Prof. Dr. Zhen-Feng Chen
Tel: +86-773-2120998
Fax: +86-773-2120958
E-mail: chenzf@gxnu.edu.cn
Education
1998.09-2001.06 College of Chemistry and Chemical Engineering, Nanjing University,Ph.D.
1995.09-1998.06 Department of Chemistry and Chemical Engineering, Guangxi Normal University, Master
1989.09-1993.06 Department of Chemistry, Guangxi Teachers Education University
Professional Experience
2012.01-Current The Second Grade Professor, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China
2003.12-2012.12 Professor, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China
2001.07-2003.11 Associate Professor, Department Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, China
Honors and Awards
The Special Contribution Award of Guangxi Province Science and Technology Progress of China (Second Author), 2017
The Fixed Researcher in the State Key Laboratory, 2016
The Special Government Allowances of the State Council of China, 2016
The Second Prize of Guangxi Natural Science Award, 2016
Owner of Program for National Hundred, Thousand and Ten Thousand Talent of China, 2015
The National Young Experts with Outstanding Contributions of China, 2015
The Third Prize of Guangxi Natural Science Award, 2012
The Leader of Innovation Team of Ministry of Education, 2012
Bagui Scholar of Guangxi Province of China, 2011
The Eighth "Guangxi Youth Science and Technology Award", 2006
The Third Prize of Teaching Achievement Award at the Autonomous Region Level, 2005
Owner of Program for New Century Excellent Talents in University of Chinese Ministry of Education, 2004
The Second Level Owner of Program for New Century Ten, Hundred, Thousand Distinguished Talent of Guangxi of China, 2004
The First Grade Prize of Guangxi Province Science and Technology Progress (Second Author), 2003
One of the 100 Young and Middle-aged Disciplinary Leaders in Guangxi Province Higher Education Institutions of China, 2002
Outstanding Younger Teacher in Guangxi Normal University of China,2001
Main Research Grants
1. NNSF of China (81473102): Studies on the planar aromatic alkaloid-platinum complex small molecule ligands targeting the G-quadruplex and their antitumor, 600,000 Yuan; 2015.01-2018.12
2. NNSF of China (21271051): A series of highly active halo-substituted quinolinolato-lanthanide antitumor complexes regulated and controlled by estrogen targeting ligands, 780,000Yuan; 2013.01-2016.12
3. NNSF of China (20861002): Studies on the synthesis, structure and antitumor activity of the soluble metal complexes based on the effective component liriodenine from Guangxi special TCM zanthoxylum nitidum and shikimic acid from fructus anisi stellati, 270,000 Yuan; 2009.01-2011.12
4. NNSF of China (20361002): Studies on antitumor activity and metal complexes of benzo[c]phenanthridine alkaloids and indirubin ligands, 230,000 Yuan; 2004.01-2006.12
5. 973 Project from Ministry of Science and Technology of China (2009CB526503): The primary studies on the antitumor metal-based drugs basing on the active ingredient oxoaporphine alkaloids from the Traditional Chinese Medicines grown in Guangxi, 700,000 Yuan; 2009.04-2011.08
6. Project of Ministry of Education Innovation Team, China (IRT1225): Discovery, structural modification and function of the natural active substances, 4500,000 Yuan, 2013.01-2015.12
7. Project of Ministry of Education Innovation Team, China (IRT_16R15): Discovery, structural modification and function of the natural active substances, 3000,000 Yuan, 2017.01-2019.12
8. Project of NNSF Innovation Team of Guangxi, China (2016GXNSFGA380005): Discovery, structural modification and antitumor activity of the natural active compunds, 2000,000 Yuan, 2017.01-2019.12
9. Project of Bagui Scholar of Guangxi, China: Medicinal Chemistry, 5000,000 Yuan, 2012.01-2016.12
Representative Publications
1. Zhen-FengChen,* Qi-Pin Qin, Jiao-Lan Qin, Yan-Cheng Liu, Ke-Bin Huang, Yu-Lan Li,Ting Meng, Guo-Hai Zhang,Yan Peng, Xu-Jian Luo, Hong Liang*. Stabilization of G-quadruplex DNA, inhibition of telomerase activity, and tumor cell apoptosis by organoplatinum(II) complexes with oxoisoaporphine. J. Med. Chem., 2015, 58, 21592179.
2. Zhen-Feng Chen,* Qi-Pin Qin, Jiao-Lan Qin, Jie Zhou, Yu-Lan Li, Nan Li, Yan-Cheng Liu, Hong Liang*. Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): invitro and in vivo anticancer activity by stabilization of G-quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis. J. Med. Chem., 2015, 58, 47714789.
3. Ke-Bin Huang, Feng-Yang Wang, Xiao-Ming Tang, Hai-Wen Feng, Zhen-Feng Chen*, Yan-Cheng Liu, You-Nian Liu and Hong Liang*. Organometallic gold(III) complexes similar to tetrahydroisoquinoline (THIQ) induce ER-stress-mediated apoptosis and pro-death autophagy in A549 cancer cells. J. Med. Chem., 2018, 61, 34783490.
4. Qi-Pin Qin, Jiao-Lan Qin, Ting Meng, Wan-Hua Lin, Chuan-Hui Zhang, Zu-Zhuang Wei, Jia-Nian Chen, Yan-Cheng Liu, Hong Liang, Zhen-Feng Chen*. High in vivo antitumor activity of cobalt oxoisoaporphine complexes by targeting G-quadruplex DNA, telomerase and disrupting mitochondrial functions. Eur. J. Med. Chem., 2016, 124, 380−392.
5. Yan-Cheng Liu, Jian-Hua Wei, Zhen-Feng Chen*, Mei Liu, Yun-Qiong Gu, Ke-Bin Huang, Zhu-Quan Li and Hong Liang*. The antitumor activity of zinc(II) and copper(II) complexes with 5,7-dihalo-substituted-8-quinolinoline. Eur. J. Med. Chem., 2013, 69,554563.
6. Guohai Zhang, Yunfeng An, Xing Lu, Hui Zhong, Yanhong Zhu, Yiming Wu, Feng’e, Ma, Jingmei Yang, Yancheng Liu, Zuping Zhou, Yan Peng*, Zhenfeng Chen*. A novel naphthalimide compound restores p53 function in non–small–cell lung cancer by reorganizing the Bak–Bcl-xl complex and triggering transcriptional regulation. J. Biol. Chem., 2016, 291, 42114225.
7. Pei Liu, Jin-ling Liu, Heng-shan Wang,Ying-ming Pan*, Hong Liang, and Zhen-Feng Chen*. Copper-mediated crossing-coupling/cyclization/oxidation: One-pot to construct polysubstituted pyrroles. Chem. Commun. 2014, 50, 47954798.
8. Xu Wang, Shen-yan Li, Ying-ming Pan*, Heng-shan Wang, Hong Liang, Zhen-Feng Chen*, and Xiao-huan Qin. Samarium(III)-catalyzed C(sp3)–H bond activation: Synthesis of indolizines via C–C and C–N coupling between 2-alkylazaarenes and propargylic alcohols. Org. Lett., 2014, 16, 580583.
9. Pei Liu, Heng-shan Wang, Ying-ming Pan,* Wei-long Dai, Hong Liang and Zhen-Feng Chen*. The first palladium-catalyzed 1,4-addition of terminal alkenes to acrylate esters. Chem. Commoun., 2013, 49, 52955297.
10. Qi-Pin Qin, Jiao-Lan Qin, Ming Chen, Yu-Lan Li, Ting Meng, Jie Zhou, Hong Liang*, Zhen-Feng Chen*. Chiral platinum(II)-4-(2,3-Dihydroxypropyl)- formamide oxoaporphine (FOA) complexes promote tumor cells apoptosis by directly targeting G-quadruplex DNA in vitro and in vivo. Oncotarget, 2017, 8, 6198261997.
11. Jiao-Lan Qin†, Ting Meng†, Zhen-Feng Chen*, Xiao-Li Xie, Qi-Pin Qin, Xiao-Ju He, Ke-Bin Huang, Hong Liang*. Facile total synthesis of lysicamine and the anticancer activities of the RuII, RhIII, MnII and ZnII complexes of lysicamine. Oncotarget, 2017, 8, 5935959375.