陈振锋 教授

发布者: 华静 发布时间: 2018-11-23 浏览次数: 1822


陈振锋    博士;教授;博士生导师

  

Tel: +86-773-2120998

Fax: +86-773-2120958

E-mail: chenzf@gxnu.edu.cn

基本介绍

广西师范大学-省部共建药用资源化学与药物分子工程国家重点实验室常务副主任,教授,博士生导师,教育部创新团队负责人,教育部新世纪优秀人才支持计划人选,广西首批八桂学者,国家百千万人才工程人选,国家有突出贡献的中青年专家,国务案院政府特殊津贴专家。先后主持973计划前期研究专项课题1项,国家自然科学基金项目4项(面上项目2项),教育部创新团队发展计划项目2项(1项滚动支持),教育部重点项目2项,教育部新世纪优秀人才支持计划资助项目1项,广西自然科学基金创新团队项目1项,广西自然科学基金重点项目等4项。作为第二成员参与国家自然科学基金重点项目,国家自然科学基金与地区基金联合资助项目各1项,973计划前期研究专项各3项。主要开展中药活性成分金属药物化学化学研究,提出和实现了利用中药活性成分与金属活性中心配位调控效应设计金属药物的思想,获得系列具有多靶点、多重作用机制的金属抗肿瘤先导化合物。已在J. Med. Chem.Green Chem., Chem. Commun., Org. Lett., Eur. J. Med. Chem.Chem. Eur. J.Inorg. Chem. Dalton Trans.J. Inorg. Biochem., J. Biol. Inorg. Chem., Current Topics in Med. Chem., Anti-Cancer Agents in Medicinal Chemistry等国际、国内刊物正式发表SCI收录论文220余篇,获国家授权发明专利50余项。获广西科学技术特别贡献奖(排名2),广西科学技术进步奖一等奖(排名第2),以及广西自然科学奖二等奖(排名第4)和三等奖(排名第1)各一项,自治区级教学成果奖三等奖1项(排名第4),第八届广西青年科技奖。《广西师范大学学报》编委和J. Med. Chem.Eur. J. Med. Chem.Chem. Commun., Dalton Trans.Evidence Based Complementary and Alternative MedicineMini-Reviews in Medicinal ChemistryBioorg. & Med. Chem. Lett.Inorg. Chem.《中国科学》等近20种刊物的审稿人。是国家自然科学基金委员化学部和医学部通讯评审专家。

教育背景

1998.09-2001.06 南京大学,化学化工学院,博士

1995.09-1998.06 广西师范大学,化学化工学院,硕士

1989.09-1993.06 广西师范学院,化学系,学士

工作经历

2018.03-2018.06 广西社会主义学院党外中青年干部培训班学习,任组长

2017.12-今九三学社第十一次全国代表大会代表

2016.05-今中国科协九大全国代表大会代表

2016.01-今广西师范大学-省部共建药用资源化学与药物分子工程国家重点实验室常务副主任

2010.08-2015.12 国家重点实验室培育基地常务副主任

2006.01-2015.12 广西师范大学,教育部重点实验室常务副主任,化学化工学院副院长,中华青年联合会第十届委员会委员(2006-2010)

2006-2007 英属哥伦比亚大学Chris Orvig教授实验室访问教授

2005.01-今广西师范大学,广西重点实验室常务副主任

2004.03-2006.03 广西师范大学,化学化工学院,分工会主席

2003.12-2004.12 广西师范大学,广西高校重点实验室主任

2001.07-2003.11 广西师范大学化学与药学学院,无机化学教研室主任

荣誉及奖励

1)广西科学技术特别贡献奖(2017

2)国家重点实验室固定研究人员(2016

3)享受国务院政府特殊津贴人员(2016

4)广西自然科学奖二等奖(2016

5)国家人社部百千万人才工程入选者(2015

6)国家有突出贡献的中青年专家(2015

7)广西自然科学奖三等奖(2012

8)教育部创新团队负责人(2012

9)广西首批八桂学者(2011

10)第八届“广西青年科技奖”(2006

11)自治区级教学成果奖三等奖(2005

12)教育部新世纪优秀人才支持计划人选(2004

10)广西科技进步奖一等奖(2003

11)广西高校百名中青年学科带头人之一(2002

12)广西师范大学优秀青年教师(2001


Representative Publications

1. Ke-Bin Huang, Feng-Yang Wang, Xiao-Ming Tang, Hai-Wen Feng, Zhen-Feng Chen*, Yan-Cheng Liu, You-Nian Liu and Hong Liang*. Organometallic gold(III) complexes similar to tetrahydroisoquinoline(THIQ) induce ER-stress-mediated apoptosis and pro-death autophagyin A549 cancer cells. J. Med. Chem., 2018, 61, 3478-3490.

2. Zhen-FengChen,* Qi-Pin Qin, Jiao-Lan Qin, Yan-Cheng Liu, Ke-Bin Huang, Yu-Lan Li,Ting Meng, Guo-Hai Zhang,Yan Peng, Xu-Jian Luo, Hong Liang*. Stabilization of G-quadruplex DNA, inhibition of telomerase activity, and tumor cell apoptosis by organoplatinum(II) complexes with oxoisoaporphine. J. Med. Chem., 2015, 58, 2159-2179.

3. Zhen-Feng Chen,* Qi-Pin Qin, Jiao-Lan Qin, Jie Zhou, Yu-Lan Li, Nan Li, Yan-Cheng Liu, Hong Liang*. Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): invitro and in vivo anticancer activity by stabilization of G-quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis. J. Med. Chem., 2015, 58, 4771-4789.

4. Yan-Cheng Liu, Zhen-Feng Chen*, Xiao-Yan Song, Yan Peng, Qi-Pin Qin, Hong Liang*. Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dibromo-8-quinolinolato- lanthanides. Eur. J. Med. Chem., 2013, 59, 168-175.

5. Zhen-Feng Chen*, Yun-Qiong Gu, Xiao-Yan Song, Yan-Cheng Liu, Yan Peng, Hong Liang*. Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dichloro-8- quinolinolato-lanthanides. Eur. J. Med. Chem., 2013, 59, 194-202.

6. Zhen-Feng Chen*, Yan Peng, Yun-Qiong Gu, Yan-Cheng Liu, Mei Liu, Ke-Bin Huang, Kun Hu and Hong Liang*. High antitumor activity of 5,7-dihalo-8- quinolinolato tin(IV) complexes. Eur. J. Med. Chem., 2013, 62,51-58.

7. Ke-Bin Huang, Zhen-Feng Chen*, Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang Guo-Hai Zhang, Hong Liang*. Platinum(II) complexes with mono-aminopho- sphonate ester targeting group that induce apoptosis through G1 cell-cycle arrest: Synthesis, crystal structure and antitumour activity. Eur. J. Med. Chem., 2013, 63, 76-84.

8. Ke-Bin Huang, Zhen-Feng Chen,* Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang, Xiao-Li Xie, and Hong Liang*. Platinum(II) complexes containing aminophosphonate esters: synthsis, characterization, cytotoxicity and action mechanism. Eur. J. Med. Chem., 2013, 64, 554-561.

9. Zhen-Feng Chen,* Jian-Hua Wei, Yan-Cheng Liu, Mei Liu, Yun-Qiong Gu, Ke-Bin Huang, Meng Wang, Hong Liang*. High antitumor activity of 5,7-dihalo-8-quinolinolato cerium complexes. Eur. J. Med. Chem., 2013, 68, 454-462.

10. Yan-Cheng Liu, Jian-Hua Wei, Zhen-Feng Chen*, Mei Liu, Yun-Qiong Gu, Ke-Bin Huang, Zhu-Quan Li and Hong Liang*. The antitumor activity of zinc(II) and copper(II) complexes with 5,7-dihalo-substituted-8-quinolinoline. Eur. J. Med. Chem., 2013, 69,554-563.

11. Ke-Bin Huang, Zhen-Feng Chen*, Yan-Cheng Liu, Meng Wang, Jian-Hua Wei, Xiao-Li Xie, Jian-Lian Zhang, Kun Hu, Hong Liang*. Copper(II/I) complexes of 5-pyridin-2-yl-[1,3] dioxolo[4,5-g]isoquinoline: synthesis, crystal structure, antitumor activity and DNA interaction. Eur. J. Med. Chem., 2013, 70, 640-648.

12. Qi-Pin Qin, Zhen-Feng Chen*, Wen-Ying Shen, Yan-Hua Jiang, Dong Cao, Yu-Lan Li, Qing-Min Xu, Yan-Cheng Liu, Ke-Bin Huang, Hong Liang*. Synthesis of a platinum(II) complex with 2-(4-methoxy-phenyl)imidazo [4,5-f]-[1,10] phenanthrolin and study of its antitumor activity. Eur. J. Med. Chem., 2015, 89, 77-87.

13. Qi-Pin Qin, Zhen-Feng Chen*, Jiao-Lan Qin, Xiao-Ju He, Yu-Lan Li, Yan-Cheng Liu, Ke-Bin Huang and Hong Liang*. Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: synthesis, characterization, cytotoxicity, cell cycle and apoptosis. Eur. J. Med. Chem., 2015, 92, 302-313.

14. Qi-Pin Qin, Jiao-Lan Qin, Ting Meng, Wan-Hua Lin, Chuan-Hui Zhang, Zu-Zhuang Wei, Jia-Nian Chen, Yan-Cheng Liu, Hong Liang, Zhen-Feng Chen*. High in vivo antitumor activity of cobalt oxoisoaporphine complexes by targeting G-quadruplex DNA, telomerase and disrupting mitochondrial functions. Eur. J. Med. Chem., 2016, 124, 380−392.

15. Yan-Cheng Liu, Jian-Hua Wei, Zhen-Feng Chen*, Mei Liu, Yun-Qiong Gu, Ke-Bin Huang, Zhu-Quan Li and Hong Liang*. The antitumor activity of zinc(II) and copper(II) complexes with 5,7-dihalo-substituted-8-quinolinoline. Eur. J. Med. Chem., 2013, 69,554-563.

16. Zu-Zhuang Wei(#), Qi-Pin Qin(#), Ting Meng, Cai-Xing Deng, Hong Liang, Zhen-Feng Chen*. 5-Bromo-oxoisoaporphine platinum(II) complexes exhibit tumor cell cytotoxcicity via inhibition of telomerase activity and disruption of c-myc G-quadruplex DNA and mitochondrial functions. Eur. J. Med. Chem., 2018, 145, 360-369.

17. Wen-Bin Kuang, Ri-Zhen Huang, Jiao-Lan Qin, Xing Lu, Qi-Pin Qin, Bi-Qun Zou, Zhen-Feng Chen,**, Hong Liang,***, Ye Zhang*. Design, synthesis and pharmacological evaluation of new 3-(1Hbenzimidazol-2-yl)quinolin-2(1H)-one derivatives as potential antitumor agents. Eur. J. Med. Chem., 2018, 157, 139-150.

18. Taj-Malook Khan, Noor Shad Gul, Xing Lu, Jian-Hua Wei, Yan-Cheng Liu, Hongbin Sun*, Hong Liang***, Chris Orvig, Zhen-Feng Chen**. In vitro and in vivo anti-tumor activity of two gold(III) complexes with isoquinoline derivatives as ligands. Eur. J. Med. Chem., 2019, 163, 333-342.

19. Bao-Li Fei*, Shuangyan Tu, Zuzhuang Wei, Pingping Wang, Chunhua Qiao ***, Zhen-Feng Chen**. Optically pure chiral copper(II) complexes of rosin derivative as attractive anticancer agents with potential anti-metastatic and anti-angiogenic activities. Eur. J. Med. Chem., 2019, 176, 175-186.

20. Xing Lu, Yan-Cheng Liu, Chris Orvig, Hong Liang **, Zhen-Feng Chen*. Discovery of b-carboline copper(II) complexes as Mcl-1 inhibitor and in vitro and in vivo activity in cancer models. Eur. J. Med. Chem., 2019, 181, 111567.

21. Zhen-Feng Chen*, Chris Orvig and Hong Liang*. Multi-target metal-based anticancer agents. Current Topics in Medicinal Chemistry, 2017,17, 1331-1345.

22. Zhen-Feng Chen*, Yan-Cheng Liu, Ke-Bin Huang and Hong Liang*. Alkaloid-metal based anticancer agents. Current Topics in Medicinal Chemistry, 2013, 13, 2104-2115.

23. Zhen-Feng Chen*, Yan-Fang Shi, Yan-Cheng Liu, Xue Hong, Bo Geng, Yan Peng, Hong Liang*, TCM active ingredient oxoglaucine metal complexes: Crystal structure, cytotoxicity and interaction with DNA. Inorganic Chemistry, 2012, 51, 1998-2009.

24. Bao-Li Fei*, Shuangyan Tu, Zuzhuang Wei, Pingping Wang, Jian-Ying Long, Chunhua Qiao* and Zhen-Feng Chen*. Biological evaluation of optically pure chiral binuclear copper(II) complexes based on rosin derivative as highly potential anticancer agents. Dalton Trans., 2019, DOI: 10.1039/C9DT01942A.

25. Taj-Malook Khan, Noor Shad Gul, Xing Lu, Rajesh Kumar, Muhammad Iqbal Choudhary,b Hong Liang* and Zhen-Feng Chen*. Rhodium(III) complexes with isoquinoline derivatives as potential anticancer agents: in vitro and in vivo activity studies. Dalton Trans., 2019, 48,11469-11479.

26. Qi-Pin Qin, Jiao-Lan Qin, Ming Chen, Yu-Lan Li, Ting Meng, Jie Zhou, Hong Liang*, Zhen-Feng Chen*. Chiral platinum(II)-4-(2,3-Dihydroxypropyl)- formamide oxoaporphine (FOA) complexes promote tumor cells apoptosis by directly targeting G-quadruplex DNA in vitro and in vivo. Oncotarget, 2017, 8, 61982-61997.

27. Jiao-Lan Qin, Ting Meng, Zhen-Feng Chen*, Xiao-Li Xie, Qi-Pin Qin, Xiao-Ju He, Ke-Bin Huang, Hong Liang*. Facile total synthesis of lysicamine and the anticancer activities of the RuII, RhIII, MnII and ZnII complexes of lysicamine. Oncotarget, 2017, 8, 59359-59375.

28. Jiao-Lan Qin(#), Wen-Ying Shen(#), Zhen-Feng Chen*, Li-Fang Zhao, Qi-Pin Qin, Yan-Cheng Yu & Hong Liang*. Oxoaporphine metal complexes (CoII, NiII, ZnII) with high antitumor activity by inducing mitochondria-mediated apoptosis and S-phase arrest in HepG2. Scientific Reports, 2017, 7:46056.

29. Qi-Pin Qin(#), Jiao-Lan Qin(#), Ting Meng, Gui-Ai Yang, Zu-Zhuang Wei, Yan-Cheng Liu, Hong Liang* & Zhen-Feng Chen*. Preparation of 6/8/11-amino/chloro-oxoisoaporphine and group-10 metal complexes and evaluation of their in vitro and in vivo antitumor activity. Scientific Reports, 2016, 6: 37644.

30. Guohai Zhang, Yunfeng An, Xing Lu, Hui Zhong, Yanhong Zhu, Yiming Wu, Feng’e, Ma, Jingmei Yang, Yancheng Liu, Zuping Zhou, Yan Peng*, Zhenfeng Chen*. A novel naphthalimide compound restores p53 function in non–small–cell lung cancer by reorganizing the Bak–Bcl-xl complex and triggering transcriptional regulation. J. Biol. Chem., 2016, 291, 4211-4225.

31. Guo-Hai Zhang#, Le-Jing Cai#, Yan-Fei Wang, Yuan-Hua Zhou, Yun-Feng An, Yan-Cheng Liu, Yan Peng*, Zhen-Feng Chen*, Hong Liang*. Novel compound PS-101 exhibits selective inhibition in non–small-cell lung cancer cell by blocking the EGFR-driven antiapoptotic pathway. Biochemical Pharmacology, 2013, 86, 1721-1730.

32. Zu-Yu Mo, Toreshettahally R. Swaroop, Wei Tong, Yu-Zhen Zhang,Hai-Tao Tang,* Ying-Ming Pan,* Hong-Bin Sun and Zhen-Feng Chen*. Electrochemical sulfonylation of thiols with sulfonyl hydrazides: a metal- and oxidant-free protocol for the synthesis of thiosulfonates. Green Chemistry, 2018, 20(19), 4428-4432.32.

33. Pei Liu, Jin-ling Liu, Heng-shan Wang,Ying-ming Pan*, Hong Liang, and Zhen-Feng Chen*. Copper-mediated crossing-coupling/cyclization/oxidation: One-pot to construct polysubstitutedpyrroles. Chem. Commun. 2014, 50, 4795-4798.

34. Pei Liu, Heng-shan Wang, Ying-ming Pan,* Wei-long Dai, Hong Liang and Zhen-Feng Chen*. The first palladium-catalyzed 1,4-addition of terminal alkenes to acrylate esters. Chem. Commoun., 2013, 49, 5295-5297.

35. Xu Wang, Shen-yan Li, Ying-ming Pan*, Heng-shan Wang, Hong Liang, Zhen-Feng Chen*, and Xiao-huan Qin. Samarium(III)-catalyzed C(sp3)–H bond activation: Synthesis of indolizines via C–C and C–N coupling between 2-alkylazaarenes and propargylic alcohols. Org. Lett., 2014, 16, 580-583.