jia W., Yang R.#, Qian X#. A proteome reference map and virulence factorsanalysis of Yersinia pestis 91001. J Proteomics. 2012, 75(3):894-907
(12) Chen M., Yang B., Ying W., He F., Qian X#. Annotation of non-synonymoussingle poly- morphisms in human liver proteome by mass spectrometry. ProteinPept Lett. 2010, 17(3):277-286
(11) WangX., Gong J., Liu X., Zhan R., Kong R., Zhao Y., Wan D., Leng X., Chen M.,#Qian L.# Expression of uncoupling protein3 in mitochondria protects againststress-induced myocardial injury: a proteomic study. Cell Stress Chaperones.2010, 15(6):771-779 （#通讯作者）
(10) JiangY.*, Ying W.*, Wu S.*, Chen M.*., Guan W., Yang D., Song Y., LiuX., Li J., Hao Y., Sun A., Geng C., Li H., Mi W., Zhang Y., Zhang J., Chen X.,Li L., Gong Y., Li T., Ma J., Li D., Yuan X., Zhang X., Xue X., Zhu Y., QianX.#, He F#., et al. First insight into human liver proteome fromPROTEOMESKY-LIVERHu 1.0, a publicly available database. J Proteome Res. 2010,9(1): 79-94 (*co-first author）
(9) ChenM.,# Wang Y., Zhao Y., Gong J., Yang Z., Qian L.# Dynamic proteomic andmetabolomic analysis reveal dysfunction and subclinical injury of rat liverduring restraint stress. Biochim Biophys Acta – Proteins & Proteomics.2009, 1794(12): 1751-1765 （#通讯作者）
(8) Chen M.#, Wang L., Gao X., Gong J., Qian X., Qian L. Effect of auxiliaryelectrospray on liquid chromatography–electrospray ionization-mass spectrometryanalysis. Journal of Chinese Mass Spectrometery Society. 2009, 30(6): 321-326
(7) ChenM., Ying W., Fang Q., Sun W., He F., Qian X#. The evaluation andapplication of a label-free quantitative proteomic strategy based onLC-ESI-MS/MS. Progress in Biochemistry and Biophysics. 2008, 35 (4): 401-409
(6) Sui S.,Wang J., Yang B., Song L., Zhang J., Chen M., Liu Ji., Lu Z., CaiY., Zhu Y., He F., Qian X#. Phosphoproteome analysis of human Chang liver cellby using SCX and a complementary mass spectrometric strategy. Proteomics. 2008,8(10): 2024-2034
(5) Wei J.,Zhang Y., Chen M., Qin P., Wang J., Cai Y., Qian X#. Effect ofdifferent experimental measures in nano-scale high performance liquidchromatography-electrospray tandem mass spectrometry on protein discovery rate.Journal of Chinese Mass Spectrometry Society. 2008, 29(4): 226-230
4) Chen M., Ying W., Song Y., Liu X., Yang Bi., Wu S., Jiang Y., Cai Y., He F.,Qian X#. Analysis of human liver proteome using replicate shotgun strategy.Proteomics. 2007, 7 (14): 2479-2488
3) Chen M., Ying W., Qian X#. Progress and challenge of large scale proteomeexpress profile. Chemistry of Life. 2007, 27(1): 17-20
(2) Chen M., Shen W.#, Ruan H., Xu L. Effects of nitric oxide on root growth andits oxidative damage in wheat seeding under salt stress. Journal of PlantPhysiology and Molecular Biology. 2004, 30(5): 569-576
(1) Chen M., Shen W#., Xu L. 14-3-3 Protein. Chemistry of Life. 2002, 22(5):445-448
