Recent Publications
Articles
1. Ke-BinHuang, Feng-Yang Wang, Yuan Lu, Liang-Mei Yang, Nian Long, Shan-Shan Wang,Zhiying Xie, Matthew Levinec, Taotao Zou*, Jonathan L. Sessler*, Hong Liang*. Cu(II) complex thatsynergisticallypotentiates cytotoxicity and an antitumor immune response bytargeting cellularredox homeostasis. PNAS, 2024, 121(24), e2404668121.
2. XueyuMan , Wenjuan Li , Minghui Zhu , Shanhe Li , Gang Xu , Zhenlei Zhang , HongLiang*, Feng Yang*. Anticancer Tetranuclear Cu(I) Complex Catalyzes a ClickReaction to Synthesize a Chemotherapeutic Agent in situ to Achieve TargetedDual-Agent Combination Therapy for Cancer. Angew. Chem. Int. Ed., 2024 DOI: 10.1002/anie.202411846.
3. PeijingXu, Changchun Wen, Cunji Gao*, Huihui Liu, Yingshu Li, Xiaolu Guo, Xing-CanShen*, Hong Liang*. Near-Infrared-II-ActivatableSelf-Assembled ManganesePorphyrin-Gold Heterostructures for PhotoacousticImaging-GuidedSonodynamic-Augmented Photothermal/Photodynamic Therapy. ACS Nano, 2024, 18,713−727.
4. YuanLu, Shan-Shan Wang, Meng-Ya Li, Rong Liu, Meng-Fan Zhu, Liang-Mei Yang,Feng-Yang Wang, Ke-Bin Huang*, Hong Liang*. Cyclometalated iridium(III) complexbased on isoquinoline alkaloid synergistically elicits the ICD response and IDOinhibition via autophagy-dependent ferroptosis. Acta Pharm. Sin. B, 2024, DOI: 10.1016/j.apsb.2024.06.017.
5. YulongBai, Jing Hua, Jingjin Zhao*, Shulong Wang, Mengjiao Huang, Yang Wang, YanniLuo, Shulin Zhao*, Hong Liang*. A Silver-Induced Absorption Red-ShiftedDual-Targeted Nanodiagnosis-Treatment Agent for NIR-II PhotoacousticImaging-Guided Photothermal and ROS Simultaneously Enhanced Immune Checkpoint Blockade Antitumor Therapy. Adv. Sci., 2023, 2306375.
6. Qi-Yuan Yang+, Rui Ma+,Yun-Qiong Gu+, Xiao-Fang Xu, Zhen-Feng Chen*, Hong Liang*. Arene-Ruthenium(II)/Osmium(II) Complexes Potentiate the Anticancer Efficacy of Metformin via GlucoseMetabolism Reprogramming. Angew. Chem. Int. Ed., 2022, e202208570.
7. Xiaolin XiongⅡ, Ke-Bin HuangⅡ, Yuan WangⅡ, Bei Cao, Yunli Luo, Huowen Chen, Yan Yang, Yan Long, MoyiLiu, Albert S. C. Chan, Hong Liang*, Taotao Zou*. Target Profiling of anIridium(III)-Based Immunogenic Cell Death Inducer Unveils the Engagement of Unfolded Protein Response Regulator BiP. J. Am. Chem. Soc., 2022,144, 23, 10407–10416.
8. Yan-Lei Ma*, Ji-Ping Yue*, Yao Zhang*, Chen-Zhang Shi*,Matt Odenwald, Wenguang G. Liang, Qing Wei, Ajay Goel, Xue-Wen Gou, JamieZhang, Shao-Yu Chen, Wei-Jen Tang, Jerrold R. Turner, Feng Yang, Hong Liang*, Huan-Long Qin, Xiao-YangWu. ACF7 regulates inflammatory colitis and intestinal wound response byorchestrating tight junction dynamics. Nat. Commun. 2017,8, 15375.
9. Ji-Ping Yue, Yao Zhang, Wen-Guang G. Liang, Xue-Wen Gou,Philbert Lee, Han Liu, Wan-Qing Lyu, Wei-Jen Tang, Shao-Yu Chen, Feng Yang*, Hong Liang*, Xiao-Yang Wu*. InVivo Epidermal Migration Requires Focal Adhesion Targeting of ACF7. Nat.Commun. 2016, 7, 11692.
10. Yi Gou, GuoJin Huang , Jinlong Li, Feng Yang*, Hong Liang*. Versatile delivery systemsfor non-platinum metal-based anticancer therapeutic agents, Coordin.Chem. Rev., 2021, 441, 213975.
11. Wenjuan Li, Shanhe Li, Zhenlei Zhang, GangXu, Xueyu Man, Feng Yang*, Hong Liang*. Developing a Multitargeted AnticancerPalladium(II) Agent Based on the His-242 Residue in the IIA Subdomain of HumanSerum Albumin. J. Med. Chem., 2023, 66, 8564–8579.
12. XingLu, Mei-Feng Wu, Jiang-Lun Wu, Hai-Qun Zhang, HongLiang*, Zhen-Feng Chen*. Platinum-Based Mcl‑1 Inhibitor Targeting Mitochondria Achieves Enhanced Antitumor Activity asa Single Agent or in Combination withABT-199.J. Med. Chem., 2023, 66, 8705−8716.
13. ZhenleiZhang†, Juzheng Zhang†, Tongfu Yang†, Shanhe Li, Gang Xu, Hong Liang*,Feng Yang*. Developing an Anticancer Platinum(II) Compound Based on theUniqueness of Human Serum Albumin. J. Med. Chem., 2023,66，5669−5684.
14. XueyuMan§, Tongfu Yang§, Wenjuan Li, Shanhe Li, Gang Xu, Zhenlei Zhang, Hong Liang*,Feng Yang*. Developing a Gadolinium(III) Compound Based on Apoferritin forTargeted Magnetic Resonance Imaging and Dual-Modal Therapy of Cancer. J. Med. Chem., 2023,66, 7268−7279.
15. TongfuYang, Zhenlei Zhang, Juzheng Zhang, Yanping Li, Wenjuan Li, Hong Liang*,Feng Yang*. Developing a Gallium(III) Agent Based on the Properties of theTumor Microenvironment and Lactoferrin: Achieving Two-Agent Co-delivery andMulti-targeted Combination Therapy of Cancer. J. Med. Chem., 2023,66，793−803.
16. Shuang Kan, Rong Li, Yanhui Tan, Fang Yang, Shaohua Xu, Lingzhu Wang, Lijun Zhang, Xuchen Sun, Xuanming Chen, Yuting Yang, Wei Shu, Huaibin Wan, Zheng-Feng Chen, Hong Liang*, Ming Chen*. Latexin deficiency attenuates adipocyte differentiation and protects miceagainst obesity and metabolic disorders induced by high-fat diet. Cell Death & Disease,2022,13(2):175 .
17. Wen-Ying Shen, Chun-Peng Jia, Li-YiLiao,Liu-Lin Chen, Cheng Hou, Yang-Han Liu, Hong Liang*, Zhen-Feng Chen*. Copper(II) Complexes ofHalogenated Quinoline Schiff Base Derivatives Enabled Cancer Therapy throughGlutathione-Assisted Chemodynamic Therapy and Inhibition of Autophagy Flux. J. Med. Chem., 2022, 65,5134-5148.
18. Ming Jiang, Yong Chu, Tongfu Yang, WenjuanLi, Zhenlei Zhang, Hongbin Sun, HongLiang*, Feng Yang*. Developing a Novel Indium(III) AgentBased on Liposomes to Overcome Cisplatin-Induced Resistance in Breast Cancer byMultitargeting the Tumor Microenvironment Components. J. Med. Chem.,2021,64, 14587–14602.
19. ShulongWang, Jingjin Zhao, Liangliang Zhang*, Chaobang Zhang, Zhidong Qiu, Shulin Zhao*. Yong Huang, Hong Liang*. A Unique MultifunctionalNanoenzyme Tailored for Triggering Tumor Microenvironment Activated NIR-IIPhotoacoustic Imaging and Chemodynamic/Photothermal Combined Therapy. Adv. Healthcare Mater.,2021,2102073.
20. Juzheng Zhang, Ming Jiang, Shanhe Li, ZhenleiZhang, Hongbin Sun, Feng Yang*, Hong Liang*. Developing a NovelAnticancer Gold(III) Agent to Integrate Chemotherapy and Immunotherapy. J. Med. Chem., 2021, 64, 6777–6791.
21. Ju-Zheng Zhang, Zhen-Lei Zhang, MingJiang, Shan-He Li, Hao-Liang Yuan, Hong-Bin Sun, Feng Yang*, Hong Liang*. Developing a novelgold(III) agent to treat glioma based on the unique properties of apoferritinnanoparticles: inducing lethal autophagy and apoptosis，J. Med. Chem., 2020, 63, 13695–13708.
22. Noor Shad Gul†, Taj-MalookKhan1†, Yan-Cheng Liu, Muhammad Iqbal Choudhary, Zhen-Feng Chen*, HongLiang*. Pd(II) and Rh(III) Complexes with Isoquinoline DerivativesInduced Mitochondria-Mediated Apoptotic and Autophagic Cell Death in HepG2Cells, CCS Chem., 2020, 2, 1626–1641.
23. Xing Lu, Yan-Cheng Liu, Chris Orvig, HongLiang*, Zhen-Feng Chen*. Discovery of aCopper-Based Mcl‑1 Inhibitor as an Effffective Antitumor Agent, J. Med.Chem., 2020, 63, 9154–9167.
24. Zhen-Lei Zhang, Ping Yu, Yi Gou,Ju-Zheng Zhang, Shan-He Li, Mei-Ling Cai, Hong-Bin Sun, Feng Yang*, HongLiang*. A novel brain-tumor-inhibitingcopper(II) compound based on HSA–cell penetrating peptide conjugate. J. Med. Chem., 2019, 62, 10630–13069.
25. Ke-Bin Huang, Feng-Yang Wang, Xiao-Ming Tang, Hai-WenFeng, Zhen-Feng Chen*, Yan-Cheng Liu, You-Nian Liu, Hong Liang*. Organometallic Gold(III) Complexes Similar to TetrahydroisoquinolineInduce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 CancerCells.J. Med. Chem.,2018,61, 3478-3490.
26. Bang-Ping Jiang, Li Zhang, Xiao-Lu Guo,Xing-Can Shen*, Yan Wang, Yang Zhu,HongLiang*. Poly(N-phenylglycine)-Based Nanoparticles as HighlyEffective and Targeted Near-Infrared Photothermal Therapy/PhotodynamicTherapeutic Agents for Malignant Melanoma. Small,2017, 13, 1602496.
27. Zhen-FengChen*, Qi-Pin Qin, Jiao-Lan Qin, Jie Zhou, Yu-Lan Li, Nan Li, Yan-Cheng Liu, Hong Liang*.Water-soluble ruthenium(II) complexes with chiral4-(2,3-Dihydroxypropyl)-formamide oxoaporphine (FOA): in vitro and in vivoanticancer activity by stabilization of G-Quadruplex DNA, inhibition oftelomerase activity, and induction of tumor cell apoptosis. J. Med. Chem. 2015, 58, 4771–4789.
28. Zhen-FengChen*, Qi-Pin Qin, Jiao-Lan Qin, Yan-Cheng Liu, Ke-Bin Huang, Yu-Lan Li, TingMeng, Guo-Hai Zhang, Yan Peng, Xu-Jian Luo, Hong Liang*. Stabilization of G-quadruplex DNA, inhibition oftelomerase activity, and tumor cell apoptosis by organoplatinum(II) complexeswith oxoisoaporphine. J. Med. Chem.,2015, 58, 2159–2179.
29. Ming-HuaZeng*,Min-XiaYao, Hong Liang*, Wei-XiongZhang, Xiao-MingChen. A Single-Molecule-Magnetic, Cubane-Based, Triangular Co12Supercluster. Angew. Chem. Int. Ed., 2007, 46, 1832–1835.
30. Yi Gou*, Li Liu, Hong Liang*. Editorial on the Research Topic: The Developments of Metal-Based Agents Against Lung Cancer. Front Pharmacol., 2022,13, https://doi.org/10.3389/fphar.2022.1101890.
Editorial Articles
1. Editorial: Thedevelopments of metal-based agents against lung cancer, Frontiers in Pharmacology. Front. Pharmacol., 08 December 2022
2. HSA IIAsubdomain-based developing anticancer metal pro-drug: a new and improvedapproach. Future Med Chem., 2016, 8: 89-91.
3. HSA-based drug development and drug delivery systems. Curr PharmDesign., 2016, 21: 1784. (Medical Science SCI Division 2)
4. HSA-based anti-inflammatory therapy: a new and improved approach. FutureMed Chem., 2014, 6: 119-21. (Medical Science SCI Division 2)