唐煌课题组

导师介绍

唐煌:博士,教授/研究员,主要从事合成药物化学领域的研究。内容包括抗阿尔茨海默氏症新型有机小分子化合物的设计合成以及生物活性评价研究。先后主持各类科研课题7项。其中,国家自然科学基金项目1项、广西自然科学基金项目3项,地厅级项目3项。以第一作者或通讯作者在Chem-Bio Inter, Eur. J. Med. Chem., Bioorg. Med. Chem. Lett.等国外学术刊物上发表科研论文十几篇。

教育背景:

(1) 2004.92007.12, 中山大学, 生物有机化学, 博士

(2) 1997.92000.7, 兰州大学, 有机合成, 硕士, 导师

(3) 1993.91997.7, 广西师范大学, 化学, 学士, 导师

工作经历:

2012.12-广西师范大学化学与药学学院,教授

2009.07-2012.11广西师范大学化学化工学院,副教授

2000.07-在广西师范大学化学与药学学院工作

代表性成果:

  1. Wang, J., Li, W., Qin, J., Wang, L., Wei, S., Tang, Huang*, Assessment of novel azaanthraquinone derivatives as potent multi-target inhibitors of inflammation and amyloid-beta aggregation in Alzheimer's disease. Bioorg. Chem.2019, 83, 477-486.

  2. Ke-Lin Chen; Ling Gan; Zhen-Hua Wu; Jin-Fang Qin; Wen-Xia Liao; Huang Tang*,4- Substituted sampangine derivatives: Novel acetylcholinesterase and β-myloid aggregation inhibitors , Int. J. Biol. Macromol. 2018, 107: 2725~2729.

  3. Zhenhua Wu ; Wenxia Liao; Kelin Chen; Jingfang Qin; Huang Tang*, Synthesis of derivatives of cleistopholine and their anti-acetylcholinesterase and anti-β-amyloid aggregation activity,Bioorg. Chem. 2018, 76: 228~236.

  4. Liyingzi Huang, Yunfeng Luo, Xianghui Kong, Huanhuan Xing, Zhijun Pu, Shenqi Wei, Wei Chen*, Huang Tang*, Oxoisoaporphine alkaloid derivative 8-1 reduces Aβ1-42 secretion and toxicity in human cell and Caenorhabditis elegans models of Alzheimer’s disease, Neurochem. Int.2017, 108: 157-168.

  5. Wei, Shenqi; Chen, Wei; Qin, Jingfang; Huangli, Yingzi; Wang, Li; Shen, Yue; Tang, Huang*, Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer’s disease. Bioorg. Med. Chem., 2016, 24(22): 6031-6039.

  6. Wei Chen, Yuhuan Wu, Shuming Zhong, Ling Cheng, Qinghua Li*, Huang Tang*. Anti-neurotoxicity effects of oxoisoaporphine-lipoic acid hybrids, Chemico-Biological Interactions 223 (2014) 45–50

  7. Tang, Huang; Zhao, H.-T.; Zhong, S.-M.; Wang, Z.-Y.; Chen, Z.-F.; Liang, H., Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Bioorg. Med. Chem. Lett. 2012, 22, (6), 2257-2261.

  8. Tang, Huang; Zhao, L.-Z.; Zhao, H.-T.; Huang, S.-L.; Zhong, S.-M.; Qin, J.-K.; Chen, Z.-F.; Huang, Z.-S.; Liang, H., Hybrids of oxoisoaporphine-tacrine congeners: Novel acetylcholinesterase and acetylcholinesterase-induced beta -amyloid aggregation inhibitors.Eur. J. Med. Chem.2011, 46, (10), 4970-4979.

  9. Tang, Huang; Wei, Y.-B.; Zhang, C.; Ning, F.-X.; Qiao, W.; Huang, S.-L.; Ma, L.; Huang, Z.-S.; Gu, L.-Q., Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase. Eur. J. Med. Chem. 2009, 44, (6), 2523-2532.

  10. Tang, Huang; Wang, X.-D.; Wei, Y.-B.; Huang, S.-L.; Huang, Z.-S.; Tan, J.-H.; An, L.-K.; Wu, J.-Y.; Sun-Chi Chan, A.; Gu, L.-Q., Oxoisoaporphine alkaloid derivatives: Synthesis, DNA binding affinity and cytotoxicity. Eur. J. Med. Chem.2008, 43, (5), 973-980.


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