基本介绍

广西师范大学天然药物与功能食品助剂科技成果转化中试研究基地主任、广西民族药协同创新中心副主任，重点实验室“药用资源化学研究方向” 学术带头人，教授，博士生导师。广西“特聘专家”、广西“新世纪十百千人才工程”第二层次人选。中国化学会会员、中国化工学会专家库专家，中国中医药信息学会中医临床药学分会常务理事、广西化学化工学会专家库专家，广西化学化工学会理事，河北省杂环化合物重点实验室学术委员会副主任、广西科技界智库决策咨询专家，《广西植物》、《广西师范大学学报》编委和Chem. Sci., J. Med. Chem., J. Nat. Prod., Adv. Synth. Catal.,J. Org..Chem., Eur. J. Med.Chem., Phytomed., Phytochem., J. Med. Food., Pharm.Bio., New J. Chem.., Molecular Nutrition&Food Research等20余种SCI刊物的特约审稿人。

先后主持973前期研究专项1项、国家自然科学基金项目6项、国际合作项目1项、国家科技支撑计划项目子课题1项，以及高等学校博士学科点专项基金、广西重点研发计划和重点项目等其他省部级、厅级课题14项；以第三成员参加国家自然科学基金重点项目1项、973前期研究专项1项。共在Nat.Commun.、Sci. Chi. Chem.、Org.Lett.、Green Chem.、Chem.Commun.、J. Med. Chem.等化学和药学类期刊发表论文300余篇，引用4530次，H指数45，单篇最高引用频次180次；参编英文专著1部。获得广西自然科学/科学进步奖二等奖8项、三等奖2项。获12项国家发明专利授权，部分新产品已被美国Sigma-Aldrich等公司采用。在国际和全国学术会议做邀请报告5次。已培养博士7名、硕士70名。

教育背景

1996.9–2000.6, 兰州大学, 生物化学, 博士, 导师: 王锐
1987.9–1990.7, 中国科学院西北高原生物研究所, 植物化学, 硕士, 导师: 杨海荣
1983.9–1987.6, 兰州大学, 植物生理, 学士, 导师: 郑海金

工作经历

2010.6- 广西师范大学化学与药学学院，教授/博士生导师

2004.12-2010.6 广西师范大学化学化工学院，教授

2000/07-2004/12 广西师范大学，化学化工学院，副研究员/副教授

1990/07-1996/06 中国科学院西北高原生物研究所，植物化学研究室，助理研究员

荣誉及奖励

（1）广西“特聘专家”（2018）

（2）广西“十百千”人才工程第二层次人选（2007）

讲授的课程

天然药物化学、波谱解析、天然产物开发与利用、中药鉴定及质量控制、表征技术

研究领域

主要研究和感兴趣的领域：

中药与天然药物化学、手性药物的结构改造与分离分析研究，功能分子的合成方法学。

近年研究项目

1、国家自然科学基金地区项目(No. 22467005): 新型降二萜菲作为TRPV1抑制剂的抗肿瘤耐药机制研究。（主持）

2、国家自然科学基金面上项目(No. 21977021): 源于紫堇属瑶药的非温敏型生物碱类TRPV1调节剂的发现与结构优化及特异机制研究。（主持）

3、973计划前期研究专项(No.2011CB512005)：基于广西主产中药活性成分的手性氨基膦酸酯基抗肿瘤和抗病毒药物的前期研究。（主持）

4、国家自然科学基金地区项目(No. 81760626): 卷柏属瑶药中新型PDE4 / MMPs双靶点抑制剂的协同抗肿瘤耐药机制。（主持）

5、国家自然科学基金地区项目(No. 81260472): 天然萜烷和氨基酸背景(环)磷酰胺衍生物的手性与肿瘤细胞抑制作用相互关系。（主持）

6、广西重点研发计划（No.2017AB44061）: 基于样品库中新型肿瘤和病毒靶点抑制剂筛查的十种瑶药标准制定。（主持）

7、高等学校博士学科点专项科研基金博导类资助课题（No.20134504110002）: 三类天然骨架含氮磷小分子抗肿瘤药物的串联反应合成与活性研究。（主持）

8、国家自然科学基金重点项目（No.21431001）: 基于中药活性成分的金属抗肿瘤配合物研究。(第三成员)

企业研发项目

1. 三金片浸膏主要化学成分分离鉴定及含量测定用化学对照品纯化制备研究

2. 壮药羊开口主要化学成分分离鉴定和含量测定用化学对照品纯化制备研究

3. 丹参酮系列中药注射剂的中药现代化研究

4. 海南椰油主成分鉴定及含测研究

科研奖励

1. 潘英明、王恒山、王迎春、崔飞虎、李玖零、谢屿阳、钟平富，叠氮-烯经的点击化学新体系与含氮功能分子精准合成新策略，广西科学技术奖自然科学类二等奖，2023年

2. 梁东、王恒山、覃仁俊、陈力健、石伟、樊化、潘其明、毛丹翎、刘涛乾、张斌，山豆根等壮瑶药活性成分与质控技术及应用，广西科学技术进步奖二等奖，2022年

3. 王恒山、潘英明、梁英、陈振锋、张业、徐艳丽，若干绿色催化体系在五元氮杂环药物骨架构筑及手性氮碳磷键侧链修饰中的应用，广西自然科学奖二等奖，2016年

4. 王恒山、潘英明、赵书林、梁英、王凯、何春欢，特色桂药抑制活性氧自由基损伤功效物质基础及作用机制的研究与应用，广西自然科学奖三等奖，2012年

5. 潘英明、王恒山、吴强、黄宇平、杨韶平、张业、王迎春、陈键泉、黄晓超. 松香手性产品深加工技术及其生产工艺的研发与应用，广西科技进步奖二等奖，2015年

6. 方显明、谢金鲜、覃振林、方兴、王恒山、唐友明、兰树彬、欧阳熙林、韦斌，广西特色壮药经血宁胶囊的研发与临床应用，广西科技进步奖二等奖，2014年

7. 赵书林、叶芳贵、卢　昕、田建袅、李舒婷、王恒山，微流控芯片和毛细管电泳新方法及其在单细胞和体液分析中的应用研究，广西自然科学奖二等奖，2010年

8. 赵书林、李舒婷、王恒山等，毛细管电泳新技术及其在生物和药物分析中的应用研究，广西科技进步奖二等奖，2007年

9. 张业、义祥辉、覃雯、潘英明、王恒山、程忠泉、陈力健，基于白藜芦醇骨架改造的化合物的制备及其抗氧化、抗肿瘤活性研究，广西科技进步奖三等奖，2014年

10. 邱建华、沈星灿、梁宏、赵书林、梁毅、王恒山等，《高师院校化学一流专业“一核心两主线三保障四途径”人才培养体系构建与实践》，广西壮族自治区教学成果一等奖，2021年

代表性成果

合成药物化学方向

1.    Yi-Yu Lin, Yan Lu, Chun-Yun Li, Xue-Fei Ma, Miao-Qing Shao, Yu-Hao Gao,Yu-Qing Zhang, Hai-Ning Jiang, Yan Liu, Yang Yang, Li-Dong Huang, Peng Cao, Heng-ShanWang*, Jin Wang*, Ye Yu*. Finely ordered intracellulardomain harbors anallosteric site to modulatephysiopathological function of P2X3 receptors. NatureCommunications, 2024, 15, 7652.

2.    Meng Wang, Guoxiu Cao, Junjie Zhou, Jinyuan Cai, Xianjie Ma, Zhikun Liu*,Xiaochao Huang*, Hengshan Wang*. Ligustrazine-Derived Chalcones-ModifiedPlatinum(IV) Complexes Intervene in Cisplatin Resistance in Pancreatic Cancerthrough Ferroptosis and Apoptosis. J.Med. Chem., 2023, 66(19):13587-13606.

3.    Liu Zhikun, Wang Meng, Huang Rizhen, Hu Tianhui, Jing Yi, Huang Xiaochao,Hu Weiwei, Cao Guoxiu*, Wang Hengshan*. Novel Indole-Chalcone Derivative-Ligated Platinum(IV) Prodrugs Attenuate CisplatinResistance in Lung Cancer through ROS/ER Stress and Mitochondrial Dysfunction. J. Med. Chem., 2023, 66(7): 4868-4887.

4.    Meng Wang, Guimei Li, Guiyang Jiang, Jinyuan Cai, Zhikun Liu, RizhenHuang*, Xiaochao Huang*, Hengshan Wang*. Novel NF-κBInhibitor-Conjugated Pt(IV) Prodrug to Enable Cancer Therapy through ROS/ERStress and Mitochondrial Dysfunction and Overcome Multidrug Resistance. J. Med. Chem., 2024, 67, 8, 6218–6237.

5.    RizhenHuang, Xiaoteng Jing, Xiaochao Huang, Yingming Pan, Yilin Fang, Guibin Liang,Zhixin Liao, Hengshan Wang*,Zhenfeng Chen*, and Ye Zhang*. Bifunctional Naphthoquinone Aromatic Amide-OximeDerivatives Exert Combined Immunotherapeutic and Antitumor Effects throughSimultaneous Targeting of Indoleamine-2,3-Dioxygenase and Signal Transducer andActivator of Transcription 3. J. Med.Chem., 2020, 63(4):1544-1563.

6.    Xiang-Jun Peng, Hai-Ping He , Qian Liu , Kun She , Bao-Qi Zhang , Heng-ShanWang*, Hai-Tao Tang*, Ying-Ming Pan*. Photocatalyst-controlled and visiblelight-enabled selective oxidation of pyridinium salts. Scie. ChinaChem., 2021,64(5): 1-8.

7.       Meng Wang, Guimei Li,Guiyang Jiang, Jingyuan Cai, Wentian Zhong, Rizhen Huang, Zhikun Liu*, XiaochaoHuang*, Heng-Shan Wang*. Dual-targeting tumor cells hybrids derived fromPt(IV) species and NF-κB inhibitors enables cancer therapy throughmitochondrial dysfunction and ER stress and overcomes cisplatin resistance. Eur. J Med. Chem., 2024, 266, 116095.

8.    Xiaochao Huang, Yuanhang Chen, Wentian Zhong, Zhikun Liu*, Haijiang Zhang,Bin Zhang*, Hengshan Wang*. Novel combretastatin A-4 derivativecontaining aminophosphonates as dual inhibitors of tubulin and matrixmetalloproteinases for lung cancer treatment. Eur. J Med. Chem., 2022, 244:114817.

9.    Xiaochao Huang*, Meng Wang, Qinghong You, Jing Kong, Haijiang Zhang,Chunhao Yu, Yanming Wang, Hengshan Wang*, Rizhen Huang*. Synthesis,mechanisms of action, and toxicity of novel aminophosphonates derivativesconjugated irinotecan in vitro and in vivo as potent antitumor agents. Eur.J. Med. Chem., 2020, 189, 112067.

10.    Xiao-Chao Huang, Xiaochao Huang, Rizhen Huang, Zhimei Wang, Lingxue Li,Shaohua Gou*, Zhixin Liao, Heng-Shan Wang*. Pt(IV) complexesconjugating with chalcone analogue as inhibitors of microtubule polymerizationexhibited selective inhibition in human cancer cells. Eur. J. Med. Chem.,2018,146, 435-450.

11.    XiaochaoHuang, Shixian Hua, Rizhen Huang, Zhikun Liu, Shaohua Gou*, Zhimei Wang, ZhixinLiao, Hengshan Wang*. Dual-targeting antitumor hybrids derived from Pt(IV)species and millepachine analogues. Eur. J. Med. Chem.,2018,148, 1-25.

12.    Ri-ZhenHuang, Gui-Bin Liang, Xiao-Chao Huang, Bin Zhang, Mei-Mei Zhou, Zhi-Xin Liao*, Heng-ShanWang*.Discovery of dehydroabietic acid sulfonamide based derivatives as selectivematrix metalloproteinases inactivators that inhibit cell migration andproliferation. Eur. J. Med. Chem., 2017, 138,979-992.

13.    XiaochaoHuang, Rizhen Huang, Lingxue Li, Shaohua Gou, Hengshan Wang*. Synthesisand biological evaluation of novel chalcone derivatives as a new class of microtubuledestabilizing agents. Eur. J. Med. Chem., 2017, 132, 11-25.

14.    Jian-MeiQin, Ri-Zheng Huang, Xiao-Chao Huang, Gui-Yang Yao, Ying-Ming Pan* and Heng-Shan Wang*. Terminal functionalized thiourea-containing dipeptides asmultidrug- resistance reversers that target 20S proteasome and cellproliferation. Eur. J. Med. Chem., 2017, 126, 259-269.

15.    Man-YiYe, Gui-Yang Yao, Ying-Ming Pan, Zhi-Xin Liao, Ye Zhang, Heng-Shan Wang*. Synthesis and antitumor activities of novelα-aminophosphonate derivatives containing an alizarin moiety. Eur.J. Med. Chem., 2014, 83,116–128.

16.    Jian-FeiLi, Ri-Zhen Huang, Gui-Yang Yao, Man-Yi Ye,Heng-Shan Wang*, Ying-Ming Pan*, Jing-Teng Xiao. Synthesis and biologicalevaluation of novel aniline-derived asiatic acid derivatives as potentialanticancer agents. Eur. J. Med. Chem., 2014, 86,175–188.

17.    Hong-EnQu , Ri-Zhen Huang, Gui-Yang Yao, Jiu-Ling Li, Man-Yi Ye, Heng-Shan Wang*, Liangxian Liu*. Synthesis and pharmacologicalevaluation of novel bisindole derivatives bearing oximes moiety: Identificationof novel proapoptotic agents, Eur. J. Med. Chem., 2015, 95, 400−415.

18.    Xiao-Chao Huang, Le Jin, Meng Wang, Dong Liang,Zhen-Feng Chen, Ye Zhang*,Ying-Ming Pan, Heng-Shan Wang*. Design, synthesis and in vitroevaluation of novel dehydroabietic acid derivatives containing a dipeptidemoiety as potential anticancer agents. Eur.J. Med. Chem., 2015, 89, 370−385.

19.    Shi-XianHua, Ri-Zheng Huang, Man-Yi Ye, Ying-Ming Pan, Gui-Yang Yao, Ye Zhang*, Heng-Shan Wang*, Design, synthesis andin vitro evaluation of novel ursolic acid derivatives as potential anticanceragents. Eur. J. Med. Chem.,2015, 95, 435−452.

20.    XiaochaoHuang, Rizheng Huang, Zhixin Liao, Yingming Pan, Shaohua Gou*, Hengshan Wang*.Synthesis and pharmacological evaluation of dehydroabietic acid thioureaderivatives containing bisphosphonate moiety as an inducer of apoptosis. Eur.J. Med. Chem., 2016, 108, (27), 381-391.

21.    Xiao-ChaoHuang, Meng Wang, Ying-Ming Pan, Gui-Yang Yao, Heng-Shan Wang*, Xiao-Yan Tian, Jiang-Ke Qin, Ye Zhang. Synthesisand antitumor activities of novel thiourea α-aminophosphonates fromdehydroabietic acid. Eur. J. Med. Chem., 2013, 69,508–520.

22.    Lumei Dai , Feng Qin , Yuying Xie, Bin Zhang, Zhijie Zhang, Sijia Liang,Fujia Chen, Xiaochao Huang*, Hengshan Wang*. Antitumor activityand mechanisms of dual EGFR/DNA-targeting strategy for the treatment of lungcancer with EGFRL858R/T790M mutation. Bioorg. Chem., 2023,135:106510.

23.    Meng Wang, Zhikun Liu, Xiaochao Huang, Yuanhang Chen, Yanming Wang, JingKong, Yong Yang, Chunhao Yu, Jin Li, Xu Wang*, Hengshan Wang*.Dual-target platinum(IV) complexes exhibit antiproliferative activity throughDNA damage and induce ER-stress-mediated apoptosis in A549 cells. Bioorg. Chem., 2021, 110: 104741-104741.

24.    XiaochaoHuang*, Meng Wang, Chungu Wang, Weiwei Hu, Qinghong You, Tianhua Ma, Qiang Jia,Chunhao Yu, Zhixin Liao*, Hengshan Wang*. Synthesis and biologicalevaluation of novel millepachine derivative containing aminophosphonate esterspecies as novel anti-tubulin agents. Bioorg. Chem., 2020, 94,103486.

25.    Le Jin,Lumei Dai,Min Ji*,Hengshan Wang*. Mitochondria-targeted triphenylphosphonium conjugatedglycyrrhetinic acid derivatives as potent anticancer drugs. Bioorg. Chem., 2019,85, 179-190.

26.    Xiaochao Huang, Meng Wang, Chungu Wang, Weiwei Hu, Qinghong You, Yong Yang,Chunhao Yu, Zhixin Liao, Shaohua Gou*, Hengshan Wang*, Dual-targetingantitumor conjugates derived from platinum(IV) prodrugs and microtubuleinhibitor CA-4 signifcantly exhibited potent ability to overcome cisplatinresistance. Bioorg. Chem., 2019, 92: 1032362.

27.    HuangX, Liu Z, Wang M, Yin X, Wang Y, Dai L, Wang H*.Platinum(IV) complexes conjugated with chalcone analogs as dual targetinganticancer agents: In vitro and in vivo studies. Bioorg. Chem.,2020 , 105:104430.

28.    Cai-Wen Fan, Mei-Shan Li, Xi-Xi Song, Li Luo, Jing-Chen Jiang, Jia-Zi Luo*,Heng-Shan Wang*. Discovery ofnovel 2-oximino-2-indolylacetamide derivatives as potent anticancer agentscapable of inducing cell autophagy and ferroptosis. Bioorg. Med. Chem., 2023, 80:117176.

29.    Le Jin,Rizhen Huang, Xiaochao Huang, Bin Zhang, Min Ji* and Hengshan Wang*,Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivativesas Hsp90–Cdc37 interaction disruptors that inhibit cell migration and reversedrug resistance. Bioorgan. Med. Chem., 2018, 26, 1759–1775

30.    Yu-YangXie, Ying-Chun Wang, Yan He, Da-Chao Hu, Heng-Shan Wang*, Ying-MingPan*. Catalyst-Free Synthesis of Fused 1, 2, 3-Triazole and IsoindolineDerivatives via Intramolecular Azide-Alkene Cascade Reaction. Green Chem., 2017, 19, 656–659.

31.    KunShe, Feng Liang, Shichao Tian, Hengshan Wang*, Gavin Chit Tsui, Quande Wang*.Organocatalytic Three-omponent Acyldifluoromethylation of Vinylarenes viaN-Heterocyclic Carbene-Catalyzed Radical Relay. Org. Lett., 2022,24: 4840-4844.

32.    Yong-Zhou Pan, Qiang Xia, Jin-Xiu Zhu, Ying-Chun Wang, Ying Liang, HengshanWang,* Hai-Tao Tang,* and Ying-Ming Pan*. Electrochemically MediatedCarboxylative Cyclization of Allylic/Homoallylic Amines with CO2 atAmbient Pressure. Org. Lett., 2022, 24, 8239−8243.

33.   Yan He, Yingchun Wang, Xinping Liang, BinHuang, Hengshan Wang*, and Ying-Ming Pan*. Palladium-CatalyzedThree-Component Reaction: A Novel Method for the Synthesis of N‑AcylPropiolamides .Org. Lett., 2018, 20, 22, 7117-7120.

34.   Xiao-Ying Huang, Rui Ding, Zu-Yu Mo, Yan-Li Xu, Hai-Tao Tang,Heng-Shan Wang*, Yan-Yan Chen, Ying-Ming Pan*. PhotocatalyticConstruction of S–S and C–S Bonds Promoted by Acridinium Salt: An UnexpectedPathway To Synthesize 1, 2, 4-Dithiazoles.Org. Lett., 2018, 20, 4819−4823.

35.   Jiu-ling Li, Wei-ze Li, Ying-chun Wang,Qiu Ren, Heng-shan Wang,* andYing-ming Pan*. Palladium(II)-Catalyzed C-C and C-O Bonds Formation for theSynthesis of C1-Benzoyl Isoquinolines from Isoquinoline N-Oxides and NitroAlkenes. Chem. Commun., 2016, 52,10028-10031.

36.   Jiu-ling Li,Ying-chun Wang, Wei-ze Li, Heng-shanWang*, Dong-liang Moa andYing-ming Pan*. Facile synthesis of 2,5‐disubstituted oxazoles via acoppercatalyzed cascade reaction of alkenes with azides. Chem. Commun., 2015, 51, 17772-17774.

37.   Bin Zhang,Xiaochao Huang,Hengshan Wang*,Shaohua Gou*. Promoting antitumor efficacy by suppressing hypoxia via nano self-assemblyof two irinotecan-based dual drug conjugates having a HIF-1α inhibitor. J. Mater. Chem. B, 2019, 7(35): 5352-5362.

38.    Xiaochao Huang, Rizhen Huang, Shaohua Gou, Zhimei Wang, Hengshan Wang*. Anticancer Platinum(IV) Prodrugs ContainingMonoaminophosphonate Ester as a Targeting Group Inhibit MatrixMetalloproteinases and Reverse Multidrug Resistance. Bioconjugate Chem., 2017, 28 (4),1305-1323.

39.   Xiaochao Huang, Rizhen Huang,Shaohua Gou*, ZhimeiWang, Zhixin Liao, Hengshan Wang*. Combretastatin A-4Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt (IV)Moiety with a Unique Mode of Action. BioconjugateChem., 2016, 27(9): 2132-2148.

40.    Yan He,Ying-Chun Wang, Kun Hu, Xiao-Ling Xu, Heng-Shan Wang*, Ying-Ming Pan*.Palladium-Catalyzed Synthesis of 5-Iminopyrrolones through Isocyanide DoubleInsertion Reaction with Terminal Alkynes and Water. J. Org. Chem., 2016, 81(23), 11813-11818.

41.    Yan-liXu, Ying-Ming Pan,* Qiang Wu, Heng-ShanWang*, Pei-zhen Liu. Regioselective Synthesis of 1,3,5-Substituted Benzenesvia the InCl3/2-iodophenol- Catalyzed Cyclotrimerization of Alkynes.J.Org. Chem. 2011, 76(20),8472-08476.

42.    Ying-ChunWang, Yu-Yang Xie, Hong-En Qu, Heng-ShanWang*, Ying-Ming Pan*, Fu-Ping Huang. Ce(OTf)3-catalyzed [3+2]cycloaddition of azides with nitroolefins: regioselective synthesis of1,5-disubstituted 1,2,3-triazoles. J. Org. Chem., 2014, 79, 4463−4469.

43.    Jiu-lingLi, Da-chao Hu, Xin-ping Liang, Ying-Chun Wang, Heng-Shan Wang*,Ying-ming Pan*. Praseodymium (III)-Catalyzed Regioselective Synthesis ofC3-N-substituted Coumarins with Coumarins and Azides. J. Org. Chem.,2017, 82, 9006−9011.

44.    Xiu-Jin Meng, Ping-Fu Zhong, Yu-Mei Wang, Heng-Shan Wang*, Hai-TaoTang*, Ying-Ming Pan*.ElectrochemicalDifunctionalization of Olefines: Access to Selenomethyl-Substituted CyclicEthers or Lactones.Adv. Synth. Catal., 2020,362:506-511.

45.    YingchunWang, Jiuling Li, Yan He, Yuyang Xie, HengshanWang,* and Yingming Pan,* Synthesis of Polysubstituted Imidazoles andPyridines via Samarium(III) Triflate-Catalyzed [2+2+1] and [4+2] Annulations ofUnactivated Aromatic Alkenes with Azide.Adv. Synth. Catal., 2015, 357, 3229-3241.

46.    Yu-YangXie, Ying-Chun Wang, Hong-En Qu, Xian-Chun Tan, Heng-Shan Wang*, Ying-Ming Pan*. Regioselective synthesis ofβ-Aryl enaminones and 1,4,5-trisubstituted 1,2,3-triazoles from chalcones andbenzyl azides. Adv. Synth. Catal., 2014,356, 3347–3355.

47.    PeiLiu, Ying-Ming Pan*, Yan-Li Xu, Heng-ShanWang*. PTSA-catalyzed Mannich-type-cyclization-oxidation tandem reactions:one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines andalkynes. Org. Biomol. Chem., 2012, 10, 4696–4698.

48.   Xu Wang, Ying-ming Pan*, Xiao-chao Huang,Zhong-yuan Mao and Heng-shan Wang*.A novel methodology for synthesis of dihydropyrazole derivatives as potentialanticancer agents. Org. Biomol. Chem., 2014, 12, 2028-2032.

49.    Xiaoguang Pan, Min Cao, Song Li, Hengshan Wang*, Xigong Liu*, andLei Liu*. Synthesis of Diarylmethanes Bearing CF3- and CN-Substituted All-carbonQuaternary Centers and Diarylmalononitriles through Cyanation ofδ-Disubstituted Para-Quinone Methides. Eur. J. Org. Chem., 2021, 1643-1646.

50.   Wei-Gen Huang, Heng-Shan Wang*, Guo-Bo Huang, Yong-Ming Wu, Ying-Ming Pan*. Enantioselective friedel–craftsalkylation of n‐methylindoles with nitroalkenes catalyzed by chiralbifunctional abietic‐acid‐derived thiourea‐ZnII complexes. Eur.J. Org. Chem., 2012, 29, 5839–5843.

51.    Gui-YangYao, Ya-Jun Li, Yong-Tao Zhu, Ying-Ming Pan, Fu-Ping Huang, Hengshan Wang*, Zhi-Xin Liao*.Protonation-controlled axial chirality in maleopimaric imides. NewJ. Chem., 2014, 38, 693–699.

52.    Heng-Shan Wang*,Xiao-Yan Tian, Da Yang, Ying-Ming Pan, Qiang Wu, Chun-Huan He. Synthesis andenantiomeric recognition ability of 22-crown-6 ethers derived from rosin acidand BINOL. Tetrahedron: Asymmetry, 2011, 22(4), 381–386.

53.     Jia-Jia Liu, Bao-Qi Zhang, Kun She, JiaoRan, Hui-Fang Li, Heng-Shan Wang, Fang-Xin Wang*, Heng-Shan Wang*.Divergent syntheses of (-)-carvone-derived dimers. Tetrahedron, 2024, 151,133804.

54.    Qi Gao,Shen-Yan Li, Ying-Ming Pan*, Yan-Li Xu, Heng-ShanWang*. The indium-catalysed hydration of alkynes using substoichiometricamounts of PTSA as additive. Tetrahedron, 2013, 69(19),3775–3781.

55.    PeiLiu, Ying-Ming Pan*, Kun Hu, Xiao-Chao Huang, Ying Liang, Heng-Shan Wang*. Ligand-free indium(III)-catalyzed Heck reaction. Tetrahedron,2013, 69(37), 7925–7930.

56.     Ying-Chun Wang, Heng-Shan Wang*, Guo-BaoHuang, Fu-Ping Huang, Kun Hu, Ying-Ming Pan*. A one-pot approach to4,5-dihydropyrazoles from ketones, arylacetylenes, and hydrazines. Tetrahedron,2014, 70, 1621–1628.

57.     Lu-Zhi Liu, Chun-Huan He, Lin Yang, Yan Huang,Qiang Wu, Wen-gui Duan, Heng-shan Wang*,Ying-ming Pan*. Novel C1-symmetric chiral crown ethers bearing rosin acidsgroups: synthesis and enantiomeric recognition for ammonium salts. Tetrahedron,2014, 70, 9545–9553.

58.    Ri-Zhen Huang, Gui-Bin Liang, Mei-Shan Li, Yi-Lin Fang, Shi-Feng Zhao,Mei-Mei Zhou, Zhi-Xin Liao*, Jing Sun* and Heng-Shan Wang*. Synthesisand discovery of asiatic acid based 1,2,3-triazole derivatives as antitumoragents blocking NF-κB activation and cell migration. Med. Chem. Commun.,2019, 10:584-597.

天然药物化学方向

59.     Cai-Wen Fan, Juan Tang , Jing-Chen Jiang , Mei-Mei Zhou , Mei-Shan Li*, Heng-ShanWang*, Pentagalloylglucose suppresses the growth and migration of humannasopharyngeal cancer cells via the GSK3β/β-catenin pathway in vitro and invivo. Phytomedicine, 2022. 102: 154192.

60.    Xi-Lin Ouyang, Feng Qin, Ri-Zhen Huang, Dong Liang,Chun-Gu Wang, Heng-Shan Wang*, Zhi-Xin Liao*. NF-κB inhibitory andcytotoxic activities of hexacyclic triterpene acid constituents from Glechomalongituba. Phytomedicine,2019, 63, 153037

61.    Ri-ZhenHuang, Xiao-Chao Huang, Bin Zhang, Hai-Yang Jia, Zhi-XinLiao*, Heng-ShanWang*.16-O-caffeoyl-16-hydroxylhexadecanoic acid, a medicinal plant-derived phenylpropanoid, induces apoptosis in humanhepatocarcinoma cells through ROS-dependent endoplasmic reticulum stress. Phytomedicine,2018, 41, 33-44.

62.    Bin Zhang, Rizhen Huang,Jing Hua, Hong Liang, Yingming Pan, Lumei Dai, Dong Liang, Hengshan Wang*.Antitumor lignanamides from the aerial parts of Corydalis saxicola. Phytomedicine, 2016, 23(13), 1599-1609.

63.    Cai Yi Wang, Feng Qin, Chun-Gu Wang, Donghwa Kim, Jin-Jun Li, Xian-LanChen, Heng-Shan Wang*, Lee SK*. Novel lignans from Zanthoxylum nitidumand antiproliferation activity of sesaminone in osimertinib-resistant non-smallcell lung cancer cells. Bioorg Chem., 2023, 134:106445.

64.    Wei Jiang, Ri-ZhenHuang, Jing Zhang, Tong Guo, Meng-Ting Zhang, Xiao-Chao Huang, Bin Zhang,Zhi-Xin Liao*, Jing Sun*, Heng-Shan Wang*. Discovery of antitumorursolic acid long-chain diamine derivatives as potent inhibitors of NF-κB.Bioorg.Chem., 2018, 79,265-276.

65.    FengQin, Li Luo, Yu-Chen Liu, Xiang-Long Bo, Fu-Rong Wu, Fan-Fan Wang, Mei-JingTan, You-Quan Wei, Xiao-Bing Dou, Cai Yi Wang, Xi-Shan Huang*,Heng-Shan Wang*.Diisoprenyl-cyclohexene-type meroterpenoids from a mangrove endophytic fungusAspergillus sp. GXNU-Y65 and their anti-nonalcoholic steatohepatitis activityin AML12 cells. Phytochemistry, 2024, 218, 113955.

66.    Feng Qin, Cai YiWang, Chun-Gu Wang, Yao Chen, Jin-Jun Li, Mei-Shan Li, Yan-Kui Zhu, Sang KookLee*, Heng-Shan Wang*. Undescribed isoquinolines from Zanthoxylum nitidum and theirantiproliferative effects against human cancer cell lines. Phytochemistry, 2023, 205:113476.

67.    Lu-Mei Dai, Ri-Zhen Huang, Bin Zhang, Jing Hua, Heng-Shan Wang*, Dong Liang*, CytotoxicTriterpenoid Saponins from Lysimachia foenum-graecum. Phytochemistry, 2017, 136 , 165-174.

68.    Feng Qin, Li Luo, Yao Chen, Gang Wei, Chun-Ce Wei, Xiao-Hua Yang, Yi-LinFang, Heng-Shan Wang*. A newphenylpropanoic acid congener from Zanthoxylum nitidum. Nat. Prod. Res., 2023, 9:1-7.

69.    Feng Qin, Zi-Shuo Song, Li Luo, Xiang-Long Bo, Fu-Rong Wu, Mei-Jing Tan,Fan-Fan Wang, Xi-Shan Huang*, Heng-Shan Wang*. DiisoprenylCyclohexene-Type Meroterpenoids with Cytotoxic Activity from a MangroveEndophytic Fungus Aspergillus sp. GXNU-Y85. Marine Drugs,2024, 22, 58.

70.    WentaoSun, Li Luo, Jiazi Luo, Xixi Song, Demin Tang , Zishuo Song ,Meishan Li*, Hengshan Wang*.Phytoconstituents of Selaginella effusa Alston and Their α-Glucosidase as wellas Urease Inhibitory Activities.Chem. Biodivers.,2023, 20, e202300387.

71.    Xi-Lin Ouyang, Tian-Hua Ma, Gui-Liang Xie, Shan Chen, Heng-Shan Wang*,Qiang Jia, En-De Zhang, and Jing-Hua Huang. Acetylated rhamnose triterpenoidsaponins from Glechoma longituba analyzed by LC-Q-TOFMS.Chem. Biodivers.,2021, 18: e2100272.

72.    Feng Qin, Mei-Shan Li, Jin-Jun Li, Yue Wang, Ke Wang, Jian-Yu Zhou, DongLiang*, Heng-Shan Wang*. Four New Sesquiterpenoids from Zanthoxylumnitidum. Chem. Biodivers., 2022, 19: e202200449.

73.    Fanfan Wang, Ming Li, Cong Lin, Sha Jin, Hongyuan Li, Yuyuan Lu, HengshanWang*, Hongshuang Wang*, Xiaohui Wang*. Cannabidiol-dihydroartemisininconjugates for ameliorating neuroinflammation with reduced cytotoxicity. Bioorg. Med. Chem., 2021, 39: 116131-116131.

74.    Wei-NaYao, Ri-Zhen Huang, Jing Hua, Bin Zhang, Chun-Gu Wang, Dong Liang*, Heng-ShanWang*. Selagintamarlin A, A 1H-2-BenzopyranSelaginellin Analogue Possessing an Unprecedented Skeleton from Selaginella tamariscina. ACS Omega, 2017,2 (5): 2178–2183.

75.    Lu-MeiDai, Ri-Zhen Huang, Jinjin Zhu, Zi-Shuo Song, Zhao-Guo Hong, Feng Qin*, HengshanWang*. Targeted isolation, structural characterization and cytotoxicityevaluation of isoquinoline alkaloids from Corydalis Saxicola. Journal ofMolecular Structure, 2023,  1293,136240.

76.    Feng Qin, Lumei Dai, Bin Zhang, Rizhen Huang, Fanfan Wang, Jiangke Qin,Dong Liang*, Hengshan Wang*. (±)-Corysaxicolaine A: a pair of antitumorenantiomeric alkaloid dimers from Corydalis saxicola. Org. Biomol. Chem., 2022, 20:1396-1400.

77.    Ying-chun Wang, Yu-yang Xie, Xian-chun Tan, Heng-shan Wang*, Ying-ming Pan*.Sc(OTf)3-mediated 1,3-dipolar cycloaddition-ringcleavage-rearrangement: a highly stereoselective access toZ-beta-enaminonitriles. Org. Biomol. Chem., 2015, 13, 513−519.

78.   Li Luo, Jia-Zi Luo,Xi-Xi Song, Cai-Yi Wang, De-Ming Tang, Wen-Tao Sun, Cai-Wen Fan, Mei-Shan Li*, Heng-ShanWang*. Alkaloids from Corydalis saxicola and theirantiproliferative activity against cancer cells. Fitoterapia,2024, 173, 105791.

79.    Feng Qin, Chun-Gu Wang, Mei-Shan Li, Jin-Jun Li, Gang Wei, Na Liao, Heng-ShanWang*. Structurally diverse isobutylamides from Zanthoxylum nitidum. Fitoterapia,2023, 164:105381.

80.    Jia-Zi Luo, Mei-Shan Li, Xi-Xi Song, Yi-Lin Fang, Hai-Ning Mo, Jing-ChenJiang, Hai-Yan Zhao, Heng-Shan Wang*. New alkaloids and their in vitroantitumor activity of Corydalis balansae. Fitoterapia, 2022, 162:105289.

81.    Feng Qin, Fan-Fan Wang, Chun-Gu Wang, Yao Chen, Mei-Shan Li, Yan-Kui Zhu,Xiao-chao Huang, Cai-Wen Fan*, Heng-Shan Wang*. The neurotrophic and antineuroinflammatory effects of phenylpropanoidsfrom Zanthoxylum nitidum var. tomentosum (Rutaceae). Fitoterapia,2021,153: 104990.

82.    Xi-LinOuyang, Wen-Hua Mao, Chun-Gu Wang, Ying-Ming Pan, Dong Liang*, Heng-Shan Wang*.Fivenew 11α, 12α-epoxy pentacyclic triterpenoid saponins with anticoagulant activities from Glechomalongituba.Fitoterapia, 2019, 138: 104345

83.    YuanZhu, Ri-Zhen Huang, Chun-Gu Wang, Xi-Lin Ouyang, Xiao-Teng Jing, Dong Liang*,and Heng-Shan Wang*. New inhibitorsof matrix metalloproteinases 9 (MMP-9): lignans from Selaginella moellndorffii. Fitoterapia,2018,130: 281–289

84.    Ri-Zhen Huang, Le Jin,Chun-Gu Wang, Xiao-Jing Xu, Ying Du, Na Liao, Min Ji, Zhi-Xin Liao*, Heng-ShanWang*. A pentacyclic triterpene derivative possessing polyhydroxyl ring Asuppresses growth of HeLa cells by reactive oxygen species-dependent NF-κBpathway.Eur. J. Pharmacol., 2018, 838: 157-169.

85.    Chun-GuWang, Wei-Na Yao, Bin Zhang, Jing Hua, Dong Liang*, Heng-Shan Wang*. Lungcancer and matrix metalloproteinases inhibitors of polyphenols from Selaginellatamariscina with suppression activity of migration. Bioorg. Med. Chem. Lett., 2018, 28, 2413-2417.

86.    Lu-Mei Dai, Ri-ZhenHuang, Bin Zhang, Jing Hua, Hai-Bing Liao, Heng-Shan Wang*, Dong Liang*, Threenew triterpenoid saponins from the aerial parts of Lysimachia foenumgraecum.  PhytochemistryLetters, 2017, 22, 133-137.

87.    Cai YiWang, Ji Sun Lee, Xiang Dong Su, Hong Xu Li, Sang Kook Lee, Heng-Shan Wang*Young Ho Kim* and Seo Young Yang*. Three new constituents from the aerial partsof Tetrastigma hemsleyanum and theircytotixic and soluble epoxide hydrolase inhibitory activities. Phytchem.Lett., 2018, 27: 25-29.

88.   Ri-Zhen Huang, Bin Zhang, Xiao-ChaoHuang, Gui-Bin Liang, Jian-Mei Qin, Ying-Ming Pan, Zhi-Xin Liao*, Heng-Shan Wang*. Synthesis and biological evaluation of terminalfunctionalized thiourea-containing dipeptides as antitumor agents.RSCAdvances,2017, 7(15),8866-8878

89.    QiangWu, Pei Liu, Ying-Ming Pan*, Yan-Li Xu, Heng-ShanWang*. Cu (otf) 2-catalyzed three-component annulation reaction: One-potsynthesis of 4, 5-dihydropyrazole from aldehydes, hydrazines and alkenes. RSCAdvances. 2012, 2: 10167–10170.

90.    Ri-Zhen Huang, Cai-YiWang, Jian-Fei Li, Gui-Yang Yao, Ying-Ming Pan, Man-Yi Ye, Heng-Shan Wang*, Ye Zhang*. Synthesis, antiproliferative andapoptosis-inducing effects of novel asiatic acid derivatives containingα-aminophosphonates.RSC Advances.,2016, 6: 62890–62906.

91.    Yan He,Yu-yang Xie, Ying-chun Wang, Xiao-min Bin, Da-chao Hu, Heng-shan Wang*,Ying-ming Pan*. TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylicketones and TMSN.RSC Advances, 2016, 6(64),58988-58993.

92.   Na Liao, Mei-Shan Li,Feng Qin*, Jing-Chen Jiang, Ri-Da Luo, Xian-Lan Chen, Mei-Mei, Zhou, Yan-Kui Zhu, Heng-ShanWang*. A new phenolic acid from Zanthoxylum nitidum var. tomentosum (Rutaceae)and its chemotaxonomic significance. Biochem.Syst. Ecol., 2021,99, 104351.

93.   Gui-yang Yao, Man-yiYe, Ri-zhen Huang, Ya-jun Li, Yong-tao Zhu, Ying-ming Pan, Zhi-Xin Liao*, Heng-shan Wang*. Synthesis andantitumor activity evaluation of maleopimaric acid N-aryl imide atropisomers. Bioorg.Med. Chem. Lett., 2013, 23, 6755-6758

94.    Gui-YangYao, Man-Yi Ye, Ri-Zhen Huang, Ya-Jun Li, Ying-Ming Pan, Qing Xu, Zhi-XinLiao*, Heng-Shan Wang*.Synthesis and antitumor activities of novel rhein α-aminophosphonatesconjugates. Bioorg. Med. Chem. Lett., 2014, 24, 501–507

95.    Xiao-ChaoHuang, Meng Wang, Heng-Shan Wang,Zhen-Feng Chen, Ye Zhang*, Ying-Ming Pan*. Synthesis and antitumor activitiesof novel dipeptide derivativesderived from dehydroabietic acid. Bioorg.Med. Chem. Lett., 2014, 24,1511–1518.

96.    Xiao-ChaoHuang, Meng Wang, Ying-ming Pan, Xiao-Yan Tian, Heng-shan Wang*, Ye Zhang*. Synthesis and antitumor activities ofnovel α-aminophosphonates dehydroabietic acid derivatives. Bioorg. Med. Chem. Lett.,2013, 23(19), 5283–5289.

97.   Pan, Yingming*; He,Chunhuan; Wang, Hengshan*; Ji,Xiaowen; Wang, Kai; Liu, Peizhen Antioxidant activity of microwave-assistedextract of Buddleia officinalis and its major active component. FoodChemistry,2010, 121, 15, 497–502.

98.   Yingming Pan,*, Zhiren Zhu, Zhili Huang, Hengshan Wang*, Ying Liang, Kai Wang,Qian Lei, Min Liang. Characterisation and free radical scavenging activities ofnovel red pigment from Osmanthus fragrans’seeds. Food Chemistry, 2009, 112: 909–913.

99.   Yingming Pan*, Kai Wang, SiqinHuang, Hengshan Wang*, Xiaomei Mu, Chunhuan He, Xiaowen Ji, Jie Zhangand Fujuan Huang. Antioxidant activity of microwave- assisted extract of longan(Dimocarpus Longan Lour.) peel.Food Chemistry, 2008, 106(3): 1264-1270.

100.YingmingPan*, Jinchan Zhu, Hengshan Wang*,Xiaopu Zhang, Ye Zhang, Chunhuan He, Xiaowen Ji, Haiyun Li. Antioxidantactivity of ethanolic extract of Cortex fraxini and use in peanut oil.Food Chemistry,2007,103: 913–918.

101. Yingming Pan*, Xiaopu Zhang, Hengshan Wang*, Ying Liang, JinchanZhu, Haiyun Li, Zhi Zhang, Qingmao Wu. Antioxidantpotential of ethanolic extract ofPolygonum cuspidatum and application in peanut oil. Food Chemistry, 2007, 105(4):1518-1524.

102.  Heng-Shan Wang*, Dian-Hua Gan,Xiao-Pu Zhang, Ying-Ming Pan. Antioxidant capacity of the extracts from pulp ofOsmanthus fragrans and its components. LWT - Food Sci. Technol.2010, 43, 319–325.

103. Ming-Xiong Tan, Dian-hua Gan, Liu-xin Wei,Ying-ming Pan, Shao-qing Tang, Heng-shanWang*. Isolation and characterization of pigment from Cinnamomum burmannii’peel. Food Res. Int. 2011, 44: 2289–2294.

104. Qi-Ming Pan, Yu-Huan Li, Jing Hua, Fu-PingHuang, Heng-Shan Wang, Dong Liang*. Antiviral Matrine-type Alkaloidsfrom the Rhizomes of Sophora tonkinensis. J. Nat. Prod., 2015, 78(7),1683-1688.

105.  Le Jin, Hong-En Qu, Xiao-Chao Huang,Ying-Ming Pan, Dong Liang, Zhen-Feng Chen, Heng-ShanWang,* and Ye Zhang*. Synthesis and Biological Evaluation of Novel Dehydroabietic AcidDerivativesConjugated with Acyl-Thiourea Peptide Moiety as AntitumorAgents, Int.J. Mol. Sci.2015, 16, 14571-14593.

106.  Man-Yi Ye, Gui-Yang Yao, Jing-Chen Wei,Ying-Ming Pan*, Zhi-Xin Liao, Heng-ShanWang*. Synthesis, cytotoxicity, DNA binding and apoptosis of rheinphosphonate derivatives as antitumor agents. Int. J. Mol. Sci., 2013,14, 9424–9439.

107. Guiyang Yao, Manyi Ye, Yongtao Zhu, ZhixinLiao*,Hengshan Wang*.Synthesis and pharmacological evaluation of maleopimaric N-arylimides:Identification of novel proapoptotic agents, Anti-Cancer Agent. Med. Chem.,2016, 16(6), 755-762. 

108. Huang, R.Z., Hua, S. X., Wang, C. Y., Pan, Y. M., Qin, J. M., Ding, Z. Y., Zhang, Y*.& Wang, H. S*.4-Methylumbelliferones Analogues as Anticancer Agents: Synthesis and in CellPharmacological Studies.Anti-CancerAgent. Med. Chem., 2017, 17(4), 576-589.

109. Pingtan Lin, Shulin Zhao*, Xin Lu, Fanggui Ye,Hengshan Wang*. Preparationof a dual- enzyme co-immobilized capillary microreactor and simultaneousscreening of multiple enzyme inhibitors by capillary electrophoresis,J. Sep. Sci., 2013, 36(15): 2538–2543.

110. Ying-Chun Wang, Chun-Hua Su, Fang-Yao Li,Lu-Zhi Liu, Ying-Ming Pan, Xiu-Rong Wu, Heng-Shan Wang*. Syntheses,characterization and fluorescent properties of two series of dehydroabieticacid C-ring derivatives. Spectrochim. Acta A, 2010, 76, 328–335.

111.  Xi-Lin Ouyang, L-X Wei , Heng-Shan Wang*, Ying-Ming Pan*.Antioxidant activity and phytochemical composition of Osmanthus fragrans'pulps. S. Afr. J. Bot., 2015, 98: 162–166.

112. XLOuyang, XM Fang, YM Pan, LX Wei, HS Wang*, Development of HPLCFingerprint for the Quality Control of Euonymusfortunei and Distinguishing from Related Species. Acta Chromatogr.,2012, 24(2): 301-316.

113. Rui-Yun Yang, Xi-Lin Ouyang, Dian-Hua Gan, Heng-Shan Wang*, Yi-Zheng Li, Ying-MingPan*. Isolation and Determination of Iridoid Glycosides From the Seeds of Osmanthus fragrans by HPLC.Anal.Lett., 2012, 46: 745–752.

114.  Xi-LinOuyang,, Liu-Xin Wei, Xian-Ming Fang, Heng-ShanWang*, Ying-Ming Pan*. Flavonoid constituents of Euonymus fortune. Chem. Nat. Compd., 2013, 49(3),428–431.

115. Yi-Zheng Li,Ying-Ming Pan, Xiao-Yan Huang, Heng-ShanWang*. Withanolides from Physalis alkekengi var. francheti. Helv.Chim. Acta. 2008, 91: 2284－2291.

116. Hengshan Wang, Shulin Zhao*, Min He, Zhicai Zhao, Yingming Pan, QianLiang. Sodium maleopimaric acid as pseudostationary phasefor chiral separations of amino acids derivatives by capillary micellarelectrokinetic chromatography. J. Sep. Sci., 2007, 30:2748-2753.

117.  Hengshan.Wang, Rongcan Zhang, Shulin Zhao*, Lidong Tang and YingmingPan. Synthesis and application of dehydroabietylisothiocyante as a newchiralderivatizing agent for the enantiomeric separation of chiral compounds bycapillary electrophoretic. Anal. Chim. Acta2006, 560: 64–68.

118. Shulin Zhao*, Rongcan Zhang, Hengshan Wang*,Lidong Tang and Yingming Pan. Capillary electrophoresis enantioselectiveseparation of vigabatrin enantiomers by precolumn derivatization. J.Chromatogr. B, 2006, 833 : 186–190.

发明专利

1．王恒山; 潘英明; 黎霜. 从罗汉果残渣中提取多种成分，ZL 02133627.X，2004，中国专利授权

2．王恒山; 童碧海; 潘英明. 松香基吖啶类化合物的合成、其制造方法及其用途， ZL 200410040714.1，2006，中国专利授权

3．王恒山; 张业; 潘英明.  脱氢松香酸甲酯呋咱衍生物，其合成方法及其用途，申请号：200410081396.3，2004，中国专利

4. 王恒山, 戴伟龙, 潘英明, 姚贵阳, 程克光, 陈振锋, 田小艳. 茜素二氧杂环己烷衍生物及其制备方法和应用. 专利号: 201210324944.5.

5. 王恒山; 潘英明; 黄卫根; 谭恒; 刘志芳; 刘陆智. 脱氢松香基硫脲衍生物及其制备方法和应用 专利号:201010284217

6. 王恒山，黄日镇，潘英明，姚贵阳，戴伟龙，叶鳗仪，陈振锋. 大黄酸氨基膦酸酯衍生物及其合成方法和应用. 专利号:201310475681.2

7. 王恒山, 黄日镇, 潘英明, 姚贵阳, 戴伟龙, 叶鳗仪, 陈振锋. 双乙酰大黄酸氨基膦酸酯衍生物及其合成方法和应用. 专利号201310475685.0

8. 王恒山, 潘英明, 姚贵阳, 叶鳗仪, 黄日镇. 茜素氨基膦酸酯衍生物及其合成方法和应用. 专利号ZL201310730928.0

9. 王恒山，梁东，姚维娜，黄日镇，王春姑，潘英明，张斌，代禄梅。一种含吡喃环酚类化合物及其制备方法和应用，专利申请号201710053753.2

联系方式

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