Professor Pan Yingming and Teacher Tang Haitao's research team have made breakthroughs in heterogeneous catalysis .In this paper, two new polysubstituted thiazole derivatives were synthesized by the intramolecular cyclization through K₂CO₃-promoted. Pd-metalated phosphorus-doped porous organic polymer (POPs) was used as heterogeneous catalyst, no obvious aggregation and loss of any catalyst activity were observed after 10 runs of the reactions. Furthermore, the in vitro anticancer activity of these new compounds were tested with MTT assay, and compound 4b exhibited good antitumor activity toward T-24 and A549 cells, and could induce A549 cell apoptosis, elevated intracellular ROS levels, and decreased the mitochondrial membrane potential.