Hong Liang, Professor

Tel: + 86- (0)773- 2565678/+ 86- (0)773- 3560088

E-mail: hliang@mailbox.gxnu.edu.cn

Prof. Dr. Hong Liang is currently the vice chairman of Guangxi Association for Science and Technology, director of the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education, and a supervisor for Ph. D program in Guangxi Normal University. He served as the president of Guangxi Normal University from Jan. 2002 to July 2017.

In scientificresearch, he has sofar ledmorethan 30 projects and programs, including one Key National Natural Science Fund Project, three 973 pre-special programs,and seven National Natural Science Fund Projects. Among about 500 papers he published in the SCIkey journals like Nat. Commun., JACS, Angew. Chem.. Int. Ed.,Coord. Chem.Rev.,J. Med. Chem., Small, Chem. Comm., Eur. Chem. J., Eur. J. Med. Chem.,Inorg. Chem., Anal. Chem., J. Inorg. Biochem., Mol. Pharm., and his papers havebeen cited for over 10672 times in SCI journals, and H-index is 51.Furthermore, he has possessed more than 60 authorized invention patents inChina. For his outstanding academic achievements, he was awarded quite a few prizesand honorary titles, such as, Fellow of Royal Society of Chemistry(FRSC),Editorial Board Member for Journal of Inorganic Biochemistry(JIB) , Journal ofNatural Medicines Research(JNMR), and so on.

Research Interests

1. Pharmacological effects of active components of traditional chinese medicine in metal-based anti-tumor drugs

2. Novel metal-based anti-tumor drugs and drug delivery system of protein

1）Mechanism of cell migration

2）DNA and Protein based design of novel metal-based anti-tumor drugs

3）Protein nanoparticle drug delivery system

3. Integration of diagnosis and treatment of nanoparticle materials

4. New method of real-time in-situ monitoring of life process

Social service

1. Fellow of Royal Society of Chemistry, UK

2. Director of Chinese Chemistry Association

3. Member of Inorganic Chemistry Committee of Chinese chemistry Association

4. Member of Applied Chemistry Committee of Chinese Chemistry Association

5. Honorary director of Chemistry and Chemical Industry Society of Guangxi

6. Guest editor for Current Pharmaceutical Design

7. Member of editorial board for Journal of Inorganic Biochemistry, Chinese Journal of Inorganic Chemistry, Journal of Chemistry Education, Journal of NaturalMedicines Research

Course

Bioinorganic Chemistry

Recent Publications and Patents

Articles

1. Qi-Yuan Yang+, Rui Ma+,Yun-Qiong Gu+, Xiao-Fang Xu, Zhen-FengChen*, Hong Liang*. Arene-Ruthenium(II)/Osmium(II)Complexes Potentiate theAnticancer Efficacy of Metformin via GlucoseMetabolism Reprogramming.Angew. Chem. Int. Ed., 2022, e202208570

2. Xiaolin XiongⅡ, Ke-BinHuangⅡ, YuanWangⅡ, BeiCao, Yunli Luo, Huowen Chen, Yan Yang, YanLong, MoyiLiu, Albert S. C. Chan, HongLiang*, Taotao Zou*，Target Profiling of an Iridium(III)-Based ImmunogenicCell DeathInducer Unveils the Engagement of Unfolded Protein ResponseRegulator BiP. J.Am. Chem. Soc., 2022, 144, 23, 10407–10416

3. Shuang Kan, Rong Li, Yanhui Tan, FangYang, Shaohua Xu, Lingzhu Wang, Lijun Zhang, XuchenSun, Xuanming Chen,Yuting Yang, Wei Shu, Huaibin Wan, Zheng-FengChen, Hong Liang*, Ming Chen*. Latexin deficiency attenuates adipocytedifferentiation and protects miceagainst obesity and metabolic disordersinduced by high-fat diet. Cell Death & Disease,2022,13(2):175

4. Wen-Ying Shen, Chun-Peng Jia, Li-YiLiao,Liu-Lin Chen, ChengHou, Yang-Han Liu, Hong Liang*, Zhen-Feng Chen*. Copper(II) ComplexesofHalogenated Quinoline Schiff Base Derivatives Enabled Cancer TherapythroughGlutathione-Assisted Chemodynamic Therapy and Inhibition of AutophagyFlux.  J. Med. Chem., 2022, 65,5134-5148

5. Ming Jiang, Yong Chu, Tongfu Yang, WenjuanLi, ZhenleiZhang, Hongbin Sun, HongLiang*, Feng Yang*. Developing a Novel Indium(III)AgentBased on Liposomes to Overcome Cisplatin-Induced Resistance in BreastCancer byMultitargeting the Tumor Microenvironment Components. J. Med.Chem.,2021,64, 14587–14602

6. Shulong Wang, Jingjin Zhao, LiangliangZhang*, Chaobang Zhang,Zhidong Qiu, Shulin Zhao*. Yong Huang, Hong Liang*.A Unique MultifunctionalNanoenzyme Tailored for Triggering TumorMicroenvironment Activated NIR-IIPhotoacoustic Imaging andChemodynamic/Photothermal Combined Therapy. Adv.Healthcare Mater.2021,2102073

7. Yi Gou, GuoJin Huang , Jinlong Li, FengYang*, Hong Liang*.Versatile delivery systems for non-platinum metal-basedanticancer therapeuticagents, Coordin. Chem. Rev., 2021, 441, 213975

8. Juzheng Zhang, Ming Jiang, Shanhe Li, ZhenleiZhang, HongbinSun, Feng Yang*, Hong Liang*. Developing a NovelAnticancer Gold(III) Agent toIntegrate Chemotherapy and Immunotherapy. J. Med. Chem., 2021, 64, 6777–6791

9. Ju-Zheng Zhang, Zhen-Lei Zhang, MingJiang, Shan-He Li,Hao-Liang Yuan, Hong-Bin Sun, Feng Yang*, Hong Liang*. Developing anovelgold(III) agent to treat glioma based on the unique properties ofapoferritinnanoparticles: inducing lethal autophagy and apoptosis，J. Med. Chem., 2020, 63, 13695–13708

10. Noor Shad Gul†, Taj-MalookKhan1†, Yan-Cheng Liu, MuhammadIqbal Choudhary, Zhen-Feng Chen*, HongLiang*. Pd(II) and Rh(III) Complexes withIsoquinoline DerivativesInduced Mitochondria-Mediated Apoptotic and AutophagicCell Death in HepG2Cells, CCS Chem., 2020, 2, 1626–1641

11. Xing Lu, Yan-Cheng Liu, Chris Orvig, HongLiang*, Zhen-FengChen*. Discovery of aCopper-Based Mcl‑1 Inhibitor as an Effffective AntitumorAgent, J. Med.Chem., 2020, 63, 9154–9167

12. JiayaoXu, Lina Fang, Ming Shi, Yong Huang*, LifangYao, Shulin Zhao*, LiangliangZhang, HongLiang*. Apeptide-based four-colorfluorescent polydopamine nanoprobe for multiplexedsensing and imaging ofproteases in living cells. Chem. Commun., 2019,55, 1651–1654

13. Zhen-Lei Zhang, Ping Yu, Yi Gou,Ju-Zheng Zhang, Shan-He Li,Mei-Ling Cai, Hong-Bin Sun, Feng Yang*, HongLiang*. A novel brain-tumor-inhibitingcopper(II)compound based on HSA–cell penetrating peptide conjugate. J. Med. Chem., 2019,62, 10630–13069

14. Ke-Bin Huang, Feng-Yang Wang, Hai-WenFeng, He-Jiang Luo, YanLong, Tao-Tao Zou*, Albert S.C.Chan, Rong Liu,Hua-Hong Zou, Zhen-Feng Chen*,Yan-Cheng Liu, You-Nian Liu, Hong Liang*. An aminophosphonateesterligand-containing platinum(ii) complex induces potent immunogenic celldeathinvitro and elicits effectiveanti-tumour immune responses in vivo. Chem. Commun.,2019, 55, 13066

15. Feng-Yang Wang, Ke-Bin Huang*, Hai-WenFeng, Zhen-Feng Chen,You-Nian Liu, HongLiang*. New Platinum (II) agent induces bimodal death ofapoptosis andautophagy against A549 cancer cell. Free Radical Bio. Med., 2018,129,418–429

16. Ke-Bin Huang, Feng-Yang Wang, Xiao-Ming Tang, Hai-WenFeng,Zhen-Feng Chen*, Yan-Cheng Liu, You-Nian Liu, Hong Liang*. OrganometallicGold(III) Complexes Similar to TetrahydroisoquinolineInduce ER-Stress-MediatedApoptosis and Pro-Death Autophagy in A549 CancerCells.J. Med. Chem.,2018,61,3478-3490

17. Bang-Ping Jiang, Li Zhang, Xiao-Lu Guo,Xing-Can Shen*, YanWang, Yang Zhu, HongLiang*. Poly(N-phenylglycine)-Based Nanoparticles asHighlyEffective and Targeted Near-Infrared Photothermal Therapy/PhotodynamicTherapeuticAgents for Malignant Melanoma. Small,2017,13, 1602496

18. Yan-Lei Ma, Ji-Ping Yue, Yao Zhang, Chen-Zhang Shi, MattOdenwald,Wenguang G. Liang, Qing Wei, Ajay Goel, Xue-Wen Gou, Jamie Zhang,Shao-Yu Chen,Wei-Jen Tang, Jerrold R. Turner, Feng Yang*, HongLiang*, Huan-LongQin*, Xiao-Yang Wu*. ACF7 regulates inflammatory colitis and intestinalwoundresponse by orchestrating tight junction dynamics. Nat.Commun. 2017,8, 15375

19. Ji-Ping Yue, Yao Zhang, Wen-Guang G. Liang, Xue-WenGou,Philbert Lee, Han Liu, Wan-Qing Lyu, Wei-Jen Tang, Shao-Yu Chen, FengYang*, Hong Liang*, Xiao-Yang Wu*. InVivo Epidermal MigrationRequires Focal Adhesion Targeting of ACF7. Nat.Commun. 2016, 7, 11692

20. Zhen-Feng Chen*, Qi-Pin Qin, Jiao-Lan Qin, JieZhou, Yu-Lan Li,Nan Li, Yan-Cheng Liu, HongLiang*.Water-soluble ruthenium(II) complexeswithchiral 4-(2,3-Dihydroxypropyl)-formamide oxoaporphine (FOA): in vitro andinvivo anticancer activity by stabilization of G-Quadruplex DNA, inhibition oftelomeraseactivity, and induction of tumor cell apoptosis. J Med. Chem. 2015, 58,4771–4789

21. Zhen-Feng Chen*, Qi-Pin Qin, Jiao-Lan Qin,Yan-Cheng Liu,Ke-Bin Huang, Yu-Lan Li, Ting Meng, Guo-Hai Zhang, Yan Peng,Xu-Jian Luo, HongLiang*.  Stabilization of G-quadruplex DNA, inhibition oftelomeraseactivity, and tumor cell apoptosis by organoplatinum(II) complexeswithoxoisoaporphine. J Med. Chem.,2015, 58, 2159–2179

22. Ming-HuaZeng*, Min-XiaYao, Hong Liang*,Wei-XiongZhang, Xiao-MingChen. ASingle-Molecule-Magnetic, Cubane-Based,Triangular Co12 Supercluster. Angew.Chem. Int. Ed., 2007, 46, 1832–1835

Editorial Articles

1. Editorial: Thedevelopments of metal-based agents against lung cancer, Frontiers inPharmacology. Front. Pharmacol., 08 December 2022

2. HSA IIA subdomain-baseddeveloping anticancer metal pro-drug: a new and improved approach. Future Med Chem., 2016, 8: 89-91.

3. HSA-based drugdevelopment and drug delivery systems. Curr Pharm Design., 2016, 21: 1784. (Medical Science SCI Division 2)  

4. HSA-basedanti-inflammatory therapy: a new and improved approach. Future Med Chem., 2014, 6: 119-21. (Medical Science SCI Division 2)

Research Projects

1. Training Projectfor Candidates for the Academician of the Chinese Academy of Engineering (2017.1-2021.12, ¥ 15,000,000)

2. National NaturalScience Foundation of China (Major Program): Developing Metal-based Anti-tumorComplexes from Active Components of Traditional Chinese Medicine (2015.1-2019.12, ¥ 3,600,000)

3. Project of Plan973: A Research on Developing Metal-based Anti-tumor Complexesfrom Active Components of Traditional Chinese Medicine and Chemical Assembly and ActivityEvaluation on Natural Cyclic Peptide Potential Drugs (2012-2015, ¥ 2,550,000)

4. Innovative Teams Project of Ministry ofEducation of China (Academic Leader, rank No.2) : (2013-2016, ¥ 4,500,000; 2017-2019, ¥ 3,000,000）

5. NationalNatural Science Foundation of China No. 21171043: A Research on theInteraction Among Anti-tumor Phytomedicines,Metal-based Drugs and Human Serum Albumin(2012.1-2015.12, ¥ 800,000)

Titles

1. Leading Talent of National “Ten-thousand Talents Program” 2016

2. Firstly Selected Candidates from Guangxi for the Academician of the Chinese Academy of Engineering 2016

3. Award for Special Contribution in Development of the West Regions in China 2008 (China Association for Science and Technology)

4. National Excellent Worker Advanced in Science and Technology 2005

5. 3^rd Youth Teacher of Higher Education Award Winner 2002 (China’s Ministry of Education)

6. China Youth Science and Technology Award Winner 2001

7. China’s National Youth Scholar of Outstanding Contribution 1999

8. Guangxi Excellent Professional Technician 1999

9. First Level Candidates for Guangxi “Ten, Hundred, Thousand Talents Project” 1998

10. Firstly Selected Candidates for National Hundred-Thousand-Ten Thousand Talents Project 1996

11. Special Government Allowances of the State Council 1996

12. Guangxi Excellent Expert 1996