Prof. Ming Chen, Ph.D.,

Dr. Chen Ming graduated from the Academy of Military Medical Sciences and completed postdoctoral training at Thomas Jefferson University. Dr. Chen joined the State Key Laboratory in 2016. He is currently a full professor and PI in the Laboratory of Cardiovascular Pharmacology. His research focused on cardiovascular pharmacology and disease proteomics. At present, more than 30 papers have been published in peer-reviewed academic journals.

Address: 15 Yucai Road, Qixing District, Guilin, 541004

E-mail: chenmingprotein@163.com

Research Interests:

１．Molecular mechanism of cardiovascular disease

(1) Regulation and remodeling of angiogenesis          

(2) Vascular injury and atherosclerosis

２．Inflammation and Immune Microenvironment Regulation      

３．Protein Chemistry and Proteomics         

(1) Function of protein complexes in cardiovascular diseases         

(2) Post-translational modification of proteins              

Education

2004/09-2007/07Academy of Military Medical Sciences, Beijing Proteomics Research Center，Ph.D.

2001/09-2004/07Nanjing Agricultural University, Department of Biochemistry and Molecular Biology, Master          

1997/09-2001/07Yangtze University，Department of Animal Science．Bachelor's degree

Professional Experience

2017.01－           Professor, Guangxi Normal University/College of Chemistry and Pharmacy         

2016.05-2016.12           Lijiang Scholar, Guangxi Normal University/College of Chemistry and Pharmacy          

2011/04-2015/10  Postdoctoral Fellow，Thomas Jefferson University/ Center for Translational Medicine           

2007/07-2011/01  Researcher，Academy of Military Medical Sciences/Institute of Health and Environmental Medicine

Honors and Awards

2019, Thousands of Key Teachers Selected for the Training Program，Guangxi         

2018, Winner of Guangxi Outstanding Youth Fund           

2016, Lijiang Scholar, Guangxi Normal University

Publications（2014-present）

2019年

(15) Huang B, Yao Y, Li Y, Yang H, Liu H, Liu H, Li D, Shu W, Chen M.Proteomics approach to investigate dynamic protein profile involved in high fat diet-induced fatty liver disease in rats. Journal of Toxicologic Pathology. [Advance publication] Released: July 05, 2019. https://doi.org/10.1293/tox.2018-0045（#通讯作者）

2018年

(14) Huang B, Li Y, Yao Y, Shu W#, Chen M#. Dihydromyricetin from ampelopsis grossedentata protects against vascular neointimal formation via induction of TR3. European Journal of Pharmacology. Eur J Pharmacol. 2018 Nov 5;838:23-31.（#通讯作者）

(13) Zeng B, Chai J, Deng Z, Ye T, Chen W, Li D, Chen X, Chen M, Xu X.Functional Characterization of a Novel Lipopolysaccharide-Binding Antimicrobial and Anti-Inflammatory Peptide in Vitro and in Vivo. J Med Chem. 2018 Nov 27. doi: 10.1021/acs.jmedchem.8b01358.

2017年

(12) Qin Q, Qin J, Chen M, Li Y, Meng T, Zhou J, Liang H#, Chen Z#. Chiral platinum (II)-4-(2,3-dihydroxypropyl)- formamide oxo-aporphine (FOA) complexes promote tumor cells apoptosis by directly targeting G-quadruplex DNA in vitro and in vivo. Oncotarget. 2017 Jun 28;8(37):61982-61997.

(11). Fan L, Luo J, Li X, Chen M, Shu W, Qu X#. Activation of Na+/H+ exchanger other than formation of transmembrane pore underlies the cytotoxicity of nematocyst venom from Chrysaora helvola Brandt jellyfish. Toxicon. 2017 Jul;133:162-168.

(10). Huang B., Yang F., Shu W., Chen Z., Chen M#. Functional roles of shear stress in vascular endothelial cells. Cell Immunol Serum Biol. 2017,3(1):64-67 (#通讯作者)

2016年

(9). Yang F., Shu W., Chen M#. Functional roles of protein arginine methyltransferase 5 in cardiovascular diseases. J Cell Signal. 2016,1: 123 (#通讯作者)

(8). Chen M#., Qu X., Zhang Z., Wu H., Qin X., Li F., Liu Z., Tian L., Miao J.#, Shu W#. Crosstalk between Arg methylation and Ser phosphorylation modulates ASK1 activation in endothelial cells. Mol.Biol.Cell. 2016，27（8）： 1358-1366（#通讯作者）

(7). Chen M., Yi B., Zhu N., Wei X., Zhang G., Huang S., Sun J#. Pim1 kinase promotes angiogenesis through phosphorylation of endothelial nitric oxide synthase at Ser-633. Cardiovasc Res. 2016, 109(1):141-50

2015年

(6). Yan G., Zhu N., Huang S., Yi B., Shang X., Chen M., Wang N., Zhang G., Talarico JA, Tilley DG., Gao E., Sun J#. Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation. Mol Cell Biol. 2015, 35(19):3312-23

(5). Qi J., Yang P., Yi B., Huo Y., Chen M., Zhang J., Sun J#. Heat shock protein 90 inhibition by 17-DMAG attenuates abdominal aortic aneurysm formation in mice. Am J Physiol Heart Circ Physiol. 2015, 308(8):H841-52

2014年

(4). Chen M., Yi B., Sun J#. Inhibition of cardiomyocyte hypertrophy by protein arginine methyltransferase 5. J. Biol. Chem. 2014, 289(35):24325-24335

(3). Qin Q. *, Chen M. *, Yi B., Li P., You X., Yang P., Sun J#. Orphan nuclear receptor Nur77 is a novel negative regulator of ET-1 expression in vascular endothelial cells. Journal of Molecular and Cellular Cardiology. 2014 (77):20-28 (*co-first author)

(2). Huo Y., Yi B., Chen M., Wan N., Guo C., Sun J#. Induction of Nur77 by hyperoside inhibits vascular smooth muscle cell proliferation and neointimal formation. Biochem Pharmacol. 2014, 92(4):590-8

(1). Liu Y., Zhang J., Yi B., Chen M., Qi J., Yin Y., Lu X., Jasmin J F., Sun J#. Nur77 suppresses pulmonary artery smooth muscle cell proliferation through inhibition of the STAT3/Pim-1/NFAT pathway. Am J Respir Cell Mol Biol. 2014, 50(2):379-388