Prof. Ke-Bin Huang, Ph.D.,
Education
2010.09-2013.06 NanKai University, Doctor
2007.09-2010.06 Guangxi Normal University, Master
2003.09-2007.06 Guangxi Normal University, Bachelor
Professional Experience
2018-2020 Visiting Scholar, Molecular and Cellular Oncology, M. D. Anderson Cancer Center, Houston, USA.
2016-Current Associate Professor, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China
2013-2015 Lecturer, School of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, China
Representative Publications
1. Ke-Bin Huang,Feng-Yang Wang,Xiao-Ming Tang,Hai-Wen Feng,Zhen-Feng Chen, Yan-Cheng Liu,You-Nian Liu, and Hong Liang. Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells, Journal of Medicinal Chemistry, 2018, 61, 3478 – 3490.
2. Feng-Yang Wang, Ke-Bin Huang⁎, Hai-Wen Feng, Zhen-Feng Chen, You-Nian Liu, Hong Liang.New Platinum(II) agent induces bimodal death of apoptosis and autophagy against A549 cancer cell,Free Radical Biology and Medicine, 2018, 129, 418–429.
3. Feng-Yang Wang, Xiao-Ming Tang, Xia Wang, Ke-Bin Huang⁎, Hai-Wen Feng, Zhen-Feng Chen, You-Nian Liu, Hong Liang,Mitochondria-targeted platinum(II) complexes induce apoptosis-dependent autophagic cell death mediated by ER-stress in A549 cancer cells, European Journal of Medicinal Chemistry, 2018, 155, 639 ~ 650.
4. Feng-Yang Wang, Qian-Yu Xi, Ke-Bin Huang*, Xiao-Ming Tang, Zhen-Feng Chen, Yan-Cheng Liu, Hong Liang⁎, Crystal structure, cytotoxicity and action mechanism of Zn (II)/Mn(II) complexes with isoquinoline ligands, Journal of Inorganic Biochemistry, 2017, 169,23 ~ 31.
5. Zhong-Yuan Mao, Xiao-Yun Liao, Heng-Shan Wang, Chun-Gu Wang, Ke-Bin Huang* and Ying-Ming Pan，Acid-catalyzed tandem reaction for the synthesis of pyridine derivatives via C]C/C(sp3)–N bond cleavage of enones and primary amines，RSC Advances,2017, 7, 13123–13129.
6. Hai-Rong Zhang, Ke-Bin Huang,* Zhen-Feng Chen,Yan-Cheng Liu, You-Nian Liu, Ting Meng, Qi-Pin Qin, Bi-Qun Zou and Hong Liang, Cobalt(II) 8-hydroxyquinoline complexes: structure, cytotoxicity, and action mechanism, MedChemComm, 2016, 7, 806-812.
7. Ke-Bin Huang, Hui-Yan Mo, Zhen-Feng Chen, Jian-Hua Wei, Yan-Cheng Liu, Hong Liang. Isoquinoline derivatives Zn(II)/Ni(II) complexes: Crystal structures, cytotoxicity, and their action mechanism. European Journal of Medicinal Chemistry, 2015, 100, 68 ~ 76.
8. Ke-Bin Huang, Zhen-Feng Chen, Yan-Cheng Liu, Xiao-Li Xie and Hong Liang, Dihydroisoquinoline copper(II) complexes: crystal structures, cytotoxicity, and action mechanism, RSC Advances, 2015, 5, 81313 ~ 81323.
9. Ke-Bin Huang, Zhen-Feng Chen, Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang, Guo-Hai Zhang, Hong Liang. Platinum(II) complexes with mono-aminophosphonate ester targeting group that induce apoptosis through G1 cell-cycle arrest: Synthesis, crystal structure and antitumour activity. European Journal of Medicinal Chemistry, 2013, 63, 76 ~ 84.
10. Ke-Bin Huang, Zhen-Feng Chen, Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang, Xiao-Li Xie, Hong Liang. Platinum(II) complexes containing aminophosphoate esters: synthsis, characterization, cytotoxicity and action mechanism. European Journal of Medicinal Chemistry, 2013, 64, 554 ~ 561.
11. Ke-Bin Huang, Zhen-Feng Chen, Yan-Cheng Liu, Meng Wang, Jian-Hua Wei, Xiao-Li Xie, Jian-Lian Zhang, Kun Hu, Hong Liang. Copper(II/I) complexes of 5-pyridin-2-yl-[1,3]dioxolo[4,5-g]isoquinoline Synthesis, crystal structure, antitumor activity and DNA interaction. European Journal of Medicinal Chemistry, 2013, 70, 640 ~ 648.