datetime： 2018-11-23 views： 1419
Prof. Zhen-Feng Chen, Ph.D.,
Dr. Chen received his Ph.D in 2001 in Nanjing University, China. He is the supervisor for Ph. D and Master Degree Program of Medicinal Chemistry and Inorganic Chemistry. He takes delight in collaborating with the international medicinal chemists. He is happy to accept foreign Ph. D students in medicinal chemistry. Now he focused on the research on metal medicinal chemistry of active ingredients of traditional Chinese medicine (TCM). He raised the idea of designing metallic drugs by coordinating and regulating effects of TCM active ingredients and metallic active centers, and a series of metal anti-tumor lead compounds with multiple targets and multiple mechanisms of action have been obtained.
Education
1998.09-2001.06 College of Chemistry and Chemical Engineering, Nanjing University,Ph.D.
1995.09-1998.06 Department of Chemistry and Chemical Engineering, Guangxi Normal University, Master
1989.09-1993.06 Department of Chemistry, Guangxi Teachers Education University
Professional Experience
2012.01-Current The Second Grade Professor, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China
2003.12-2012.12 Professor, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China
2006-2007 Visiting professor work with Prof. Chris Orvig in British Columbia Univeristy, Canada
2001.07-2003.11 Associate Professor, Department Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, China
Honors and Awards
The Special Contribution Award of Guangxi Province Science and Technology Progress of China (Second Author), 2017
The Fixed Researcher in the State Key Laboratory, 2016
The Special Government Allowances of the State Council of China, 2016
The Second Prize of Guangxi Natural Science Award, 2016
Owner of Program for National Hundred, Thousand and Ten Thousand Talent of China, 2015
The National Young Experts with Outstanding Contributions of China, 2015
The Third Prize of Guangxi Natural Science Award, 2012
The Leader of Innovation Team of Ministry of Education, 2012
Bagui Scholar of Guangxi Province of China, 2011
The Eighth Guangxi Youth Science and Technology Award, 2006
The Third Prize of Teaching Achievement Award at the Autonomous Region Level, 2005
Owner of Program for New Century Excellent Talents in University of Chinese Ministry of Education, 2004
The Second Level Owner of Program for New Century Ten, Hundred, Thousand Distinguished Talent of Guangxi of China, 2004
The First Grade Prize of Guangxi Province Science and Technology Progress (Second Author), 2003
One of the 100 Young and Middle-aged Disciplinary Leaders in Guangxi Province Higher Education Institutions of China, 2002
Outstanding Younger Teacher in Guangxi Normal University of China,2001
Main Research Grants
1. NNSF of China (81473102): Studies on the planar aromatic alkaloid-platinum complex small molecule ligands targeting the G-quadruplex and their antitumor, 600,000 Yuan; 2015.01-2018.12
2. NNSF of China (21271051): A series of highly active halo-substituted quinolinolato-lanthanide antitumor complexes regulated and controlled by estrogen targeting ligands, 780,000Yuan; 2013.01-2016.12
3. NNSF of China (20861002): Studies on the synthesis, structure and antitumor activity of the soluble metal complexes based on the effective component liriodenine from Guangxi special TCM zanthoxylum nitidum and shikimic acid from fructus anisi stellati, 270,000 Yuan; 2009.01-2011.12
4. NNSF of China (20361002): Studies on antitumor activity and metal complexes of benzo[c]phenanthridine alkaloids and indirubin ligands, 230,000 Yuan; 2004.01-2006.12
5. 973 Project from Ministry of Science and Technology of China (2009CB526503): The primary studies on the antitumor metal-based drugs basing on the active ingredient oxoaporphine alkaloids from the Traditional Chinese Medicines grown in Guangxi, 700,000 Yuan; 2009.04-2011.08
6. Project of Ministry of Education Innovation Team, China (IRT1225): Discovery, structural modification and function of the natural active substances, 4500,000 Yuan, 2013.01-2015.12
7. Project of Ministry of Education Innovation Team, China (IRT_16R15): Discovery, structural modification and function of the natural active substances, 3000,000 Yuan, 2017.01-2019.12
8. Project of NNSF Innovation Team of Guangxi, China (2016GXNSFGA380005): Discovery, structural modification and antitumor activity of the natural active compunds, 2000,000 Yuan, 2017.01-2019.12
9. Project of Bagui Scholar of Guangxi, China: Medicinal Chemistry, 5000,000 Yuan, 2012.01-2016.12
Representative Publications
1. Ke-Bin Huang, Feng-Yang Wang, Xiao-Ming Tang, Hai-Wen Feng, Zhen-Feng Chen*, Yan-Cheng Liu, You-Nian Liu and Hong Liang*. Organometallic gold(III) complexes similar to tetrahydroisoquinoline(THIQ) induce ER-stress-mediated apoptosis and pro-death autophagyin A549 cancer cells. J. Med. Chem., 2018, 61, 3478-3490.
2. Zhen-FengChen,* Qi-Pin Qin, Jiao-Lan Qin, Yan-Cheng Liu, Ke-Bin Huang, Yu-Lan Li,Ting Meng, Guo-Hai Zhang,Yan Peng, Xu-Jian Luo, Hong Liang*. Stabilization of G-quadruplex DNA, inhibition of telomerase activity, and tumor cell apoptosis by organoplatinum(II) complexes with oxoisoaporphine. J. Med. Chem., 2015, 58, 2159-2179.
3. Zhen-Feng Chen,* Qi-Pin Qin, Jiao-Lan Qin, Jie Zhou, Yu-Lan Li, Nan Li, Yan-Cheng Liu, Hong Liang*. Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): invitro and in vivo anticancer activity by stabilization of G-quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis. J. Med. Chem., 2015, 58, 4771-4789.
4. Yan-Cheng Liu, Zhen-Feng Chen*, Xiao-Yan Song, Yan Peng, Qi-Pin Qin, Hong Liang*. Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dibromo-8-quinolinolato- lanthanides. Eur. J. Med. Chem., 2013, 59, 168-175.
5. Zhen-Feng Chen*, Yun-Qiong Gu, Xiao-Yan Song, Yan-Cheng Liu, Yan Peng, Hong Liang*. Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dichloro-8- quinolinolato-lanthanides. Eur. J. Med. Chem., 2013, 59, 194-202.
6. Zhen-Feng Chen*, Yan Peng, Yun-Qiong Gu, Yan-Cheng Liu, Mei Liu, Ke-Bin Huang, Kun Hu and Hong Liang*. High antitumor activity of 5,7-dihalo-8- quinolinolato tin(IV) complexes. Eur. J. Med. Chem., 2013, 62,51-58.
7. Ke-Bin Huang, Zhen-Feng Chen*, Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang， Guo-Hai Zhang, Hong Liang*. Platinum(II) complexes with mono-aminopho- sphonate ester targeting group that induce apoptosis through G1 cell-cycle arrest: Synthesis, crystal structure and antitumour activity. Eur. J. Med. Chem., 2013, 63, 76-84.
8. Ke-Bin Huang, Zhen-Feng Chen,* Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang, Xiao-Li Xie, and Hong Liang*. Platinum(II) complexes containing aminophosphonate esters: synthsis, characterization, cytotoxicity and action mechanism. Eur. J. Med. Chem., 2013, 64, 554-561.
9. Zhen-Feng Chen,* Jian-Hua Wei, Yan-Cheng Liu, Mei Liu, Yun-Qiong Gu, Ke-Bin Huang, Meng Wang, Hong Liang*. High antitumor activity of 5,7-dihalo-8-quinolinolato cerium complexes. Eur. J. Med. Chem., 2013, 68, 454-462.
10. Yan-Cheng Liu, Jian-Hua Wei, Zhen-Feng Chen*, Mei Liu, Yun-Qiong Gu, Ke-Bin Huang, Zhu-Quan Li and Hong Liang*. The antitumor activity of zinc(II) and copper(II) complexes with 5,7-dihalo-substituted-8-quinolinoline. Eur. J. Med. Chem., 2013, 69,554-563.
11. Ke-Bin Huang, Zhen-Feng Chen*, Yan-Cheng Liu, Meng Wang, Jian-Hua Wei, Xiao-Li Xie, Jian-Lian Zhang, Kun Hu, Hong Liang*. Copper(II/I) complexes of 5-pyridin-2-yl-[1,3] dioxolo[4,5-g]isoquinoline: synthesis, crystal structure, antitumor activity and DNA interaction. Eur. J. Med. Chem., 2013, 70, 640-648.
12. Qi-Pin Qin, Zhen-Feng Chen*, Wen-Ying Shen, Yan-Hua Jiang, Dong Cao, Yu-Lan Li, Qing-Min Xu, Yan-Cheng Liu, Ke-Bin Huang, Hong Liang*. Synthesis of a platinum(II) complex with 2-(4-methoxy-phenyl)imidazo [4,5-f]-[1,10] phenanthrolin and study of its antitumor activity. Eur. J. Med. Chem., 2015, 89, 77-87.
13. Qi-Pin Qin, Zhen-Feng Chen*, Jiao-Lan Qin, Xiao-Ju He, Yu-Lan Li, Yan-Cheng Liu, Ke-Bin Huang and Hong Liang*. Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: synthesis, characterization, cytotoxicity, cell cycle and apoptosis. Eur. J. Med. Chem., 2015, 92, 302-313.
14. Qi-Pin Qin, Jiao-Lan Qin, Ting Meng, Wan-Hua Lin, Chuan-Hui Zhang, Zu-Zhuang Wei, Jia-Nian Chen, Yan-Cheng Liu, Hong Liang, Zhen-Feng Chen*. High in vivo antitumor activity of cobalt oxoisoaporphine complexes by targeting G-quadruplex DNA, telomerase and disrupting mitochondrial functions. Eur. J. Med. Chem., 2016, 124, 380−392.
15. Yan-Cheng Liu, Jian-Hua Wei, Zhen-Feng Chen*, Mei Liu, Yun-Qiong Gu, Ke-Bin Huang, Zhu-Quan Li and Hong Liang*. The antitumor activity of zinc(II) and copper(II) complexes with 5,7-dihalo-substituted-8-quinolinoline. Eur. J. Med. Chem., 2013, 69,554-563.
16. Zu-Zhuang Wei(#), Qi-Pin Qin(#), Ting Meng, Cai-Xing Deng, Hong Liang, Zhen-Feng Chen*. 5-Bromo-oxoisoaporphine platinum(II) complexes exhibit tumor cell cytotoxcicity via inhibition of telomerase activity and disruption of c-myc G-quadruplex DNA and mitochondrial functions. Eur. J. Med. Chem., 2018, 145, 360-369.
17. Wen-Bin Kuang, Ri-Zhen Huang, Jiao-Lan Qin, Xing Lu, Qi-Pin Qin, Bi-Qun Zou, Zhen-Feng Chen,**, Hong Liang,***, Ye Zhang*. Design, synthesis and pharmacological evaluation of new 3-(1Hbenzimidazol-2-yl)quinolin-2(1H)-one derivatives as potential antitumor agents. Eur. J. Med. Chem., 2018, 157, 139-150.
18. Taj-Malook Khan, Noor Shad Gul, Xing Lu, Jian-Hua Wei, Yan-Cheng Liu, Hongbin Sun*, Hong Liang***, Chris Orvig, Zhen-Feng Chen**. In vitro and in vivo anti-tumor activity of two gold(III) complexes with isoquinoline derivatives as ligands. Eur. J. Med. Chem., 2019, 163, 333-342.
19. Bao-Li Fei*, Shuangyan Tu, Zuzhuang Wei, Pingping Wang, Chunhua Qiao ***, Zhen-Feng Chen**. Optically pure chiral copper(II) complexes of rosin derivative as attractive anticancer agents with potential anti-metastatic and anti-angiogenic activities. Eur. J. Med. Chem., 2019, 176, 175-186.
20. Xing Lu, Yan-Cheng Liu, Chris Orvig, Hong Liang **, Zhen-Feng Chen*. Discovery of b-carboline copper(II) complexes as Mcl-1 inhibitor and in vitro and in vivo activity in cancer models. Eur. J. Med. Chem., 2019, 181, 111567.
21. Zhen-Feng Chen*, Chris Orvig and Hong Liang*. Multi-target metal-based anticancer agents. Current Topics in Medicinal Chemistry, 2017,17, 1331-1345.
22. Zhen-Feng Chen*, Yan-Cheng Liu, Ke-Bin Huang and Hong Liang*. Alkaloid-metal based anticancer agents. Current Topics in Medicinal Chemistry, 2013, 13, 2104-2115.
23. Zhen-Feng Chen*, Yan-Fang Shi, Yan-Cheng Liu, Xue Hong, Bo Geng, Yan Peng, Hong Liang*, TCM active ingredient oxoglaucine metal complexes: Crystal structure, cytotoxicity and interaction with DNA. Inorganic Chemistry, 2012, 51, 1998-2009.
24. Bao-Li Fei*, Shuangyan Tu, Zuzhuang Wei, Pingping Wang, Jian-Ying Long, Chunhua Qiao* and Zhen-Feng Chen*. Biological evaluation of optically pure chiral binuclear copper(II) complexes based on rosin derivative as highly potential anticancer agents. Dalton Trans., 2019, DOI: 10.1039/C9DT01942A.
25. Taj-Malook Khan, Noor Shad Gul, Xing Lu, Rajesh Kumar, Muhammad Iqbal Choudhary,b Hong Liang* and Zhen-Feng Chen*. Rhodium(III) complexes with isoquinoline derivatives as potential anticancer agents: in vitro and in vivo activity studies. Dalton Trans., 2019, 48,11469-11479.
26. Qi-Pin Qin, Jiao-Lan Qin, Ming Chen, Yu-Lan Li, Ting Meng, Jie Zhou, Hong Liang*, Zhen-Feng Chen*. Chiral platinum(II)-4-(2,3-Dihydroxypropyl)- formamide oxoaporphine (FOA) complexes promote tumor cells apoptosis by directly targeting G-quadruplex DNA in vitro and in vivo. Oncotarget, 2017, 8, 61982-61997.
27. Jiao-Lan Qin†, Ting Meng†, Zhen-Feng Chen*, Xiao-Li Xie, Qi-Pin Qin, Xiao-Ju He, Ke-Bin Huang, Hong Liang*. Facile total synthesis of lysicamine and the anticancer activities of the RuII, RhIII, MnII and ZnII complexes of lysicamine. Oncotarget, 2017, 8, 59359-59375.
28. Jiao-Lan Qin(#), Wen-Ying Shen(#), Zhen-Feng Chen*, Li-Fang Zhao, Qi-Pin Qin, Yan-Cheng Yu & Hong Liang*. Oxoaporphine metal complexes (CoII, NiII, ZnII) with high antitumor activity by inducing mitochondria-mediated apoptosis and S-phase arrest in HepG2. Scientific Reports, 2017, 7:46056.
29. Qi-Pin Qin(#), Jiao-Lan Qin(#), Ting Meng, Gui-Ai Yang, Zu-Zhuang Wei, Yan-Cheng Liu, Hong Liang* & Zhen-Feng Chen*. Preparation of 6/8/11-amino/chloro-oxoisoaporphine and group-10 metal complexes and evaluation of their in vitro and in vivo antitumor activity. Scientific Reports, 2016, 6: 37644.
30. Guohai Zhang, Yunfeng An, Xing Lu, Hui Zhong, Yanhong Zhu, Yiming Wu, Feng’e, Ma, Jingmei Yang, Yancheng Liu, Zuping Zhou, Yan Peng*, Zhenfeng Chen*. A novel naphthalimide compound restores p53 function in non–small–cell lung cancer by reorganizing the Bak–Bcl-xl complex and triggering transcriptional regulation. J. Biol. Chem., 2016, 291, 4211-4225.
31. Guo-Hai Zhang#, Le-Jing Cai#, Yan-Fei Wang, Yuan-Hua Zhou, Yun-Feng An, Yan-Cheng Liu, Yan Peng*, Zhen-Feng Chen*, Hong Liang*. Novel compound PS-101 exhibits selective inhibition in non–small-cell lung cancer cell by blocking the EGFR-driven antiapoptotic pathway. Biochemical Pharmacology, 2013, 86, 1721-1730.
32. Zu-Yu Mo, Toreshettahally R. Swaroop, Wei Tong, Yu-Zhen Zhang,Hai-Tao Tang,* Ying-Ming Pan,* Hong-Bin Sun and Zhen-Feng Chen*. Electrochemical sulfonylation of thiols with sulfonyl hydrazides: a metal- and oxidant-free protocol for the synthesis of thiosulfonates. Green Chemistry, 2018, 20(19), 4428-4432.32.
33. Pei Liu, Jin-ling Liu, Heng-shan Wang,Ying-ming Pan*, Hong Liang, and Zhen-Feng Chen*. Copper-mediated crossing-coupling/cyclization/oxidation: One-pot to construct polysubstitutedpyrroles. Chem. Commun. 2014, 50, 4795-4798.
34. Pei Liu, Heng-shan Wang, Ying-ming Pan,* Wei-long Dai, Hong Liang and Zhen-Feng Chen*. The first palladium-catalyzed 1,4-addition of terminal alkenes to acrylate esters. Chem. Commoun., 2013, 49, 5295-5297.
35. Xu Wang, Shen-yan Li, Ying-ming Pan*, Heng-shan Wang, Hong Liang, Zhen-Feng Chen*, and Xiao-huan Qin. Samarium(III)-catalyzed C(sp3)–H bond activation: Synthesis of indolizines via C–C and C–N coupling between 2-alkylazaarenes and propargylic alcohols. Org. Lett., 2014, 16, 580-583.